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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei151May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Ping_0923
OrganismiPsychromonas ingrahamii (strain 37)
Taxonomic identifieri357804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
Proteomesi
  • UP000000639 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002895131 – 304GTP cyclohydrolase FolE2Add BLAST304

Interactioni

Protein-protein interaction databases

STRINGi357804.Ping_0923.

Structurei

3D structure databases

SMRiA1STF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA. Bacteria.
COG1469. LUCA.
HOGENOMiHOG000247517.
KOiK09007.
OrthoDBiPOG091H0MIO.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B. 1 hit.
InterProiView protein in InterPro
IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
PANTHERiPTHR36445:SF2. PTHR36445:SF2. 1 hit.
PfamiView protein in Pfam
PF02649. GCHY-1. 1 hit.

Sequencei

Sequence statusi: Complete.

A1STF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDIANSAQA QTEGKLDRVG MSNIELPLMV QTDDCPPQQV SANAEVFVNL
60 70 80 90 100
GDAQAKGIHM SRLYLQLDEL STESELNIST LTALLQGFIT SHHELSQRAF
110 120 130 140 150
VKFSFDYHLR RKSLISEKRG WKAYPVIIIG RLSEGNFEVE LQVNVPYSST
160 170 180 190 200
CPCSAALARQ LIQQAFSQKY DQQTEVNKEE IFAWLGSTKG IVATPHSQRS
210 220 230 240 250
IVEVKVKLNS LNQSFPIIEL IDLIEKTLKT PVQAAVKRED EQEFALLNGQ
260 270 280 290 300
NLMFCEDAAR HLQHSLHQET KFDDFWLRVN HYESLHAHDA VAMTTKGIEG

GYLA
Length:304
Mass (Da):34,214
Last modified:May 5, 2009 - v2
Checksum:i7BEC562D962AA553
GO

Sequence cautioni

The sequence ABM02765 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000510 Genomic DNA. Translation: ABM02765.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiABM02765; ABM02765; Ping_0923.
KEGGipin:Ping_0923.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGCH4_PSYIN
AccessioniPrimary (citable) accession number: A1STF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 5, 2009
Last modified: July 5, 2017
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families