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A1SYK5 (TYPH_PSYIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
Ordered Locus Names:Ping_2865
OrganismPsychromonas ingrahamii (strain 37) [Complete proteome] [HAMAP]
Taxonomic identifier357804 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis By similarity. HAMAP-Rule MF_01628

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01628

Pathway

Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. HAMAP-Rule MF_01628

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01628

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446Thymidine phosphorylase HAMAP-Rule MF_01628
PRO_0000335774

Sequences

Sequence LengthMass (Da)Tools
A1SYK5 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 8179E1A439D638BA

FASTA44647,206
        10         20         30         40         50         60 
MILLPQEIIR NKRDGKTLSR QEIDFFIKGI TDNSVTEGQI AAFAMAVYFQ DMNMDERVLL 

        70         80         90        100        110        120 
VSAMRDSGQV INWQSLNLNG PVVDKHSTGG VGDVTSLILG PMVAACGGYV PMISGRGLGH 

       130        140        150        160        170        180 
TGGTLDKLDA ISGYKTTPDS LDHFRKIVKE VGVAIIGQTG DLAPADKRFY ATRDITATVE 

       190        200        210        220        230        240 
SIPLITASIL SKKLAAGIDA LVMDVKAGSG AFMPTFEQSE ALANSIVGVA NGAGCKTSAL 

       250        260        270        280        290        300 
ITNMDQVLAS SAGNAVEVRE AVRFLKGEVV NPRLHEVTMA LCAEMLLLSG LAADIKEAQA 

       310        320        330        340        350        360 
KLQKVLDNGK AAEVFAKMVG ALGGPADFIE NQDNYLQKSA IVRPVYAQHS GIVQSMDTRA 

       370        380        390        400        410        420 
LGMAVVNLGG GRHSASDSID YAVGLSGILS LGESADSEKP LAMIHAQSEK QFSEAQRAIQ 

       430        440 
SAIICGTDSL QAQTQVYRHI RLPDIS 

« Hide

References

[1]"Complete sequence of Psychromonas ingrahamii 37."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Ivanova N., Staley J., Richardson P.
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 37.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000510 Genomic DNA. Translation: ABM04570.1.
RefSeqYP_944169.1. NC_008709.1.

3D structure databases

ProteinModelPortalA1SYK5.
SMRA1SYK5. Positions 2-440.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING357804.Ping_2865.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM04570; ABM04570; Ping_2865.
GeneID4625647.
KEGGpin:Ping_2865.
PATRIC23071165. VBIPsyIng103130_3165.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0213.
HOGENOMHOG000047313.
KOK00758.
OMAFINGVRD.
OrthoDBEOG61ZTGG.

Enzyme and pathway databases

BioCycPING357804:GJBJ-2970-MONOMER.
UniPathwayUPA00578; UER00638.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_01628. Thymid_phosp.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_PSYIN
AccessionPrimary (citable) accession number: A1SYK5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways