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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Ping_1144
OrganismiPsychromonas ingrahamii (strain 37)
Taxonomic identifieri357804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
Proteomesi
  • UP000000639 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalUniRule annotationAdd BLAST21
Transmembranei71 – 91HelicalUniRule annotationAdd BLAST21
Transmembranei98 – 118HelicalUniRule annotationAdd BLAST21
Transmembranei142 – 162HelicalUniRule annotationAdd BLAST21
Transmembranei168 – 188HelicalUniRule annotationAdd BLAST21
Transmembranei199 – 219HelicalUniRule annotationAdd BLAST21
Transmembranei236 – 256HelicalUniRule annotationAdd BLAST21
Transmembranei263 – 283HelicalUniRule annotationAdd BLAST21
Transmembranei288 – 308HelicalUniRule annotationAdd BLAST21
Transmembranei338 – 358HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000030341 – 360Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST360

Proteomic databases

PRIDEiA1SU16.

Interactioni

Protein-protein interaction databases

STRINGi357804.Ping_1144.

Structurei

3D structure databases

SMRiA1SU16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A1SU16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVWLAELLS SQFTFLNVLT YLSVRTVMAV LTALAFSLFF GPKLIRFLQK
60 70 80 90 100
FQIGQIVRQD GPESHFSKAG TPTMGGILIL GAITFSSLLW ARLDNSYVWI
110 120 130 140 150
VLFTTLAFGA IGFMDDYLKV VRKHPDGLIA RWKYFWQSVT ALVLAVVLFL
160 170 180 190 200
SATTPAELTF VMPFFKQYMP YLGLAFIPLV YFTVVGSSNA VNLTDGLDGL
210 220 230 240 250
AIMPTVMVAA AFALIAYLTS HVNYAHYLYI PYIPKASELV VICGTIVGAG
260 270 280 290 300
LGFLWFNTYP AQVFMGDVGS LALGALLGVI AVLVRQEILL VIMGGIFVVE
310 320 330 340 350
TLSVILQVGS YKMRKRRIFR MAPIHHHYEK KGWPEPRVIV RFWIITIVLV
360
LIGLVTLKVR
Length:360
Mass (Da):40,117
Last modified:February 6, 2007 - v1
Checksum:iCB6A6B8D28700611
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000510 Genomic DNA. Translation: ABM02981.1.
RefSeqiWP_011769544.1. NC_008709.1.

Genome annotation databases

EnsemblBacteriaiABM02981; ABM02981; Ping_1144.
KEGGipin:Ping_1144.

Similar proteinsi

Entry informationi

Entry nameiMRAY_PSYIN
AccessioniPrimary (citable) accession number: A1SU16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: June 7, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families