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A1SY74

- GCSP_PSYIN

UniProt

A1SY74 - GCSP_PSYIN

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPING357804:GJBJ-2831-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Ping_2729
    OrganismiPsychromonas ingrahamii (strain 37)
    Taxonomic identifieri357804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
    ProteomesiUP000000639: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 966966Glycine dehydrogenase (decarboxylating)PRO_1000045597Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei713 – 7131N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi357804.Ping_2729.

    Structurei

    3D structure databases

    ProteinModelPortaliA1SY74.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiQPANEEQ.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1SY74-1 [UniParc]FASTAAdd to Basket

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    MTDTTLLDLL SDSKEFATRH NGSGAAQQKK MLETIGVQSI EQLIDQTVPA    50
    AIRLPEKMKL AEPQSESMTL ASLKAIAEKN IVNRSFIGQG YYNTLLPNVI 100
    LRNVLENPGW YTAYTPYQPE ISQGRLESLL NYQQMVMDLT AMEIANASLL 150
    DEATAAAESM TLCKRAGKSK SLAFFVADGI HPQTVDVVRT RAEFFGYEII 200
    SGSMEDLDNH DLFGALLQYP STTGNIQDLT AIIEKAHAKK TLVSVASDLL 250
    ALTLLKAPGE MGADIVIGSA QRFGIPMGFG GPHAGFMATK EKFKRTMPGR 300
    IIGVSKDSKG KPALRMAMQT REQHIRREKA TSNICTAQAL LANMSAFYAL 350
    YHGPEGLRKI ARRVHHLTAI LVAGLRSEGF ELANQHFFDT ITLNSNEHSK 400
    AIYHRALAEG MNLRKFPTPD NMPVQLGISL DETTTITDVE DLLRVITGKA 450
    LSSAGFAAQV AEDEFAGIPA TCRRRSKYLT HPIFNEHHSE TQMMRYMKKL 500
    ENKDYSLTHG MIPLGCCTMK LNAAALMLPV SWPEFSQMHP FAPTEQSFGY 550
    QELAEKLSKM LCEVTGYDGF SLQPNSGAQG EYAGLIAIHR YHQSNGEDQR 600
    NICLIPSSAH GTNPATASML SMKVVVVGCD QQGNIDHADL KAKIDKHRDN 650
    LSCIMVTYPS THGIYEEGIQ EICEWVHEAG GQVYLDGANM NAQIGLTSPG 700
    FIGSDVSHLN LHKTFCIPHG GGGPGMGPIG VKKHLIPFLP GHIEVTESAD 750
    NKHYAVSAAE LGSASILPIS YAYIAMMGEQ GLTSATQIAI LNANYIMERL 800
    RPHYPILYQG KEGRVAHECI IDIRPLEAAS GISNEDIAKR LMDYGFHAPT 850
    MSFPVGGTFM IEPTESESTA ELDRFCDAMI AIRHEIKQIE DGEWSATDNP 900
    LVNAPHTQVD LMESEWTHGY SRELACFPSK HSKDSKYWPT VNRVDNVFGD 950
    RNLICSCPSI ESYMEE 966
    Length:966
    Mass (Da):106,258
    Last modified:February 6, 2007 - v1
    Checksum:iDFDCB94018300327
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000510 Genomic DNA. Translation: ABM04439.1.
    RefSeqiWP_011770994.1. NC_008709.1.
    YP_944038.1. NC_008709.1.

    Genome annotation databases

    EnsemblBacteriaiABM04439; ABM04439; Ping_2729.
    GeneIDi4626391.
    KEGGipin:Ping_2729.
    PATRICi23070859. VBIPsyIng103130_3015.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000510 Genomic DNA. Translation: ABM04439.1 .
    RefSeqi WP_011770994.1. NC_008709.1.
    YP_944038.1. NC_008709.1.

    3D structure databases

    ProteinModelPortali A1SY74.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357804.Ping_2729.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM04439 ; ABM04439 ; Ping_2729 .
    GeneIDi 4626391.
    KEGGi pin:Ping_2729.
    PATRICi 23070859. VBIPsyIng103130_3015.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi QPANEEQ.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci PING357804:GJBJ-2831-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 37.

    Entry informationi

    Entry nameiGCSP_PSYIN
    AccessioniPrimary (citable) accession number: A1SY74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3