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A1SU60

- SYL_PSYIN

UniProt

A1SU60 - SYL_PSYIN

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPING357804:GJBJ-1256-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Ping_1191
OrganismiPsychromonas ingrahamii (strain 37)
Taxonomic identifieri357804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
ProteomesiUP000000639: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Leucine--tRNA ligasePRO_1000009402Add
BLAST

Proteomic databases

PRIDEiA1SU60.

Interactioni

Protein-protein interaction databases

STRINGi357804.Ping_1191.

Structurei

3D structure databases

ProteinModelPortaliA1SU60.
SMRiA1SU60. Positions 228-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi618 – 6225"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1SU60-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQELYNPKEI EKKFQTNWDE NQSFKATEDP SKEKYYCLSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTIGD VISRYQRMQG KNVMQPMGWD AFGLPAENAA IKNNTAPAGW
110 120 130 140 150
TYENIAYMKT QLKQLGFGYD WSRELATCQP EYYRWEQWFF TKLVEKDLVY
160 170 180 190 200
KKMATVNWDP VDQTVLANEQ VIDGRGWRSG ALVEQKEIPQ WFIKITAYAQ
210 220 230 240 250
ELLDDLDKLD EWPEQVRTMQ RNWIGRSEGV EMDFKVSGKE ESFSVYTTRP
260 270 280 290 300
DTVMGVTYVA VAAQHPLALE AAKNNPTLAA FCKKCKNVKL AEAEIATMAK
310 320 330 340 350
EGVDTGFKAI HPISGLEVPI WTANFVLMGY GSGAVMSVPA HDQRDYEFAK
360 370 380 390 400
KYDLTIKAVI KPANTDLDIS VEAYTEKGVC FDSGEFDGLD FSAAFDAVET
410 420 430 440 450
KLVAENKGKR QVNFRLRDWG VSRQRYWGTP IPMLNLEDGS VVPVPENELP
460 470 480 490 500
VILPEDVQMN GIVSPIKADP DWAKTTYNGQ PATHETDTFD TFMESSWYYA
510 520 530 540 550
RYCSPQSDDA MLDPEKANYW LPVDQYIGGI EHAILHLLYS RFFHKLLRDF
560 570 580 590 600
GLVDCDEPYK KLLTQGMVLA DAYYYEDAKG GKVWIAPTDV ETETDEKGKV
610 620 630 640 650
ISAATKDGQT VIYDGMSKMS KSKNNGVDPQ VMIDKYGADS VRLFMMFAAP
660 670 680 690 700
ADQTLEWSDS ALEGSLRFLK RLWKIAFDHL ALGAVADLDL KSHTEAQKTL
710 720 730 740 750
RRELHKTIAK VTDDIGRRQT FNTAIASVME LMNKLTKTAT KTEQDRAILQ
760 770 780 790 800
EALLAITKLL APITPHICAE LFEVLGQTEE ILNAPWPTVD ESALVEDSKL
810 820 830 840 850
IVVQVNGKLR AKLTVAADAQ QETVQAIAME NENVSKFTDG KTIRKIIFVP

GKLLNIVAN
Length:859
Mass (Da):96,995
Last modified:February 6, 2007 - v1
Checksum:iB0636E5861FFDE2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000510 Genomic DNA. Translation: ABM03025.1.
RefSeqiWP_011769588.1. NC_008709.1.
YP_942624.1. NC_008709.1.

Genome annotation databases

EnsemblBacteriaiABM03025; ABM03025; Ping_1191.
GeneIDi4623588.
KEGGipin:Ping_1191.
PATRICi23067375. VBIPsyIng103130_1308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000510 Genomic DNA. Translation: ABM03025.1 .
RefSeqi WP_011769588.1. NC_008709.1.
YP_942624.1. NC_008709.1.

3D structure databases

ProteinModelPortali A1SU60.
SMRi A1SU60. Positions 228-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357804.Ping_1191.

Proteomic databases

PRIDEi A1SU60.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM03025 ; ABM03025 ; Ping_1191 .
GeneIDi 4623588.
KEGGi pin:Ping_1191.
PATRICi 23067375. VBIPsyIng103130_1308.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PING357804:GJBJ-1256-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 37.

Entry informationi

Entry nameiSYL_PSYIN
AccessioniPrimary (citable) accession number: A1SU60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3