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A1SWB8

- BGAL_PSYIN

UniProt

A1SWB8 - BGAL_PSYIN

Protein

Beta-galactosidase

Gene

lacZ

Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotation

    Cofactori

    Binds 2 magnesium ions per monomer.UniRule annotation
    Binds 1 sodium ion per monomer.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei101 – 1011SubstrateUniRule annotation
    Metal bindingi199 – 1991SodiumUniRule annotation
    Binding sitei199 – 1991SubstrateUniRule annotation
    Sitei356 – 3561Transition state stabilizerUniRule annotation
    Sitei390 – 3901Transition state stabilizerUniRule annotation
    Metal bindingi415 – 4151Magnesium 1UniRule annotation
    Metal bindingi417 – 4171Magnesium 1UniRule annotation
    Active sitei460 – 4601Proton donorUniRule annotation
    Metal bindingi460 – 4601Magnesium 1UniRule annotation
    Binding sitei460 – 4601SubstrateUniRule annotation
    Active sitei540 – 5401NucleophileUniRule annotation
    Metal bindingi600 – 6001Magnesium 2UniRule annotation
    Metal bindingi604 – 6041Sodium; via carbonyl oxygenUniRule annotation
    Metal bindingi607 – 6071SodiumUniRule annotation
    Binding sitei607 – 6071SubstrateUniRule annotation
    Binding sitei1011 – 10111SubstrateUniRule annotation

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC
    2. carbohydrate binding Source: InterPro
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Ligandi

    Magnesium, Metal-binding, Sodium

    Enzyme and pathway databases

    BioCyciPING357804:GJBJ-2105-MONOMER.

    Protein family/group databases

    CAZyiGH2. Glycoside Hydrolase Family 2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-galactosidaseUniRule annotation (EC:3.2.1.23UniRule annotation)
    Short name:
    Beta-galUniRule annotation
    Alternative name(s):
    LactaseUniRule annotation
    Gene namesi
    Name:lacZUniRule annotation
    Ordered Locus Names:Ping_2019
    OrganismiPsychromonas ingrahamii (strain 37)
    Taxonomic identifieri357804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
    ProteomesiUP000000639: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. beta-galactosidase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10351035Beta-galactosidasePRO_0000367006Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi357804.Ping_2019.

    Structurei

    3D structure databases

    ProteinModelPortaliA1SWB8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni540 – 5434Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3250.
    HOGENOMiHOG000252443.
    KOiK01190.
    OMAiDPKKPYI.
    OrthoDBiEOG6XWV0T.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    2.60.40.320. 2 hits.
    2.70.98.10. 1 hit.
    3.20.20.80. 1 hit.
    HAMAPiMF_01687. Beta_gal.
    InterProiIPR004199. B-gal_small/dom_5.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR008979. Galactose-bd-like.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023933. Glyco_hydro_2_beta_Galsidase.
    IPR023230. Glyco_hydro_2_CS.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF02929. Bgal_small_N. 1 hit.
    PF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view]
    PRINTSiPR00132. GLHYDRLASE2.
    SMARTiSM01038. Bgal_small_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    SSF74650. SSF74650. 1 hit.
    PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
    PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1SWB8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MREFSEIIKA RDWENQEVTH QHVVQAHAPL HAFHSKQAAL DNQASEFQQL     50
    LNGQWRFQLF AKPEAVPNHC INIDFDDSAW SDITVPSNWQ LQGYDKPIYT 100
    NVKYPFADNP PFVPADNPTG VYRLNFTLPT AWKERKNTVI FDGVNSAFHL 150
    WCNGIWVGYS QDSRLPAEFD LSCHLQAGDN QLTVMVLRWS DGSYLEDQDM 200
    WWLSGIFRDV CLLSKPLISI RDITVSTELD ACFNHGSINV VTQLSEQSSQ 250
    YTAQVQLFDA QLQPVTKLVG APFGERMIDE KGPANDRAEH KIAVPSPHKW 300
    SSESPYLYRV VISLVDNEGQ VVDSEAYQVG FRVVEMSNGQ LKLNGEALLI 350
    RGVNRHEHHP EKGHAISYED MLVDIKLLKQ NNFNAVRTAH YPNHPLWYEL 400
    CDQYGLYVVD EANLETHGQF PMSRLSNDLS WLNAYMRRMT RMVERDKNHP 450
    SIIIWSLGNE SGLGHHHHAM YQWTKRRDPT RPVQYEGGGA DTAATDIIVP 500
    MYARVNKDIT LPNAPDVVPK MAIKKWLSMP NEQRPLILCE YAHAMGNSLG 550
    SFDKYWQAFR EYPRLQGGFI WDWVDQGLTK IDDNGDNYWA YGGDFGDQIN 600
    DRQFCINGLV FPDRSLHPTV YEAKKAQQFY QFSLVDGDQL KVKIDSENLF 650
    IESMDETLCW SVTEAGYVIA SGEMELHVTA QSSKILTLLE SYPEQKIGCD 700
    YFLNIEIVLN KDKPWATKGF VVATEQVALA SIAQLTNVPL IESGAPRLSE 750
    DKNKITVAGT GSGAEFELEI DKQQGVISQW LVRGENKILQ GPKDNFFRAP 800
    LDNDIGTSEA DCIDPNAWVT QWDTAGIANL VPHCIAIEAV TLARSVLVKV 850
    EFGHYVENKL LISSHWQYTI NNQGEVQIDV NVNLAKSLSP LPRIGLELIL 900
    PDSEKPVNWF GRGPHENYPD RILSAHIARH CCSIEEMHTP YIFPSENGLR 950
    CDVKDAIVGD LTVSGDFHLA VSRYSQMNIA QAKHVNDLIN DHQLYVRLDA 1000
    FHMGVGGDDS WSPSVHDEFL LNKEHYHYQM ILAFN 1035
    Length:1,035
    Mass (Da):117,460
    Last modified:February 6, 2007 - v1
    Checksum:iEFBFDF2F17314885
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000510 Genomic DNA. Translation: ABM03783.1.
    RefSeqiYP_943382.1. NC_008709.1.

    Genome annotation databases

    EnsemblBacteriaiABM03783; ABM03783; Ping_2019.
    GeneIDi4624702.
    KEGGipin:Ping_2019.
    PATRICi23069241. VBIPsyIng103130_2222.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000510 Genomic DNA. Translation: ABM03783.1 .
    RefSeqi YP_943382.1. NC_008709.1.

    3D structure databases

    ProteinModelPortali A1SWB8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357804.Ping_2019.

    Protein family/group databases

    CAZyi GH2. Glycoside Hydrolase Family 2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM03783 ; ABM03783 ; Ping_2019 .
    GeneIDi 4624702.
    KEGGi pin:Ping_2019.
    PATRICi 23069241. VBIPsyIng103130_2222.

    Phylogenomic databases

    eggNOGi COG3250.
    HOGENOMi HOG000252443.
    KOi K01190.
    OMAi DPKKPYI.
    OrthoDBi EOG6XWV0T.

    Enzyme and pathway databases

    BioCyci PING357804:GJBJ-2105-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    2.60.40.320. 2 hits.
    2.70.98.10. 1 hit.
    3.20.20.80. 1 hit.
    HAMAPi MF_01687. Beta_gal.
    InterProi IPR004199. B-gal_small/dom_5.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR008979. Galactose-bd-like.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023933. Glyco_hydro_2_beta_Galsidase.
    IPR023230. Glyco_hydro_2_CS.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF02929. Bgal_small_N. 1 hit.
    PF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00132. GLHYDRLASE2.
    SMARTi SM01038. Bgal_small_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    SSF74650. SSF74650. 1 hit.
    PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
    PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 37.

    Entry informationi

    Entry nameiBGAL_PSYIN
    AccessioniPrimary (citable) accession number: A1SWB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3