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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciPING357804:G1G7R-1832-MONOMER
UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:Ping_1730
OrganismiPsychromonas ingrahamii (strain 37)
Taxonomic identifieri357804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
Proteomesi
  • UP000000639 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002120871 – 406Nicotinate phosphoribosyltransferaseAdd BLAST406

Proteomic databases

PRIDEiA1SVJ9

Interactioni

Protein-protein interaction databases

STRINGi357804.Ping_1730

Structurei

3D structure databases

ProteinModelPortaliA1SVJ9
SMRiA1SVJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
HOGENOMiHOG000284928
KOiK00763
OMAiKLTMQCA
OrthoDBiPOG091H0197

Family and domain databases

HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

A1SVJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIKKLDYWL IESLMDTDLY KITMLQAYYH APEFRLVDIE WKFACRNRNG
60 70 80 90 100
LDLSILIPEI FRQLEHLCTL SFSDAELDYL AGFSFIKPDF IEFLRIFRLD
110 120 130 140 150
MRFVHIEAKG EDISLRFSGP LLHVSLLEIY TLAIISELHT FVNCGGIDLK
160 170 180 190 200
VARERLAEKI AYLKAEDDLS GFSFADFGTR RRASKAWHEE VLLTLKEQLP
210 220 230 240 250
ASFSGTSSLH FARTLGLPPI GTMAHEWFQS WQAVTRLADA QKAALEGWVQ
260 270 280 290 300
EYRGRLGIAL TDCYSMDSFI RDFSDPYFGK LYDGLRHDSG CPFVWAEKAI
310 320 330 340 350
LMYQQMGIDP LSKTLVFSDG LNFPRMLEIW KRFKGRAKIS FGIGTNLTND
360 370 380 390 400
VGNVPLNIVI KMIAANGRPI AKISDEPGKS MCEDLGYLQY LASQYGIDPS

LVKISQ
Length:406
Mass (Da):46,300
Last modified:February 6, 2007 - v1
Checksum:i8971D51D847D1303
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000510 Genomic DNA Translation: ABM03514.1
RefSeqiWP_011770074.1, NC_008709.1

Genome annotation databases

EnsemblBacteriaiABM03514; ABM03514; Ping_1730
KEGGipin:Ping_1730

Similar proteinsi

Entry informationi

Entry nameiPNCB_PSYIN
AccessioniPrimary (citable) accession number: A1SVJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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