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Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei26 – 2611D-inositol 3-phosphateUniRule annotation
Binding sitei40 – 401UDP-GlcNAc; via amide nitrogenUniRule annotation
Binding sitei95 – 9511D-inositol 3-phosphateUniRule annotation
Binding sitei128 – 12811D-inositol 3-phosphateUniRule annotation
Binding sitei152 – 15211D-inositol 3-phosphateUniRule annotation
Binding sitei172 – 17211D-inositol 3-phosphateUniRule annotation
Binding sitei246 – 2461UDP-GlcNAcUniRule annotation
Binding sitei251 – 2511UDP-GlcNAcUniRule annotation
Binding sitei313 – 3131UDP-GlcNAc; via amide nitrogen and carbonyl oxygenUniRule annotation
Metal bindingi322 – 3221Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi323 – 3231Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi325 – 3251Magnesium; via carbonyl oxygenUniRule annotation
Binding sitei335 – 3351UDP-GlcNAcUniRule annotation
Binding sitei343 – 3431UDP-GlcNAcUniRule annotation
Metal bindingi349 – 3491MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-832-MONOMER.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:Mvan_0827
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000009159 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450D-inositol 3-phosphate glycosyltransferasePRO_0000400145Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi350058.Mvan_0827.

Structurei

3D structure databases

ProteinModelPortaliA1T3B5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni32 – 332UDP-GlcNAc bindingUniRule annotation
Regioni37 – 4261D-inositol 3-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.

Sequencei

Sequence statusi: Complete.

A1T3B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLATEPASL PSGLPEPRRV AVLSVHTSPL AQPGTGDAGG MNVYVLQTAL
60 70 80 90 100
ELANRGVDVE IFTRATSSAD QPVVPVAPGV LVRNVVAGPF EGLDKNDLPT
110 120 130 140 150
QLCAFTAGVL RAEATHEPGY YDIVHSHYWL SGQVGWLAAD RWAVPLVHTA
160 170 180 190 200
HTLAAVKNAS LAAGDAPEPP MRSIGEQQVV DAADRLIVNT EHEAQQLVSL
210 220 230 240 250
HQADPARIDV VHPGVDLATF TPGDRLAARA ALGLDANSRI VAFVGRIQPL
260 270 280 290 300
KAPDVLLRAA ALLPDVQVLI AGGPSGSGLI SRPGAGGLAT PDNLVNLAAE
310 320 330 340 350
LGMTDRVTFL PPQSRDNLVQ VYRAADVVAV PSYSESFGLV AVEAQACGTP
360 370 380 390 400
VVAAAVGGLP VAVRDGVSGA LVDGHDPGDW AGTLADVLAA DPATLSRAAV
410 420 430 440 450
DHAATFSWSH TVDALLAGYG RAIADHRARH QGQLARRSGR RFSMRRGVRA
Length:450
Mass (Da):46,802
Last modified:February 6, 2007 - v1
Checksum:i22BB995E57C26DA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM11665.1.
RefSeqiWP_011778101.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM11665; ABM11665; Mvan_0827.
KEGGimva:Mvan_0827.
PATRICi18179835. VBIMycVan31953_0851.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM11665.1.
RefSeqiWP_011778101.1. NC_008726.1.

3D structure databases

ProteinModelPortaliA1T3B5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi350058.Mvan_0827.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM11665; ABM11665; Mvan_0827.
KEGGimva:Mvan_0827.
PATRICi18179835. VBIMycVan31953_0851.

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-832-MONOMER.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSHA_MYCVP
AccessioniPrimary (citable) accession number: A1T3B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: February 6, 2007
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.