Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A1SY74

- GCSP_PSYIN

UniProt

A1SY74 - GCSP_PSYIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPING357804:GJBJ-2831-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Ping_2729
OrganismiPsychromonas ingrahamii (strain 37)
Taxonomic identifieri357804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
ProteomesiUP000000639: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 966966Glycine dehydrogenase (decarboxylating)PRO_1000045597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei713 – 7131N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi357804.Ping_2729.

Structurei

3D structure databases

ProteinModelPortaliA1SY74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiQPANEEQ.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A1SY74-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDTTLLDLL SDSKEFATRH NGSGAAQQKK MLETIGVQSI EQLIDQTVPA
60 70 80 90 100
AIRLPEKMKL AEPQSESMTL ASLKAIAEKN IVNRSFIGQG YYNTLLPNVI
110 120 130 140 150
LRNVLENPGW YTAYTPYQPE ISQGRLESLL NYQQMVMDLT AMEIANASLL
160 170 180 190 200
DEATAAAESM TLCKRAGKSK SLAFFVADGI HPQTVDVVRT RAEFFGYEII
210 220 230 240 250
SGSMEDLDNH DLFGALLQYP STTGNIQDLT AIIEKAHAKK TLVSVASDLL
260 270 280 290 300
ALTLLKAPGE MGADIVIGSA QRFGIPMGFG GPHAGFMATK EKFKRTMPGR
310 320 330 340 350
IIGVSKDSKG KPALRMAMQT REQHIRREKA TSNICTAQAL LANMSAFYAL
360 370 380 390 400
YHGPEGLRKI ARRVHHLTAI LVAGLRSEGF ELANQHFFDT ITLNSNEHSK
410 420 430 440 450
AIYHRALAEG MNLRKFPTPD NMPVQLGISL DETTTITDVE DLLRVITGKA
460 470 480 490 500
LSSAGFAAQV AEDEFAGIPA TCRRRSKYLT HPIFNEHHSE TQMMRYMKKL
510 520 530 540 550
ENKDYSLTHG MIPLGCCTMK LNAAALMLPV SWPEFSQMHP FAPTEQSFGY
560 570 580 590 600
QELAEKLSKM LCEVTGYDGF SLQPNSGAQG EYAGLIAIHR YHQSNGEDQR
610 620 630 640 650
NICLIPSSAH GTNPATASML SMKVVVVGCD QQGNIDHADL KAKIDKHRDN
660 670 680 690 700
LSCIMVTYPS THGIYEEGIQ EICEWVHEAG GQVYLDGANM NAQIGLTSPG
710 720 730 740 750
FIGSDVSHLN LHKTFCIPHG GGGPGMGPIG VKKHLIPFLP GHIEVTESAD
760 770 780 790 800
NKHYAVSAAE LGSASILPIS YAYIAMMGEQ GLTSATQIAI LNANYIMERL
810 820 830 840 850
RPHYPILYQG KEGRVAHECI IDIRPLEAAS GISNEDIAKR LMDYGFHAPT
860 870 880 890 900
MSFPVGGTFM IEPTESESTA ELDRFCDAMI AIRHEIKQIE DGEWSATDNP
910 920 930 940 950
LVNAPHTQVD LMESEWTHGY SRELACFPSK HSKDSKYWPT VNRVDNVFGD
960
RNLICSCPSI ESYMEE
Length:966
Mass (Da):106,258
Last modified:February 6, 2007 - v1
Checksum:iDFDCB94018300327
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000510 Genomic DNA. Translation: ABM04439.1.
RefSeqiYP_944038.1. NC_008709.1.

Genome annotation databases

EnsemblBacteriaiABM04439; ABM04439; Ping_2729.
GeneIDi4626391.
KEGGipin:Ping_2729.
PATRICi23070859. VBIPsyIng103130_3015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000510 Genomic DNA. Translation: ABM04439.1 .
RefSeqi YP_944038.1. NC_008709.1.

3D structure databases

ProteinModelPortali A1SY74.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357804.Ping_2729.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM04439 ; ABM04439 ; Ping_2729 .
GeneIDi 4626391.
KEGGi pin:Ping_2729.
PATRICi 23070859. VBIPsyIng103130_3015.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi QPANEEQ.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PING357804:GJBJ-2831-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 37.

Entry informationi

Entry nameiGCSP_PSYIN
AccessioniPrimary (citable) accession number: A1SY74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3