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A1SY74

- GCSP_PSYIN

UniProt

A1SY74 - GCSP_PSYIN

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Ping_2729
Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPING357804:GJBJ-2831-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Ping_2729
OrganismiPsychromonas ingrahamii (strain 37)
Taxonomic identifieri357804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
ProteomesiUP000000639: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 966966Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000045597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei713 – 7131N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi357804.Ping_2729.

Structurei

3D structure databases

ProteinModelPortaliA1SY74.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiQPANEEQ.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A1SY74-1 [UniParc]FASTAAdd to Basket

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MTDTTLLDLL SDSKEFATRH NGSGAAQQKK MLETIGVQSI EQLIDQTVPA    50
AIRLPEKMKL AEPQSESMTL ASLKAIAEKN IVNRSFIGQG YYNTLLPNVI 100
LRNVLENPGW YTAYTPYQPE ISQGRLESLL NYQQMVMDLT AMEIANASLL 150
DEATAAAESM TLCKRAGKSK SLAFFVADGI HPQTVDVVRT RAEFFGYEII 200
SGSMEDLDNH DLFGALLQYP STTGNIQDLT AIIEKAHAKK TLVSVASDLL 250
ALTLLKAPGE MGADIVIGSA QRFGIPMGFG GPHAGFMATK EKFKRTMPGR 300
IIGVSKDSKG KPALRMAMQT REQHIRREKA TSNICTAQAL LANMSAFYAL 350
YHGPEGLRKI ARRVHHLTAI LVAGLRSEGF ELANQHFFDT ITLNSNEHSK 400
AIYHRALAEG MNLRKFPTPD NMPVQLGISL DETTTITDVE DLLRVITGKA 450
LSSAGFAAQV AEDEFAGIPA TCRRRSKYLT HPIFNEHHSE TQMMRYMKKL 500
ENKDYSLTHG MIPLGCCTMK LNAAALMLPV SWPEFSQMHP FAPTEQSFGY 550
QELAEKLSKM LCEVTGYDGF SLQPNSGAQG EYAGLIAIHR YHQSNGEDQR 600
NICLIPSSAH GTNPATASML SMKVVVVGCD QQGNIDHADL KAKIDKHRDN 650
LSCIMVTYPS THGIYEEGIQ EICEWVHEAG GQVYLDGANM NAQIGLTSPG 700
FIGSDVSHLN LHKTFCIPHG GGGPGMGPIG VKKHLIPFLP GHIEVTESAD 750
NKHYAVSAAE LGSASILPIS YAYIAMMGEQ GLTSATQIAI LNANYIMERL 800
RPHYPILYQG KEGRVAHECI IDIRPLEAAS GISNEDIAKR LMDYGFHAPT 850
MSFPVGGTFM IEPTESESTA ELDRFCDAMI AIRHEIKQIE DGEWSATDNP 900
LVNAPHTQVD LMESEWTHGY SRELACFPSK HSKDSKYWPT VNRVDNVFGD 950
RNLICSCPSI ESYMEE 966
Length:966
Mass (Da):106,258
Last modified:February 6, 2007 - v1
Checksum:iDFDCB94018300327
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000510 Genomic DNA. Translation: ABM04439.1.
RefSeqiWP_011770994.1. NC_008709.1.
YP_944038.1. NC_008709.1.

Genome annotation databases

EnsemblBacteriaiABM04439; ABM04439; Ping_2729.
GeneIDi4626391.
KEGGipin:Ping_2729.
PATRICi23070859. VBIPsyIng103130_3015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000510 Genomic DNA. Translation: ABM04439.1 .
RefSeqi WP_011770994.1. NC_008709.1.
YP_944038.1. NC_008709.1.

3D structure databases

ProteinModelPortali A1SY74.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357804.Ping_2729.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM04439 ; ABM04439 ; Ping_2729 .
GeneIDi 4626391.
KEGGi pin:Ping_2729.
PATRICi 23070859. VBIPsyIng103130_3015.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi QPANEEQ.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PING357804:GJBJ-2831-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 37.

Entry informationi

Entry nameiGCSP_PSYIN
AccessioniPrimary (citable) accession number: A1SY74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi