A1T5Z3 (AROA_MYCVP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	Mvan_1771

Organism

Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [Complete proteome] [HAMAP]

Taxonomic identifier

350058 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000099729

Sequences

	Sequence		Length	Mass (Da)
	A1T5Z3 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: F8AA5380D085C48B	FASTA	446	45,498
	10 20 30 40 50 60 MSTWPAPSTA TPVHATVTVP GSKSQTNRAL VLAALAVPQG SSTISGALRS RDTDLMISAL 70 80 90 100 110 120 QGLGVVVEAP DTDGSDGTEL TVSGALAPKA GARIDCGLAG TVLRFVPPVA ALTTETVTFD 130 140 150 160 170 180 GDEQARARPI APLLDGLRAL GVAIDGDGLP FSVRGQGSVR GGTVEIDASG SSQFVSGLLL 190 200 210 220 230 240 SGAAFTEGLT VVHTGGAVPS APHIAMTVSM LRDAGVEVDD SAADRWRVAP GPIAARHWAV 250 260 270 280 290 300 EPDLSNAVPF LAAAVISGGT VRVTGWPTVS TQPAATILSL LTSLGSEVRQ GNSHLEVQGA 310 320 330 340 350 360 TSYDGIDVDL RDVGELAPSV AAMAALASPG SVSRLRGIAH LRGHETDRLA ALSAELNRLG 370 380 390 400 410 420 GQCEETDDGL VITARQMHGG VWRSYADHRM ATAGAIVGLR VPGVEVEDIG TTAKTLPDFP 430 440 QLWADMLAGQ TDLQAGAPHA GRNQGR

References

[1]

"Complete sequence of Mycobacterium vanbaalenii PYR-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 7251 / PYR-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000511 Genomic DNA. Translation: ABM12593.1.
RefSeq	YP_952599.1. NC_008726.1.
3D structure databases
ProteinModelPortal	A1T5Z3.
SMR	A1T5Z3. Positions 1-428.
ModBase	Search...
Protein-protein interaction databases
STRING	A1T5Z3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000079456; EBMYCP00000077409; EBMYCG00000079451.
GeneID	4647067.
GenomeReviews	Gene locus Mvan_1771 in contig CP000511_GR.
KEGG	mva:Mvan_1771.
PATRIC	18181775. VBIMycVan31953_1817.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0128.
GeneTree	EBGT00050000016231.
HOGENOM	HBG646626.
OMA	HRMATAG.
PhylomeDB	A1T5Z3.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	MVAN350058:MVAN_1771-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_MYCVP

Accession

Primary (citable) accession number: A1T5Z3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program