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Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei261D-inositol 3-phosphateUniRule annotation1
Binding sitei40UDP-GlcNAc; via amide nitrogenUniRule annotation1
Binding sitei951D-inositol 3-phosphateUniRule annotation1
Binding sitei1281D-inositol 3-phosphateUniRule annotation1
Binding sitei1521D-inositol 3-phosphateUniRule annotation1
Binding sitei1721D-inositol 3-phosphateUniRule annotation1
Binding sitei246UDP-GlcNAcUniRule annotation1
Binding sitei251UDP-GlcNAcUniRule annotation1
Binding sitei313UDP-GlcNAc; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi322Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi323Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi325Magnesium; via carbonyl oxygenUniRule annotation1
Binding sitei335UDP-GlcNAcUniRule annotation1
Binding sitei343UDP-GlcNAcUniRule annotation1
Metal bindingi349MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciMVAN350058:G1G7S-834-MONOMER

Protein family/group databases

CAZyiGT4 Glycosyltransferase Family 4

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:Mvan_0827
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000009159 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004001451 – 450D-inositol 3-phosphate glycosyltransferaseAdd BLAST450

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi350058.Mvan_0827

Structurei

3D structure databases

ProteinModelPortaliA1T3B5
SMRiA1T3B5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni32 – 33UDP-GlcNAc bindingUniRule annotation2
Regioni37 – 421D-inositol 3-phosphate bindingUniRule annotation6

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M Bacteria
COG0438 LUCA
HOGENOMiHOG000077288
KOiK15521
OMAiHTMAKVK
OrthoDBiPOG091H0AO3

Family and domain databases

HAMAPiMF_01695 MshA, 1 hit
InterProiView protein in InterPro
IPR001296 Glyco_trans_1
IPR028098 Glyco_trans_4-like_N
IPR017814 Mycothiol_biosynthesis_MshA
PfamiView protein in Pfam
PF13439 Glyco_transf_4, 1 hit
PF00534 Glycos_transf_1, 1 hit
TIGRFAMsiTIGR03449 mycothiol_MshA, 1 hit

Sequencei

Sequence statusi: Complete.

A1T3B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLATEPASL PSGLPEPRRV AVLSVHTSPL AQPGTGDAGG MNVYVLQTAL
60 70 80 90 100
ELANRGVDVE IFTRATSSAD QPVVPVAPGV LVRNVVAGPF EGLDKNDLPT
110 120 130 140 150
QLCAFTAGVL RAEATHEPGY YDIVHSHYWL SGQVGWLAAD RWAVPLVHTA
160 170 180 190 200
HTLAAVKNAS LAAGDAPEPP MRSIGEQQVV DAADRLIVNT EHEAQQLVSL
210 220 230 240 250
HQADPARIDV VHPGVDLATF TPGDRLAARA ALGLDANSRI VAFVGRIQPL
260 270 280 290 300
KAPDVLLRAA ALLPDVQVLI AGGPSGSGLI SRPGAGGLAT PDNLVNLAAE
310 320 330 340 350
LGMTDRVTFL PPQSRDNLVQ VYRAADVVAV PSYSESFGLV AVEAQACGTP
360 370 380 390 400
VVAAAVGGLP VAVRDGVSGA LVDGHDPGDW AGTLADVLAA DPATLSRAAV
410 420 430 440 450
DHAATFSWSH TVDALLAGYG RAIADHRARH QGQLARRSGR RFSMRRGVRA
Length:450
Mass (Da):46,802
Last modified:February 6, 2007 - v1
Checksum:i22BB995E57C26DA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA Translation: ABM11665.1
RefSeqiWP_011778101.1, NC_008726.1

Genome annotation databases

EnsemblBacteriaiABM11665; ABM11665; Mvan_0827
KEGGimva:Mvan_0827

Similar proteinsi

Entry informationi

Entry nameiMSHA_MYCVP
AccessioniPrimary (citable) accession number: A1T3B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: February 6, 2007
Last modified: February 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome