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A1SU60

- SYL_PSYIN

UniProt

A1SU60 - SYL_PSYIN

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Protein
Leucine--tRNA ligase
Gene
leuS, Ping_1191
Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPING357804:GJBJ-1256-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Ping_1191
OrganismiPsychromonas ingrahamii (strain 37)
Taxonomic identifieri357804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
ProteomesiUP000000639: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Leucine--tRNA ligaseUniRule annotation
PRO_1000009402Add
BLAST

Proteomic databases

PRIDEiA1SU60.

Interactioni

Protein-protein interaction databases

STRINGi357804.Ping_1191.

Structurei

3D structure databases

ProteinModelPortaliA1SU60.
SMRiA1SU60. Positions 228-412.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi618 – 6225"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1SU60-1 [UniParc]FASTAAdd to Basket

« Hide

MQELYNPKEI EKKFQTNWDE NQSFKATEDP SKEKYYCLSM FPYPSGKLHM    50
GHVRNYTIGD VISRYQRMQG KNVMQPMGWD AFGLPAENAA IKNNTAPAGW 100
TYENIAYMKT QLKQLGFGYD WSRELATCQP EYYRWEQWFF TKLVEKDLVY 150
KKMATVNWDP VDQTVLANEQ VIDGRGWRSG ALVEQKEIPQ WFIKITAYAQ 200
ELLDDLDKLD EWPEQVRTMQ RNWIGRSEGV EMDFKVSGKE ESFSVYTTRP 250
DTVMGVTYVA VAAQHPLALE AAKNNPTLAA FCKKCKNVKL AEAEIATMAK 300
EGVDTGFKAI HPISGLEVPI WTANFVLMGY GSGAVMSVPA HDQRDYEFAK 350
KYDLTIKAVI KPANTDLDIS VEAYTEKGVC FDSGEFDGLD FSAAFDAVET 400
KLVAENKGKR QVNFRLRDWG VSRQRYWGTP IPMLNLEDGS VVPVPENELP 450
VILPEDVQMN GIVSPIKADP DWAKTTYNGQ PATHETDTFD TFMESSWYYA 500
RYCSPQSDDA MLDPEKANYW LPVDQYIGGI EHAILHLLYS RFFHKLLRDF 550
GLVDCDEPYK KLLTQGMVLA DAYYYEDAKG GKVWIAPTDV ETETDEKGKV 600
ISAATKDGQT VIYDGMSKMS KSKNNGVDPQ VMIDKYGADS VRLFMMFAAP 650
ADQTLEWSDS ALEGSLRFLK RLWKIAFDHL ALGAVADLDL KSHTEAQKTL 700
RRELHKTIAK VTDDIGRRQT FNTAIASVME LMNKLTKTAT KTEQDRAILQ 750
EALLAITKLL APITPHICAE LFEVLGQTEE ILNAPWPTVD ESALVEDSKL 800
IVVQVNGKLR AKLTVAADAQ QETVQAIAME NENVSKFTDG KTIRKIIFVP 850
GKLLNIVAN 859
Length:859
Mass (Da):96,995
Last modified:February 6, 2007 - v1
Checksum:iB0636E5861FFDE2E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000510 Genomic DNA. Translation: ABM03025.1.
RefSeqiYP_942624.1. NC_008709.1.

Genome annotation databases

EnsemblBacteriaiABM03025; ABM03025; Ping_1191.
GeneIDi4623588.
KEGGipin:Ping_1191.
PATRICi23067375. VBIPsyIng103130_1308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000510 Genomic DNA. Translation: ABM03025.1 .
RefSeqi YP_942624.1. NC_008709.1.

3D structure databases

ProteinModelPortali A1SU60.
SMRi A1SU60. Positions 228-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357804.Ping_1191.

Proteomic databases

PRIDEi A1SU60.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM03025 ; ABM03025 ; Ping_1191 .
GeneIDi 4623588.
KEGGi pin:Ping_1191.
PATRICi 23067375. VBIPsyIng103130_1308.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PING357804:GJBJ-1256-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 37.

Entry informationi

Entry nameiSYL_PSYIN
AccessioniPrimary (citable) accession number: A1SU60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi