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A1STF0

- GCH4_PSYIN

UniProt

A1STF0 - GCH4_PSYIN

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei151 – 1511May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciPING357804:GJBJ-971-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Ping_0923
    OrganismiPsychromonas ingrahamii (strain 37)
    Taxonomic identifieri357804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
    ProteomesiUP000000639: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 304304GTP cyclohydrolase FolE2PRO_0000289513Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi357804.Ping_0923.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1STF0-1 [UniParc]FASTAAdd to Basket

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    MPDIANSAQA QTEGKLDRVG MSNIELPLMV QTDDCPPQQV SANAEVFVNL    50
    GDAQAKGIHM SRLYLQLDEL STESELNIST LTALLQGFIT SHHELSQRAF 100
    VKFSFDYHLR RKSLISEKRG WKAYPVIIIG RLSEGNFEVE LQVNVPYSST 150
    CPCSAALARQ LIQQAFSQKY DQQTEVNKEE IFAWLGSTKG IVATPHSQRS 200
    IVEVKVKLNS LNQSFPIIEL IDLIEKTLKT PVQAAVKRED EQEFALLNGQ 250
    NLMFCEDAAR HLQHSLHQET KFDDFWLRVN HYESLHAHDA VAMTTKGIEG 300
    GYLA 304
    Length:304
    Mass (Da):34,214
    Last modified:May 5, 2009 - v2
    Checksum:i7BEC562D962AA553
    GO

    Sequence cautioni

    The sequence ABM02765.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000510 Genomic DNA. Translation: ABM02765.1. Different initiation.
    RefSeqiYP_942364.1. NC_008709.1.

    Genome annotation databases

    EnsemblBacteriaiABM02765; ABM02765; Ping_0923.
    GeneIDi4623578.
    KEGGipin:Ping_0923.
    PATRICi23066757. VBIPsyIng103130_1015.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000510 Genomic DNA. Translation: ABM02765.1 . Different initiation.
    RefSeqi YP_942364.1. NC_008709.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357804.Ping_0923.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM02765 ; ABM02765 ; Ping_0923 .
    GeneIDi 4623578.
    KEGGi pin:Ping_0923.
    PATRICi 23066757. VBIPsyIng103130_1015.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci PING357804:GJBJ-971-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 37.

    Entry informationi

    Entry nameiGCH4_PSYIN
    AccessioniPrimary (citable) accession number: A1STF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 47 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3