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A1STK8

- A1STK8_PSYIN

UniProt

A1STK8 - A1STK8_PSYIN

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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Ping_0983

Organism
Psychromonas ingrahamii (strain 37)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei549 – 5491SubstrateUniRule annotation
Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation
Metal bindingi554 – 5541Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciPING357804:GJBJ-1046-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Ping_0983Imported
OrganismiPsychromonas ingrahamii (strain 37)Imported
Taxonomic identifieri357804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
ProteomesiUP000000639: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 PotentialImportedAdd
BLAST
Chaini36 – 742707 PotentialImportedPRO_5000206594Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi357804.Ping_0983.

Structurei

3D structure databases

ProteinModelPortaliA1STK8.
SMRiA1STK8. Positions 5-742.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiRPSEVFN.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1STK8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDKSAKIIY TQTDEAPALA TYSLLPIVSA FTQAADITVE TRDISLAARI
60 70 80 90 100
LATFPDNLSA EQKQADALTE LGELAQQPQA NIIKLPNVSA SVPQLHAAIK
110 120 130 140 150
ELQSHGFDIP NYPEDPKTEA EKEAKARYAK VLGSAVNPVL REGNSDRRVA
160 170 180 190 200
DAVKQYAQDH PHRMGAWSKE SKSHVADMSE GDFYGSEQSV VLKEADDVKI
210 220 230 240 250
EFTSTSGAVS VLKASTPVLK DEVIDASVMS CSALRDFYET QMQDAKENNI
260 270 280 290 300
MLSLHLKATM MKVSDPVMFG HAVTVYFKDV FAKHAVLFAE LGVDPRNGLG
310 320 330 340 350
DVYSKIANLP AEQKEQIEAD IQEAYATGPA LAMVDSDKGI SNLHVPSDVI
360 370 380 390 400
IDASMPAAIR TSGCMWGLDG KLHDTKAMIP DRCYSGIYQE TISFCREHGA
410 420 430 440 450
FDPATMGNVS NVGLMAQKAE EYGSHDKTFI IKEAGSVKVI DQAGNTLMEH
460 470 480 490 500
AVEEGDIWRM CQAKDIPIQD WVRLAVSRAR ATGQPAIFWL DEKRAHDGNL
510 520 530 540 550
ITKVNHYLKD HDTDGLDISI LSPIDAIKIT LQRVSEGKNT ISVTGNVLRD
560 570 580 590 600
YLTDLFPILE LGTSAKMLSI VPLLAGGGLF ETGAGGSAPK HVQQFIEEGH
610 620 630 640 650
LRWDSIGEFL AIAVSIEDMA EKTGNKKALV LAETLHVANG KFLKEDRSPS
660 670 680 690 700
RKVKEIDNRG SHFYLAMYWA EALAAQSKDT ELQAKFAPLA KVLTDNEEKI
710 720 730 740
LAELAAAQGT PVDLGGYFHT DPVKMAAAMR PSTILNAALA TL
Length:742
Mass (Da):80,725
Last modified:February 6, 2007 - v1
Checksum:i01A0A0DE0A6EA2AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000510 Genomic DNA. Translation: ABM02823.1.
RefSeqiYP_942422.1. NC_008709.1.

Genome annotation databases

EnsemblBacteriaiABM02823; ABM02823; Ping_0983.
GeneIDi4626572.
KEGGipin:Ping_0983.
PATRICi23066921. VBIPsyIng103130_1082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000510 Genomic DNA. Translation: ABM02823.1 .
RefSeqi YP_942422.1. NC_008709.1.

3D structure databases

ProteinModelPortali A1STK8.
SMRi A1STK8. Positions 5-742.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357804.Ping_0983.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM02823 ; ABM02823 ; Ping_0983 .
GeneIDi 4626572.
KEGGi pin:Ping_0983.
PATRICi 23066921. VBIPsyIng103130_1082.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi RPSEVFN.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci PING357804:GJBJ-1046-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 37Imported.

Entry informationi

Entry nameiA1STK8_PSYIN
AccessioniPrimary (citable) accession number: A1STK8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: November 26, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3