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Protein

Adenosine deaminase

Gene

add

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Adenosine + H2O = inosine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19Zinc; catalyticUniRule annotation1
Metal bindingi21Zinc; catalyticUniRule annotation1
Binding sitei21SubstrateUniRule annotation1
Binding sitei23SubstrateUniRule annotation1
Binding sitei181Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi208Zinc; catalyticUniRule annotation1
Active sitei211Proton donorUniRule annotation1
Sitei232Important for catalytic activityUniRule annotation1
Metal bindingi300Zinc; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine deaminaseUniRule annotation (EC:3.5.4.4UniRule annotation)
Alternative name(s):
Adenosine aminohydrolaseUniRule annotation
Gene namesi
Name:addUniRule annotation
Ordered Locus Names:Mvan_1592
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000009159 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000176751 – 362Adenosine deaminaseAdd BLAST362

Interactioni

Protein-protein interaction databases

STRINGi350058.Mvan_1592.

Structurei

3D structure databases

ProteinModelPortaliA1T5H1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EKD. Bacteria.
COG1816. LUCA.
HOGENOMiHOG000218816.
KOiK01488.
OMAiDWMVAVL.
OrthoDBiPOG091H02QG.

Family and domain databases

HAMAPiMF_00540. A_deaminase. 1 hit.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028893. A_deaminase.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

A1T5H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTPLTFDNI RRAPKALLHD HLDGGLRPST VLELAEQYGY EDLPAHDADG
60 70 80 90 100
LATFFRTAAH SGSLVRYLEP FAHTVGVMQN PDALHRVARE CVEDLAADNV
110 120 130 140 150
VYAEVRFAPE LHIDGGLSLD AVVDAVLAGF ADGEKAAAAD GRAITVRCLV
160 170 180 190 200
TAMRHAARSR EIAELAIRFR DKGVVGFDIA GAEAGYPPSR HLDAFEYMRS
210 220 230 240 250
NNARFTIHAG EAFGLPSIHE AIAFCGADRL GHGVRIVDDI EIDADGNAKL
260 270 280 290 300
GRLASLLRDK RIPFEMCPSS NVQTGAVASI AEHPFDRLAR LRFRVTVNTD
310 320 330 340 350
NRLMSDTSMS MEMLRLVEAF GYGWSDLERF TINAMKSAFI AFDERLAIID
360
EVIKPRYAVL VG
Length:362
Mass (Da):39,652
Last modified:February 6, 2007 - v1
Checksum:i2DF0562058B4324B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM12421.1.
RefSeqiWP_011778846.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM12421; ABM12421; Mvan_1592.
KEGGimva:Mvan_1592.
PATRICi18181409. VBIMycVan31953_1634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM12421.1.
RefSeqiWP_011778846.1. NC_008726.1.

3D structure databases

ProteinModelPortaliA1T5H1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi350058.Mvan_1592.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM12421; ABM12421; Mvan_1592.
KEGGimva:Mvan_1592.
PATRICi18181409. VBIMycVan31953_1634.

Phylogenomic databases

eggNOGiENOG4105EKD. Bacteria.
COG1816. LUCA.
HOGENOMiHOG000218816.
KOiK01488.
OMAiDWMVAVL.
OrthoDBiPOG091H02QG.

Family and domain databases

HAMAPiMF_00540. A_deaminase. 1 hit.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028893. A_deaminase.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADD_MYCVP
AccessioniPrimary (citable) accession number: A1T5H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.