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A1SYV0

- LPXB_PSYIN

UniProt

A1SYV0 - LPXB_PSYIN

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, Ping_2963
Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciPING357804:GJBJ-3068-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Ping_2963
OrganismiPsychromonas ingrahamii (strain 37)
Taxonomic identifieri357804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
ProteomesiUP000000639: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Lipid-A-disaccharide synthaseUniRule annotationPRO_1000060773Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi357804.Ping_2963.

Structurei

3D structure databases

ProteinModelPortaliA1SYV0.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A1SYV0-1 [UniParc]FASTAAdd to Basket

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MNKPLRIGLI AGEASGDILG EGLIKALKIH YPDAVFEGIA GPKMIAQGCT    50
ALHPLEALSV MGFVEVLGKL GSILRIRKSI INHFIANPPD IFIGIDAPDF 100
NLTVELKLKQ HNIKTIHYVS PSVWAWKQWR IHKIAKATDL VLAFLPFEKA 150
FYDRFDVPCR FIGHTLADQL PLEPEKQQAR QSLGLQADAK LLAILPGSRK 200
AEVEILGPIF LQSAALISRQ YPDYKFIVPM VNGARKKQLL EQQQQYAPDL 250
PLQIFDGQAS AVLQSADAVL LASGTAALEA MLAKVPMVVA YKVNLLTYVI 300
AKALVKVKYT SLPNLIADKE IVKELSQYNC TVENIVAALQ PLLGQDNHQM 350
INTFIRLHKL IRCDADRQAA QAVVDVLNNK K 381
Length:381
Mass (Da):42,087
Last modified:February 6, 2007 - v1
Checksum:i051BADD944B89184
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000510 Genomic DNA. Translation: ABM04665.1.
RefSeqiWP_011771219.1. NC_008709.1.
YP_944264.1. NC_008709.1.

Genome annotation databases

EnsemblBacteriaiABM04665; ABM04665; Ping_2963.
GeneIDi4623479.
KEGGipin:Ping_2963.
PATRICi23071379. VBIPsyIng103130_3272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000510 Genomic DNA. Translation: ABM04665.1 .
RefSeqi WP_011771219.1. NC_008709.1.
YP_944264.1. NC_008709.1.

3D structure databases

ProteinModelPortali A1SYV0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357804.Ping_2963.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM04665 ; ABM04665 ; Ping_2963 .
GeneIDi 4623479.
KEGGi pin:Ping_2963.
PATRICi 23071379. VBIPsyIng103130_3272.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci PING357804:GJBJ-3068-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 37.

Entry informationi

Entry nameiLPXB_PSYIN
AccessioniPrimary (citable) accession number: A1SYV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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