mshA

Functionⁱ

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityⁱ

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	26	1D-inositol 3-phosphateUniRule annotation	1
Binding siteⁱ	40	UDP-GlcNAc; via amide nitrogenUniRule annotation	1
Binding siteⁱ	95	1D-inositol 3-phosphateUniRule annotation	1
Binding siteⁱ	128	1D-inositol 3-phosphateUniRule annotation	1
Binding siteⁱ	152	1D-inositol 3-phosphateUniRule annotation	1
Binding siteⁱ	172	1D-inositol 3-phosphateUniRule annotation	1
Binding siteⁱ	246	UDP-GlcNAcUniRule annotation	1
Binding siteⁱ	251	UDP-GlcNAcUniRule annotation	1
Binding siteⁱ	313	UDP-GlcNAc; via amide nitrogen and carbonyl oxygenUniRule annotation	1
Metal bindingⁱ	322	Magnesium; via carbonyl oxygenUniRule annotation	1
Metal bindingⁱ	323	Magnesium; via carbonyl oxygenUniRule annotation	1
Metal bindingⁱ	325	Magnesium; via carbonyl oxygenUniRule annotation	1
Binding siteⁱ	335	UDP-GlcNAcUniRule annotation	1
Binding siteⁱ	343	UDP-GlcNAcUniRule annotation	1
Metal bindingⁱ	349	MagnesiumUniRule annotation	1

GO - Molecular functionⁱ

acetylglucosaminyltransferase activity Source: InterPro
D-inositol-3-phosphate glycosyltransferase activity Source: UniProtKB-EC
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mycothiol biosynthetic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosyltransferase, Transferase
Ligand	Magnesium, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MVAN350058:G1G7S-834-MONOMER

BioCycⁱ

MVAN350058:G1G7S-834-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT4 Glycosyltransferase Family 4

CAZyⁱ

GT4 Glycosyltransferase Family 4

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation) Alternative name(s): N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation Short name: GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesⁱ	Name:mshAUniRule annotation Ordered Locus Names:Mvan_0827
Organismⁱ	Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifierⁱ	350058 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Actinobacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium vanbaalenii
Proteomesⁱ	UP000009159 Componentⁱ: Chromosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000400145	1 – 450	D-inositol 3-phosphate glycosyltransferaseAdd BLAST		450

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	350058.Mvan_0827

STRINGⁱ

350058.Mvan_0827

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A1T3B5
SMRⁱ	A1T3B5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	32 – 33	UDP-GlcNAc bindingUniRule annotation		2
Regionⁱ	37 – 42	1D-inositol 3-phosphate bindingUniRule annotation		6

Sequence similaritiesⁱ

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4107R5M Bacteria COG0438 LUCA
HOGENOMⁱ	HOG000077288
KEGG Orthology (KO) More...KOⁱ	K15521
OMAⁱ	HTMAKVK
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0AO3

Family and domain databases

HAMAPⁱ	MF_01695 MshA, 1 hit
InterProⁱ	View protein in InterPro IPR001296 Glyco_trans_1 IPR028098 Glyco_trans_4-like_N IPR017814 Mycothiol_biosynthesis_MshA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13439 Glyco_transf_4, 1 hit PF00534 Glycos_transf_1, 1 hit
TIGRFAMsⁱ	TIGR03449 mycothiol_MshA, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A1T3B5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRLATEPASL PSGLPEPRRV AVLSVHTSPL AQPGTGDAGG MNVYVLQTAL 
        60         70         80         90        100
ELANRGVDVE IFTRATSSAD QPVVPVAPGV LVRNVVAGPF EGLDKNDLPT 
       110        120        130        140        150
QLCAFTAGVL RAEATHEPGY YDIVHSHYWL SGQVGWLAAD RWAVPLVHTA 
       160        170        180        190        200
HTLAAVKNAS LAAGDAPEPP MRSIGEQQVV DAADRLIVNT EHEAQQLVSL 
       210        220        230        240        250
HQADPARIDV VHPGVDLATF TPGDRLAARA ALGLDANSRI VAFVGRIQPL 
       260        270        280        290        300
KAPDVLLRAA ALLPDVQVLI AGGPSGSGLI SRPGAGGLAT PDNLVNLAAE 
       310        320        330        340        350
LGMTDRVTFL PPQSRDNLVQ VYRAADVVAV PSYSESFGLV AVEAQACGTP 
       360        370        380        390        400
VVAAAVGGLP VAVRDGVSGA LVDGHDPGDW AGTLADVLAA DPATLSRAAV 
       410        420        430        440        450
DHAATFSWSH TVDALLAGYG RAIADHRARH QGQLARRSGR RFSMRRGVRA

Length:450

Mass (Da):46,802

Last modified:February 6, 2007 - v1

Checksum:ⁱ22BB995E57C26DA3

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000511 Genomic DNA Translation: ABM11665.1
NCBI Reference Sequences More...RefSeqⁱ	WP_011778101.1, NC_008726.1

Genome annotation databases

EnsemblBacteriaⁱ	ABM11665; ABM11665; Mvan_0827
KEGGⁱ	mva:Mvan_0827

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A1T3B5	UPI000567CC4C A0A1X1WST7 UPI0004666831 K0VC12	Mycobacterium austroafricanum Mycobacterium iranicum Mycobacterium vaccae ATCC 25954	450	UniRef90_A1T3B5	Cluster: D-inositol 3-phosphate glycosyltransferase	5

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A1T3B5	A4X1R6 UPI000488F925 UPI00039EAE30 UPI0004804857 UPI00036D03FD UPI0003670046 UPI0004713731 UPI0003774571 UPI000362D425 UPI0003745B78 +1262	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440) Salinispora pacifica Salinispora Salinispora tropica Cellulomonas marina Mycobacterium sp. M26 Thermostaphylospora chromogena Actinobacteria bacterium Nocardioides sp. Root224 Nocardioides sp. Root1257 And more	482	UniRef50_A4X1R6	Cluster: D-inositol 3-phosphate glycosyltransferase	1,273

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000511 Genomic DNA Translation: ABM11665.1
NCBI Reference Sequences More...RefSeqⁱ	WP_011778101.1, NC_008726.1

3D structure databases

ProteinModelPortalⁱ	A1T3B5
SMRⁱ	A1T3B5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	350058.Mvan_0827

STRINGⁱ

350058.Mvan_0827

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT4 Glycosyltransferase Family 4

CAZyⁱ

GT4 Glycosyltransferase Family 4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABM11665; ABM11665; Mvan_0827
KEGGⁱ	mva:Mvan_0827

Phylogenomic databases

eggNOGⁱ	ENOG4107R5M Bacteria COG0438 LUCA
HOGENOMⁱ	HOG000077288
KEGG Orthology (KO) More...KOⁱ	K15521
OMAⁱ	HTMAKVK
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0AO3

Enzyme and pathway databases

BioCycⁱ	MVAN350058:G1G7S-834-MONOMER

BioCycⁱ

MVAN350058:G1G7S-834-MONOMER

Family and domain databases

HAMAPⁱ	MF_01695 MshA, 1 hit
InterProⁱ	View protein in InterPro IPR001296 Glyco_trans_1 IPR028098 Glyco_trans_4-like_N IPR017814 Mycothiol_biosynthesis_MshA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13439 Glyco_transf_4, 1 hit PF00534 Glycos_transf_1, 1 hit
TIGRFAMsⁱ	TIGR03449 mycothiol_MshA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MSHA_MYCVP
Accessionⁱ	A1T3B5Primary (citable) accession number: A1T3B5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 2, 2010
	Last sequence update:	February 6, 2007
	Last modified:	February 28, 2018
	This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A1T3B5 (MSHA_MYCVP)

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D-inositol 3-phosphate glycosyltransferase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

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3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ