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A1T1J8

- TRMB_MYCVP

UniProt

A1T1J8 - TRMB_MYCVP

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei96 – 961S-adenosyl-L-methionineUniRule annotation
    Binding sitei121 – 1211S-adenosyl-L-methionineUniRule annotation
    Binding sitei148 – 1481S-adenosyl-L-methionineUniRule annotation
    Active sitei171 – 1711By similarity
    Binding sitei171 – 1711S-adenosyl-L-methionineUniRule annotation
    Binding sitei175 – 1751SubstrateUniRule annotation
    Binding sitei207 – 2071SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciMVAN350058:GIWR-201-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:Mvan_0198
    OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
    Taxonomic identifieri350058 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000009159: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266tRNA (guanine-N(7)-)-methyltransferasePRO_0000288185Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi350058.Mvan_0198.

    Structurei

    3D structure databases

    ProteinModelPortaliA1T1J8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiLHIATDH.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1T1J8-1 [UniParc]FASTAAdd to Basket

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    MSDHGRMHIP ESGLATPAAA HSDDPPHPHF NRRVTSFRAR RSTISDAQQA    50
    TWDRLWPELG RQVRDGDAPA GRLDTTPAGR LDTEAWFGRH APVVLEIGCG 100
    TGTSTLAMAQ AEPDIDVVAV EVYRRGLAQL LSAMDREGVT NIRLIRGDGV 150
    DVLTHMFGPD SLTGVRVFFP DPWPKARHHK RRLLQPDTVA LIADRLRPGG 200
    ILHAATDHMG YAGHIAEVGD AEPRLRRIDP DDAGLPISTA RPVTKYQRKA 250
    LAGTEVAELL WEKTTP 266
    Length:266
    Mass (Da):29,174
    Last modified:February 6, 2007 - v1
    Checksum:iB777CC951F6FEEF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000511 Genomic DNA. Translation: ABM11048.1.
    RefSeqiWP_011777522.1. NC_008726.1.
    YP_951054.1. NC_008726.1.

    Genome annotation databases

    EnsemblBacteriaiABM11048; ABM11048; Mvan_0198.
    GeneIDi4647836.
    KEGGimva:Mvan_0198.
    PATRICi18178530. VBIMycVan31953_0201.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000511 Genomic DNA. Translation: ABM11048.1 .
    RefSeqi WP_011777522.1. NC_008726.1.
    YP_951054.1. NC_008726.1.

    3D structure databases

    ProteinModelPortali A1T1J8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 350058.Mvan_0198.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM11048 ; ABM11048 ; Mvan_0198 .
    GeneIDi 4647836.
    KEGGi mva:Mvan_0198.
    PATRICi 18178530. VBIMycVan31953_0201.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi LHIATDH.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci MVAN350058:GIWR-201-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 7251 / PYR-1.

    Entry informationi

    Entry nameiTRMB_MYCVP
    AccessioniPrimary (citable) accession number: A1T1J8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3