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A1SWB8

- BGAL_PSYIN

UniProt

A1SWB8 - BGAL_PSYIN

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Protein

Beta-galactosidase

Gene

lacZ

Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotation

Cofactori

Binds 2 magnesium ions per monomer.UniRule annotation
Binds 1 sodium ion per monomer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei101 – 1011SubstrateUniRule annotation
Metal bindingi199 – 1991SodiumUniRule annotation
Binding sitei199 – 1991SubstrateUniRule annotation
Sitei356 – 3561Transition state stabilizerUniRule annotation
Sitei390 – 3901Transition state stabilizerUniRule annotation
Metal bindingi415 – 4151Magnesium 1UniRule annotation
Metal bindingi417 – 4171Magnesium 1UniRule annotation
Active sitei460 – 4601Proton donorUniRule annotation
Metal bindingi460 – 4601Magnesium 1UniRule annotation
Binding sitei460 – 4601SubstrateUniRule annotation
Active sitei540 – 5401NucleophileUniRule annotation
Metal bindingi600 – 6001Magnesium 2UniRule annotation
Metal bindingi604 – 6041Sodium; via carbonyl oxygenUniRule annotation
Metal bindingi607 – 6071SodiumUniRule annotation
Binding sitei607 – 6071SubstrateUniRule annotation
Binding sitei1011 – 10111SubstrateUniRule annotation

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Sodium

Enzyme and pathway databases

BioCyciPING357804:GJBJ-2105-MONOMER.

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidaseUniRule annotation (EC:3.2.1.23UniRule annotation)
Short name:
Beta-galUniRule annotation
Alternative name(s):
LactaseUniRule annotation
Gene namesi
Name:lacZUniRule annotation
Ordered Locus Names:Ping_2019
OrganismiPsychromonas ingrahamii (strain 37)
Taxonomic identifieri357804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
ProteomesiUP000000639: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. beta-galactosidase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10351035Beta-galactosidasePRO_0000367006Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi357804.Ping_2019.

Structurei

3D structure databases

ProteinModelPortaliA1SWB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni540 – 5434Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000252443.
KOiK01190.
OMAiDPKKPYI.
OrthoDBiEOG6XWV0T.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPiMF_01687. Beta_gal.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1SWB8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MREFSEIIKA RDWENQEVTH QHVVQAHAPL HAFHSKQAAL DNQASEFQQL
60 70 80 90 100
LNGQWRFQLF AKPEAVPNHC INIDFDDSAW SDITVPSNWQ LQGYDKPIYT
110 120 130 140 150
NVKYPFADNP PFVPADNPTG VYRLNFTLPT AWKERKNTVI FDGVNSAFHL
160 170 180 190 200
WCNGIWVGYS QDSRLPAEFD LSCHLQAGDN QLTVMVLRWS DGSYLEDQDM
210 220 230 240 250
WWLSGIFRDV CLLSKPLISI RDITVSTELD ACFNHGSINV VTQLSEQSSQ
260 270 280 290 300
YTAQVQLFDA QLQPVTKLVG APFGERMIDE KGPANDRAEH KIAVPSPHKW
310 320 330 340 350
SSESPYLYRV VISLVDNEGQ VVDSEAYQVG FRVVEMSNGQ LKLNGEALLI
360 370 380 390 400
RGVNRHEHHP EKGHAISYED MLVDIKLLKQ NNFNAVRTAH YPNHPLWYEL
410 420 430 440 450
CDQYGLYVVD EANLETHGQF PMSRLSNDLS WLNAYMRRMT RMVERDKNHP
460 470 480 490 500
SIIIWSLGNE SGLGHHHHAM YQWTKRRDPT RPVQYEGGGA DTAATDIIVP
510 520 530 540 550
MYARVNKDIT LPNAPDVVPK MAIKKWLSMP NEQRPLILCE YAHAMGNSLG
560 570 580 590 600
SFDKYWQAFR EYPRLQGGFI WDWVDQGLTK IDDNGDNYWA YGGDFGDQIN
610 620 630 640 650
DRQFCINGLV FPDRSLHPTV YEAKKAQQFY QFSLVDGDQL KVKIDSENLF
660 670 680 690 700
IESMDETLCW SVTEAGYVIA SGEMELHVTA QSSKILTLLE SYPEQKIGCD
710 720 730 740 750
YFLNIEIVLN KDKPWATKGF VVATEQVALA SIAQLTNVPL IESGAPRLSE
760 770 780 790 800
DKNKITVAGT GSGAEFELEI DKQQGVISQW LVRGENKILQ GPKDNFFRAP
810 820 830 840 850
LDNDIGTSEA DCIDPNAWVT QWDTAGIANL VPHCIAIEAV TLARSVLVKV
860 870 880 890 900
EFGHYVENKL LISSHWQYTI NNQGEVQIDV NVNLAKSLSP LPRIGLELIL
910 920 930 940 950
PDSEKPVNWF GRGPHENYPD RILSAHIARH CCSIEEMHTP YIFPSENGLR
960 970 980 990 1000
CDVKDAIVGD LTVSGDFHLA VSRYSQMNIA QAKHVNDLIN DHQLYVRLDA
1010 1020 1030
FHMGVGGDDS WSPSVHDEFL LNKEHYHYQM ILAFN
Length:1,035
Mass (Da):117,460
Last modified:February 6, 2007 - v1
Checksum:iEFBFDF2F17314885
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000510 Genomic DNA. Translation: ABM03783.1.
RefSeqiYP_943382.1. NC_008709.1.

Genome annotation databases

EnsemblBacteriaiABM03783; ABM03783; Ping_2019.
GeneIDi4624702.
KEGGipin:Ping_2019.
PATRICi23069241. VBIPsyIng103130_2222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000510 Genomic DNA. Translation: ABM03783.1 .
RefSeqi YP_943382.1. NC_008709.1.

3D structure databases

ProteinModelPortali A1SWB8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357804.Ping_2019.

Protein family/group databases

CAZyi GH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM03783 ; ABM03783 ; Ping_2019 .
GeneIDi 4624702.
KEGGi pin:Ping_2019.
PATRICi 23069241. VBIPsyIng103130_2222.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000252443.
KOi K01190.
OMAi DPKKPYI.
OrthoDBi EOG6XWV0T.

Enzyme and pathway databases

BioCyci PING357804:GJBJ-2105-MONOMER.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPi MF_01687. Beta_gal.
InterProi IPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
PRINTSi PR00132. GLHYDRLASE2.
SMARTi SM01038. Bgal_small_N. 1 hit.
[Graphical view ]
SUPFAMi SSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 37.

Entry informationi

Entry nameiBGAL_PSYIN
AccessioniPrimary (citable) accession number: A1SWB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 6, 2007
Last modified: October 1, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3