A1SVW5 (TDH_PSYIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-threonine 3-dehydrogenase
EC=1.1.1.103

Gene names

Name:	tdh
Ordered Locus Names:	Ping_1853

Organism

Psychromonas ingrahamii (strain 37) [Complete proteome] [HAMAP]

Taxonomic identifier

357804 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Psychromonadaceae › Psychromonas

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH. HAMAP MF_00627
Cofactor	Binds 2 zinc ions per subunit By similarity. HAMAP MF_00627
Pathway	Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2. HAMAP MF_00627
Subunit structure	Homotetramer By similarity. HAMAP MF_00627
Subcellular location	Cytoplasm By similarity HAMAP MF_00627.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-threonine 3-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	L-threonine 3-dehydrogenase HAMAP MF_00627		PRO_1000051647
Sites
	Metal binding	40	1	Zinc 1; catalytic By similarity
	Metal binding	65	1	Zinc 1; catalytic By similarity
	Metal binding	95	1	Zinc 2 By similarity
	Metal binding	98	1	Zinc 2 By similarity
	Metal binding	101	1	Zinc 2 By similarity
	Metal binding	109	1	Zinc 2 By similarity
	Metal binding	150	1	Zinc 1; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1SVW5 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: FF035FE3358B8FA9	FASTA	344	37,405
	10 20 30 40 50 60 MKIKALAKLK PEVGIWMTTV DKPEPGHNDL LIKIHKTAIC GTDIHIYNWD EWSQNTIPVP 70 80 90 100 110 120 MVVGHEYVGE VVGMGQEVRG FSVGDRVSGE GHITCGHCRN CRAGRTHLCR NTIGVGVNRT 130 140 150 160 170 180 GAFAEYLVIP AFNAFKIPAG ISDDLASIFD PFGNAVHSAL SFDVVGEDVL ITGAGPIGIM 190 200 210 220 230 240 AAAVAKHAGA RYVVITDINE YRLDLARKMG VTRAVNVAQQ KLEDVIAQLG MTEGFDVGLE 250 260 270 280 290 300 MSGAPVAFNS MLKNMSHGGK IALLGIPPSD MSIDWNMVIF KGLVIKGIYG REMFETWYKM 310 320 330 340 ASLIQSGLDL DPIITHTFPV DKFQEGFDMM RSGKSGKVIL DWSI

References

[1]

"Complete sequence of Psychromonas ingrahamii 37." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Ivanova N., Staley J., Richardson P. Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 37.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000510 Genomic DNA. Translation: ABM03630.1.
RefSeq	YP_943229.1. NC_008709.1.
3D structure databases
ProteinModelPortal	A1SVW5.
ModBase	Search...
Protein-protein interaction databases
STRING	A1SVW5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4625040.
GenomeReviews	Gene locus Ping_1853 in contig CP000510_GR.
KEGG	pin:Ping_1853.
PATRIC	23068863. VBIPsyIng103130_2033.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1063.
HOGENOM	HBG753318.
OMA	NATHCAL.
PhylomeDB	A1SVW5.
ProtClustDB	PRK05396.
Enzyme and pathway databases
BioCyc	PING357804:PING_1853-MONOMER.
Family and domain databases
HAMAP	MF_00627. Thr_dehydrog. [Tree]
InterPro	IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR002328. ADH_Zn_CS. IPR011032. GroES-like. IPR004627. L-Threonine_3-DHase. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00060.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 1 hit.
TIGRFAMs	TIGR00692. Tdh. 1 hit.
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TDH_PSYIN

Accession

Primary (citable) accession number: A1SVW5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program