Reviewed, UniProtKB/Swiss-Prot A1T235 (IOLG1_MYCVP)

Names and origin

Protein names

Recommended name:
    Inositol 2-dehydrogenase 1
    EC=1.1.1.18
Alternative name(s):
    Myo-inositol 2-dehydrogenase 1
      Short name=MI 2-dehydrogenase 1

Gene names

Name:	iolG1
Ordered Locus Names:	Mvan_0387

Organism

Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [Complete proteome] [HAMAP]

Taxonomic identifier

350058 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Inositol 2-dehydrogenase 1 HAMAP MF_01671		PRO_0000352577

Sequences

	Sequence		Length	Mass (Da)
	A1T235-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: F578418C9B266947	FASTA	343	36,780
	10 20 30 40 50 60 MSEIGVAVLG VGLMGADHVA RIASRISGAR VAVVNDQVTE KAERLAATIT GCRAIADPLD 70 80 90 100 110 120 AIADRDVDAV VLATPGPTHE KQLLACLEHR KPVLCEKPLT TDVETSLEVV RREAELGVRL 130 140 150 160 170 180 IQVGFMRRFD DEYRALKALI DGGELGNPLV LHCVHRNPVV PGHFDSAMTV RDSLVHEVDV 190 200 210 220 230 240 TRFLFDEEIV SIQIVKPTPN SLAREGLFDP QIAILRTASG RHVDVELFVT TGVAYEVRTE 250 260 270 280 290 300 LVAEKGSVII GLDVGLVRKS APGTWGGTIT PSFKERFGQA YDTEIQRWVD AVRSGGTTGI 310 320 330 340 YTDGPTAWDG YAATAVCEAG VQALQSGQPV AVSMVDRVSI PGA

References

[1]

"Complete sequence of Mycobacterium vanbaalenii PYR-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000511 Genomic DNA. Translation: ABM11235.1.
RefSeq	YP_951241.1.
3D structure databases
SMR	A1T235. Positions 3-333.
ModBase	Search...
Protein-protein interaction databases
STRING	A1T235.
Genome annotation databases
GeneID	4645940.
GenomeReviews	Gene locus Mvan_0387 in contig CP000511_GR.
KEGG	mva:Mvan_0387.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HBG612336.
OMA	HESINNA.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG1_MYCVP

Accession

Primary (citable) accession number: A1T235

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	February 6, 2007
Last modified:	January 19, 2010
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)