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A1SZJ2

- PUR9_PSYIN

UniProt

A1SZJ2 - PUR9_PSYIN

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Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, Ping_3220
Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciPING357804:GJBJ-3329-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Ping_3220
OrganismiPsychromonas ingrahamii (strain 37)
Taxonomic identifieri357804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
ProteomesiUP000000639: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_1000018943Add
BLAST

Proteomic databases

PRIDEiA1SZJ2.

Interactioni

Protein-protein interaction databases

STRINGi357804.Ping_3220.

Structurei

3D structure databases

ProteinModelPortaliA1SZJ2.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A1SZJ2-1 [UniParc]FASTAAdd to Basket

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MENSRPIKRA LLSVSDKAGI IEFAKELSAR GVEILSTGGT CKLLAENDIK    50
VTEVSDYTGF PEMMDGRVKT LHPKIHGGIL ARRGIDEVIM SENDIAPIDL 100
VVVNLYPFAE TVARPDCSLE DAIENIDIGG PTMVRAAAKN HKDVGIVVNA 150
GDYPRVLKEM QENNNSLAYK TRFDLAIAAY EHTAQYDGMI ANYFGTMVPS 200
YGENSEGDLE SKFPRTINMQ FKKKQDMRYG ENSHQSAAFY VEDDIQEASV 250
STATQLQGKA LSYNNIADTD AALECVKEFS EPACVIVKHS NPCGVAVAGN 300
ILDAYEGAYK TDPTSAFGGI IAFNRELDAK TAEAIVSRQF VEVIIAPSVS 350
PEAAKIVATK KNLRLLACGE WSDKTTQFDI KRVNGGLLVQ DRDQGMVGLE 400
DLKVVTKRQP TEAELKDLLF SWKVAKFVKS NAIVYVKNNA TVGVGAGQMS 450
RVYSAKVAGI KAADENLVVA GSVMSSDAFF PFRDGIDAAA EAGISCVIQP 500
GGSMRDNEVI AAADEHGMAM VFTGMRHFRH 530
Length:530
Mass (Da):57,477
Last modified:February 6, 2007 - v1
Checksum:i3DF9EAD835128656
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000510 Genomic DNA. Translation: ABM04907.1.
RefSeqiYP_944506.1. NC_008709.1.

Genome annotation databases

EnsemblBacteriaiABM04907; ABM04907; Ping_3220.
GeneIDi4624653.
KEGGipin:Ping_3220.
PATRICi23071961. VBIPsyIng103130_3559.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000510 Genomic DNA. Translation: ABM04907.1 .
RefSeqi YP_944506.1. NC_008709.1.

3D structure databases

ProteinModelPortali A1SZJ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357804.Ping_3220.

Proteomic databases

PRIDEi A1SZJ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM04907 ; ABM04907 ; Ping_3220 .
GeneIDi 4624653.
KEGGi pin:Ping_3220.
PATRICi 23071961. VBIPsyIng103130_3559.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci PING357804:GJBJ-3329-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 37.

Entry informationi

Entry nameiPUR9_PSYIN
AccessioniPrimary (citable) accession number: A1SZJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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