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A1SWB8

- BGAL_PSYIN

UniProt

A1SWB8 - BGAL_PSYIN

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Protein

Beta-galactosidase

Gene
lacZ, Ping_2019
Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotation

Cofactori

Binds 2 magnesium ions per monomer By similarity.UniRule annotation
Binds 1 sodium ion per monomer By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei101 – 1011Substrate By similarity
Metal bindingi199 – 1991Sodium By similarity
Binding sitei199 – 1991Substrate By similarity
Sitei356 – 3561Transition state stabilizer By similarity
Sitei390 – 3901Transition state stabilizer By similarity
Metal bindingi415 – 4151Magnesium 1 By similarity
Metal bindingi417 – 4171Magnesium 1 By similarity
Active sitei460 – 4601Proton donor By similarity
Metal bindingi460 – 4601Magnesium 1 By similarity
Binding sitei460 – 4601Substrate By similarity
Active sitei540 – 5401Nucleophile By similarity
Metal bindingi600 – 6001Magnesium 2 By similarity
Metal bindingi604 – 6041Sodium; via carbonyl oxygen By similarity
Metal bindingi607 – 6071Sodium By similarity
Binding sitei607 – 6071Substrate By similarity
Binding sitei1011 – 10111Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Sodium

Enzyme and pathway databases

BioCyciPING357804:GJBJ-2105-MONOMER.

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Short name:
Beta-gal
Alternative name(s):
Lactase
Gene namesi
Name:lacZ
Ordered Locus Names:Ping_2019
OrganismiPsychromonas ingrahamii (strain 37)
Taxonomic identifieri357804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
ProteomesiUP000000639: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. beta-galactosidase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10351035Beta-galactosidaseUniRule annotationPRO_0000367006Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi357804.Ping_2019.

Structurei

3D structure databases

ProteinModelPortaliA1SWB8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni540 – 5434Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000252443.
KOiK01190.
OMAiDPKKPYI.
OrthoDBiEOG6XWV0T.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPiMF_01687. Beta_gal.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1SWB8-1 [UniParc]FASTAAdd to Basket

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MREFSEIIKA RDWENQEVTH QHVVQAHAPL HAFHSKQAAL DNQASEFQQL     50
LNGQWRFQLF AKPEAVPNHC INIDFDDSAW SDITVPSNWQ LQGYDKPIYT 100
NVKYPFADNP PFVPADNPTG VYRLNFTLPT AWKERKNTVI FDGVNSAFHL 150
WCNGIWVGYS QDSRLPAEFD LSCHLQAGDN QLTVMVLRWS DGSYLEDQDM 200
WWLSGIFRDV CLLSKPLISI RDITVSTELD ACFNHGSINV VTQLSEQSSQ 250
YTAQVQLFDA QLQPVTKLVG APFGERMIDE KGPANDRAEH KIAVPSPHKW 300
SSESPYLYRV VISLVDNEGQ VVDSEAYQVG FRVVEMSNGQ LKLNGEALLI 350
RGVNRHEHHP EKGHAISYED MLVDIKLLKQ NNFNAVRTAH YPNHPLWYEL 400
CDQYGLYVVD EANLETHGQF PMSRLSNDLS WLNAYMRRMT RMVERDKNHP 450
SIIIWSLGNE SGLGHHHHAM YQWTKRRDPT RPVQYEGGGA DTAATDIIVP 500
MYARVNKDIT LPNAPDVVPK MAIKKWLSMP NEQRPLILCE YAHAMGNSLG 550
SFDKYWQAFR EYPRLQGGFI WDWVDQGLTK IDDNGDNYWA YGGDFGDQIN 600
DRQFCINGLV FPDRSLHPTV YEAKKAQQFY QFSLVDGDQL KVKIDSENLF 650
IESMDETLCW SVTEAGYVIA SGEMELHVTA QSSKILTLLE SYPEQKIGCD 700
YFLNIEIVLN KDKPWATKGF VVATEQVALA SIAQLTNVPL IESGAPRLSE 750
DKNKITVAGT GSGAEFELEI DKQQGVISQW LVRGENKILQ GPKDNFFRAP 800
LDNDIGTSEA DCIDPNAWVT QWDTAGIANL VPHCIAIEAV TLARSVLVKV 850
EFGHYVENKL LISSHWQYTI NNQGEVQIDV NVNLAKSLSP LPRIGLELIL 900
PDSEKPVNWF GRGPHENYPD RILSAHIARH CCSIEEMHTP YIFPSENGLR 950
CDVKDAIVGD LTVSGDFHLA VSRYSQMNIA QAKHVNDLIN DHQLYVRLDA 1000
FHMGVGGDDS WSPSVHDEFL LNKEHYHYQM ILAFN 1035
Length:1,035
Mass (Da):117,460
Last modified:February 6, 2007 - v1
Checksum:iEFBFDF2F17314885
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000510 Genomic DNA. Translation: ABM03783.1.
RefSeqiYP_943382.1. NC_008709.1.

Genome annotation databases

EnsemblBacteriaiABM03783; ABM03783; Ping_2019.
GeneIDi4624702.
KEGGipin:Ping_2019.
PATRICi23069241. VBIPsyIng103130_2222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000510 Genomic DNA. Translation: ABM03783.1 .
RefSeqi YP_943382.1. NC_008709.1.

3D structure databases

ProteinModelPortali A1SWB8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357804.Ping_2019.

Protein family/group databases

CAZyi GH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM03783 ; ABM03783 ; Ping_2019 .
GeneIDi 4624702.
KEGGi pin:Ping_2019.
PATRICi 23069241. VBIPsyIng103130_2222.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000252443.
KOi K01190.
OMAi DPKKPYI.
OrthoDBi EOG6XWV0T.

Enzyme and pathway databases

BioCyci PING357804:GJBJ-2105-MONOMER.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPi MF_01687. Beta_gal.
InterProi IPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
PRINTSi PR00132. GLHYDRLASE2.
SMARTi SM01038. Bgal_small_N. 1 hit.
[Graphical view ]
SUPFAMi SSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 37.

Entry informationi

Entry nameiBGAL_PSYIN
AccessioniPrimary (citable) accession number: A1SWB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi