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A1STK8

- A1STK8_PSYIN

UniProt

A1STK8 - A1STK8_PSYIN

Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Ping_0983

Organism
Psychromonas ingrahamii (strain 37)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei147 – 1471SubstrateUniRule annotation
    Sitei257 – 2571Critical for catalysisUniRule annotation
    Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
    Sitei422 – 4221Critical for catalysisUniRule annotation
    Binding sitei549 – 5491SubstrateUniRule annotation
    Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation
    Metal bindingi554 – 5541Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciPING357804:GJBJ-1046-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
    Gene namesi
    Ordered Locus Names:Ping_0983Imported
    OrganismiPsychromonas ingrahamii (strain 37)Imported
    Taxonomic identifieri357804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
    ProteomesiUP000000639: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535 PotentialImportedAdd
    BLAST
    Chaini36 – 742707 PotentialImportedPRO_5000206594Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi357804.Ping_0983.

    Structurei

    3D structure databases

    ProteinModelPortaliA1STK8.
    SMRiA1STK8. Positions 5-742.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1418Substrate bindingUniRule annotation

    Keywords - Domaini

    SignalImported

    Phylogenomic databases

    eggNOGiCOG2838.
    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiRPSEVFN.
    OrthoDBiEOG6DVJPP.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1STK8-1 [UniParc]FASTAAdd to Basket

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    MTDKSAKIIY TQTDEAPALA TYSLLPIVSA FTQAADITVE TRDISLAARI    50
    LATFPDNLSA EQKQADALTE LGELAQQPQA NIIKLPNVSA SVPQLHAAIK 100
    ELQSHGFDIP NYPEDPKTEA EKEAKARYAK VLGSAVNPVL REGNSDRRVA 150
    DAVKQYAQDH PHRMGAWSKE SKSHVADMSE GDFYGSEQSV VLKEADDVKI 200
    EFTSTSGAVS VLKASTPVLK DEVIDASVMS CSALRDFYET QMQDAKENNI 250
    MLSLHLKATM MKVSDPVMFG HAVTVYFKDV FAKHAVLFAE LGVDPRNGLG 300
    DVYSKIANLP AEQKEQIEAD IQEAYATGPA LAMVDSDKGI SNLHVPSDVI 350
    IDASMPAAIR TSGCMWGLDG KLHDTKAMIP DRCYSGIYQE TISFCREHGA 400
    FDPATMGNVS NVGLMAQKAE EYGSHDKTFI IKEAGSVKVI DQAGNTLMEH 450
    AVEEGDIWRM CQAKDIPIQD WVRLAVSRAR ATGQPAIFWL DEKRAHDGNL 500
    ITKVNHYLKD HDTDGLDISI LSPIDAIKIT LQRVSEGKNT ISVTGNVLRD 550
    YLTDLFPILE LGTSAKMLSI VPLLAGGGLF ETGAGGSAPK HVQQFIEEGH 600
    LRWDSIGEFL AIAVSIEDMA EKTGNKKALV LAETLHVANG KFLKEDRSPS 650
    RKVKEIDNRG SHFYLAMYWA EALAAQSKDT ELQAKFAPLA KVLTDNEEKI 700
    LAELAAAQGT PVDLGGYFHT DPVKMAAAMR PSTILNAALA TL 742
    Length:742
    Mass (Da):80,725
    Last modified:February 6, 2007 - v1
    Checksum:i01A0A0DE0A6EA2AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000510 Genomic DNA. Translation: ABM02823.1.
    RefSeqiYP_942422.1. NC_008709.1.

    Genome annotation databases

    EnsemblBacteriaiABM02823; ABM02823; Ping_0983.
    GeneIDi4626572.
    KEGGipin:Ping_0983.
    PATRICi23066921. VBIPsyIng103130_1082.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000510 Genomic DNA. Translation: ABM02823.1 .
    RefSeqi YP_942422.1. NC_008709.1.

    3D structure databases

    ProteinModelPortali A1STK8.
    SMRi A1STK8. Positions 5-742.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357804.Ping_0983.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM02823 ; ABM02823 ; Ping_0983 .
    GeneIDi 4626572.
    KEGGi pin:Ping_0983.
    PATRICi 23066921. VBIPsyIng103130_1082.

    Phylogenomic databases

    eggNOGi COG2838.
    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi RPSEVFN.
    OrthoDBi EOG6DVJPP.

    Enzyme and pathway databases

    BioCyci PING357804:GJBJ-1046-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 37Imported.

    Entry informationi

    Entry nameiA1STK8_PSYIN
    AccessioniPrimary (citable) accession number: A1STK8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3