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A1SYV0

- LPXB_PSYIN

UniProt

A1SYV0 - LPXB_PSYIN

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciPING357804:GJBJ-3068-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:Ping_2963
    OrganismiPsychromonas ingrahamii (strain 37)
    Taxonomic identifieri357804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
    ProteomesiUP000000639: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 381381Lipid-A-disaccharide synthasePRO_1000060773Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi357804.Ping_2963.

    Structurei

    3D structure databases

    ProteinModelPortaliA1SYV0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1SYV0-1 [UniParc]FASTAAdd to Basket

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    MNKPLRIGLI AGEASGDILG EGLIKALKIH YPDAVFEGIA GPKMIAQGCT    50
    ALHPLEALSV MGFVEVLGKL GSILRIRKSI INHFIANPPD IFIGIDAPDF 100
    NLTVELKLKQ HNIKTIHYVS PSVWAWKQWR IHKIAKATDL VLAFLPFEKA 150
    FYDRFDVPCR FIGHTLADQL PLEPEKQQAR QSLGLQADAK LLAILPGSRK 200
    AEVEILGPIF LQSAALISRQ YPDYKFIVPM VNGARKKQLL EQQQQYAPDL 250
    PLQIFDGQAS AVLQSADAVL LASGTAALEA MLAKVPMVVA YKVNLLTYVI 300
    AKALVKVKYT SLPNLIADKE IVKELSQYNC TVENIVAALQ PLLGQDNHQM 350
    INTFIRLHKL IRCDADRQAA QAVVDVLNNK K 381
    Length:381
    Mass (Da):42,087
    Last modified:February 6, 2007 - v1
    Checksum:i051BADD944B89184
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000510 Genomic DNA. Translation: ABM04665.1.
    RefSeqiWP_011771219.1. NC_008709.1.
    YP_944264.1. NC_008709.1.

    Genome annotation databases

    EnsemblBacteriaiABM04665; ABM04665; Ping_2963.
    GeneIDi4623479.
    KEGGipin:Ping_2963.
    PATRICi23071379. VBIPsyIng103130_3272.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000510 Genomic DNA. Translation: ABM04665.1 .
    RefSeqi WP_011771219.1. NC_008709.1.
    YP_944264.1. NC_008709.1.

    3D structure databases

    ProteinModelPortali A1SYV0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357804.Ping_2963.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM04665 ; ABM04665 ; Ping_2963 .
    GeneIDi 4623479.
    KEGGi pin:Ping_2963.
    PATRICi 23071379. VBIPsyIng103130_3272.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci PING357804:GJBJ-3068-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 37.

    Entry informationi

    Entry nameiLPXB_PSYIN
    AccessioniPrimary (citable) accession number: A1SYV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3