UniProtKB - A1T3B5 (MSHA_MYCVP)
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Protein
D-inositol 3-phosphate glycosyltransferase
Gene
mshA
Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Functioni
Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation
Catalytic activityi
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 26 | 1D-inositol 3-phosphateUniRule annotation | 1 | |
Binding sitei | 40 | UDP-GlcNAc; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 95 | 1D-inositol 3-phosphateUniRule annotation | 1 | |
Binding sitei | 128 | 1D-inositol 3-phosphateUniRule annotation | 1 | |
Binding sitei | 152 | 1D-inositol 3-phosphateUniRule annotation | 1 | |
Binding sitei | 172 | 1D-inositol 3-phosphateUniRule annotation | 1 | |
Binding sitei | 246 | UDP-GlcNAcUniRule annotation | 1 | |
Binding sitei | 251 | UDP-GlcNAcUniRule annotation | 1 | |
Binding sitei | 313 | UDP-GlcNAc; via amide nitrogen and carbonyl oxygenUniRule annotation | 1 | |
Metal bindingi | 322 | Magnesium; via carbonyl oxygenUniRule annotation | 1 | |
Metal bindingi | 323 | Magnesium; via carbonyl oxygenUniRule annotation | 1 | |
Metal bindingi | 325 | Magnesium; via carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 335 | UDP-GlcNAcUniRule annotation | 1 | |
Binding sitei | 343 | UDP-GlcNAcUniRule annotation | 1 | |
Metal bindingi | 349 | MagnesiumUniRule annotation | 1 |
GO - Molecular functioni
- acetylglucosaminyltransferase activity Source: InterPro
- D-inositol-3-phosphate glycosyltransferase activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- mycothiol biosynthetic process Source: InterPro
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BioCyci | MVAN350058:G1G7S-834-MONOMER |
Protein family/group databases
CAZyi | GT4 Glycosyltransferase Family 4 |
Names & Taxonomyi
Protein namesi | Recommended name: D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)Alternative name(s): N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation Short name: GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation |
Gene namesi | Name:mshAUniRule annotation Ordered Locus Names:Mvan_0827 |
Organismi | Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1) |
Taxonomic identifieri | 350058 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000400145 | 1 – 450 | D-inositol 3-phosphate glycosyltransferaseAdd BLAST | 450 |
Interactioni
Subunit structurei
Homodimer.UniRule annotation
Protein-protein interaction databases
STRINGi | 350058.Mvan_0827 |
Structurei
3D structure databases
ProteinModelPortali | A1T3B5 |
SMRi | A1T3B5 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 32 – 33 | UDP-GlcNAc bindingUniRule annotation | 2 | |
Regioni | 37 – 42 | 1D-inositol 3-phosphate bindingUniRule annotation | 6 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG4107R5M Bacteria COG0438 LUCA |
HOGENOMi | HOG000077288 |
KOi | K15521 |
OMAi | HTMAKVK |
OrthoDBi | POG091H0AO3 |
Family and domain databases
HAMAPi | MF_01695 MshA, 1 hit |
InterProi | View protein in InterPro IPR001296 Glyco_trans_1 IPR028098 Glyco_trans_4-like_N IPR017814 Mycothiol_biosynthesis_MshA |
Pfami | View protein in Pfam PF13439 Glyco_transf_4, 1 hit PF00534 Glycos_transf_1, 1 hit |
TIGRFAMsi | TIGR03449 mycothiol_MshA, 1 hit |
i Sequence
Sequence statusi: Complete.
A1T3B5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLATEPASL PSGLPEPRRV AVLSVHTSPL AQPGTGDAGG MNVYVLQTAL
60 70 80 90 100
ELANRGVDVE IFTRATSSAD QPVVPVAPGV LVRNVVAGPF EGLDKNDLPT
110 120 130 140 150
QLCAFTAGVL RAEATHEPGY YDIVHSHYWL SGQVGWLAAD RWAVPLVHTA
160 170 180 190 200
HTLAAVKNAS LAAGDAPEPP MRSIGEQQVV DAADRLIVNT EHEAQQLVSL
210 220 230 240 250
HQADPARIDV VHPGVDLATF TPGDRLAARA ALGLDANSRI VAFVGRIQPL
260 270 280 290 300
KAPDVLLRAA ALLPDVQVLI AGGPSGSGLI SRPGAGGLAT PDNLVNLAAE
310 320 330 340 350
LGMTDRVTFL PPQSRDNLVQ VYRAADVVAV PSYSESFGLV AVEAQACGTP
360 370 380 390 400
VVAAAVGGLP VAVRDGVSGA LVDGHDPGDW AGTLADVLAA DPATLSRAAV
410 420 430 440 450
DHAATFSWSH TVDALLAGYG RAIADHRARH QGQLARRSGR RFSMRRGVRA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000511 Genomic DNA Translation: ABM11665.1 |
RefSeqi | WP_011778101.1, NC_008726.1 |
Genome annotation databases
EnsemblBacteriai | ABM11665; ABM11665; Mvan_0827 |
KEGGi | mva:Mvan_0827 |
Similar proteinsi
Entry informationi
Entry namei | MSHA_MYCVP | |
Accessioni | A1T3B5Primary (citable) accession number: A1T3B5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 2, 2010 |
Last sequence update: | February 6, 2007 | |
Last modified: | February 28, 2018 | |
This is version 67 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |