A1T5B1 (A1T5B1_MYCVP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Error-prone DNA polymerase HAMAP MF_01902
EC=2.7.7.7 HAMAP MF_01902

Gene names

Name:	dnaE2 HAMAP MF_01902
Ordered Locus Names:	Mvan_1530

Organism

Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [Complete proteome] [HAMAP]

Taxonomic identifier

350058 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	1098 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity. HAMAP MF_01902
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902 SAAS SAAS004013
Subcellular location	Cytoplasm By similarity HAMAP MF_01902 SAAS SAAS004013.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily. HAMAP MF_01902

Ontologies

Keywords
Biological process	DNA damage DNA repair HAMAP MF_01902 SAAS SAAS004013 DNA replication HAMAP MF_01902 SAAS SAAS004013
Cellular component	Cytoplasm HAMAP MF_01902 SAAS SAAS004013
Molecular function	DNA-directed DNA polymerase HAMAP MF_01902 SAAS SAAS004013 Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: HAMAP DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1T5B1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 963ACA50E9E4AED5	FASTA	1,098	119,006
	10 20 30 40 50 60 MGWHTGPPSW TEMERVLSGK PRRAGWPIDQ QIGDGGDSPA WSRKRGEYHA PEGPGAQESS 70 80 90 100 110 120 TPYAELHAHS AYSFLDGAST PEELVEEAAR LNLRAIALTD HDGLYGVVRF AEAARELDVA 130 140 150 160 170 180 TVFGAELSLG GGTRTDVPDP PGPHLLVLAR GPEGYRRLSR QLAAAHLAGG EKGVLRYDFD 190 200 210 220 230 240 ALTEAAGGHW QILTGCRKGH VRQALSTGGP EAAEAALADL VDRFGPDRVT VELTHHGHPL 250 260 270 280 290 300 DDERNAALAA LAPRFGLGVV ATTAAHFAEP ARGRLAMAMG AIRARNSIDE AAGYLAPLGG 310 320 330 340 350 360 SHLRSGDEMA RMFAHCPEVV TAAAELGEQC AFGLALIAPQ LPPFDVPDGH TESSWLRHLV 370 380 390 400 410 420 MQGARERYGP PERASRAYAQ IEHELAVIEQ LNFPGYFLVV HDITRFCRDN NILSQGRGSA 430 440 450 460 470 480 ANSAVCYALK VTNVDPIAND LLFERFLSPA RDGPPDIDID IESDLRENAI QYVYQRYGRE 490 500 510 520 530 540 YAAQVANVIT YRGRSAVRDM ARALGFSQGQ QDAWSKQVSQ WGNLADATHV EDIPGPVVDL 550 560 570 580 590 600 AKQISNLPRH MGIHSGGMVI CDRPIADVCP VEWARMENRS VLQWDKDDCA AIGLVKFDLL 610 620 630 640 650 660 GLGMLSALHY AIDLVAEHKG IEVDLAKLDL SEPAVYEMLA RADSVGVFQV ESRAQMATLP 670 680 690 700 710 720 RLKPRMFYDL VVEVALIRPG PIQGGSVHPY IKRRNGQEAV TYDHPSMESA LRKTLGVPLF 730 740 750 760 770 780 QEQLMQLAVD CAGFTPAEAD QLRRAMGSKR STEKMRRLRG RFFDGMAELH GVTGDVAQRI 790 800 810 820 830 840 YEKLEAFANF GFPESHSLSF ASLVFYSSWF KLHHPAAFCA ALLRAQPMGF YSPQSLVADA 850 860 870 880 890 900 RRHGVVVHGP DVNAGLAHAT LENHGLDVRL GLGGVRHIGD ELAERLVGER KAHGPFTSLT 910 920 930 940 950 960 DLTRRVQLSV PQTEALATAG ALGCFGITRR EGLWAAGAAA TERPDRLPGV GSSSHVPSLP 970 980 990 1000 1010 1020 GMTELELTVA DVWATGVSPD RYPTEFLRED LDAMGVVPAD QLLSLPDGTR VLVAGAVTHR 1030 1040 1050 1060 1070 1080 QRPATAQGVT FMNLEDETGM VNVLCSQGVW ARHRKLAQTA SALVVRGIVQ NATGAVTVVA 1090 DRMGRLSLRA ASKSRDFR

References

[1]

"Complete sequence of Mycobacterium vanbaalenii PYR-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 7251 / PYR-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000511 Genomic DNA. Translation: ABM12361.1.
RefSeq	YP_952367.1. NC_008726.1.
3D structure databases
ProteinModelPortal	A1T5B1.
ModBase	Search...
Protein-protein interaction databases
STRING	A1T5B1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000083317; EBMYCP00000081270; EBMYCG00000083312.
GeneID	4648263.
GenomeReviews	Gene locus Mvan_1530 in contig CP000511_GR.
KEGG	mva:Mvan_1530.
PATRIC	18181281. VBIMycVan31953_1570.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0587.
GeneTree	EBGT00050000016568.
HOGENOM	HBG734490.
OMA	EQPAIRL.
ProtClustDB	PRK05672.
Family and domain databases
HAMAP	MF_01902. DNApol_error_prone. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR023073. DNA_pol_error_prone. IPR012340. NA-bd_OB-fold. IPR004365. NA-bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KO	K14162.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A1T5B1_MYCVP

Accession

Primary (citable) accession number: A1T5B1

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)