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A1SSC6 (MAO1_PSYIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NAD-dependent malic enzyme
Short name=NAD-ME
EC=1.1.1.38
Gene names
Name:maeA
Ordered Locus Names:Ping_0537
OrganismPsychromonas ingrahamii (strain 37) [Complete proteome] [HAMAP]
Taxonomic identifier357804 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Psychromonadaceae › Psychromonas

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-malate + NAD+ = pyruvate + CO2 + NADH. HAMAP MF_01619

Cofactor

Divalent metal cations. Prefers magnesium or manganese By similarity.

Subunit structure

Homotetramer By similarity. HAMAP MF_01619

Sequence similarities

Belongs to the malic enzymes family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 560560NAD-dependent malic enzyme HAMAP MF_01619
PRO_1000069536

Sites

Active site1001Proton donor By similarity
Active site1711Proton acceptor By similarity
Metal binding2421Divalent metal cation By similarity
Metal binding2431Divalent metal cation By similarity
Metal binding2661Divalent metal cation By similarity
Binding site1531NAD By similarity
Binding site2661NAD By similarity
Binding site4131NAD By similarity
Site2661Important for activity By similarity

Sequences

Sequence LengthMass (Da)Tools
A1SSC6 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: CAE729D46EA5CA06

FASTA56062,299
        10         20         30         40         50         60 
MTFQRPLYIP FAGPALLESP LLNKGSAFSQ EERNNFNLTG LLPHNIETIE SQSTRAYQQL 

        70         80         90        100        110        120 
SSFKSDLDKH IYLRNIQDTN ETLFHHLIEN HLEEVMPLIY TPTVGLACEQ FSKIYRRKRG 

       130        140        150        160        170        180 
LFVSYPERHK IDDMLQNATK QNVKVIVVTD GERILGLGDQ GIGGMGIPIG KLALYTACGG 

       190        200        210        220        230        240 
ISPAYCLPIV LDVGTNNSQL LADPMYMGWR NPRITGEEYN EFVDLFIQAV KRRWPEVLLQ 

       250        260        270        280        290        300 
FEDFAQTNAT PLLNKYRDQI CCFNDDIQGT AAVSVGTLIA ACQNKGEKLS DQRIAFLGSG 

       310        320        330        340        350        360 
SAGCGIAQHI VRQMQREGLT QEQARQRVFM VDRYGLLTDQ MTNLQAFQQP LIQYTKDLSH 

       370        380        390        400        410        420 
WDISSHIGLE QVIKQGNISV LFGVSGQPGL FTQEVVESLC ANVDHPIVLP LSNPTSRVEA 

       430        440        450        460        470        480 
TPKDITTWSH GQAIVATGSP FPPTLYENEY IEVSQCNNSY IFPGIGLGVL AARATAISDN 

       490        500        510        520        530        540 
MLMAASQALA DASMQYEKVK GALLPPLGEI RPISKSIAYA VAKQAIADGL ALPVSEETMQ 

       550        560 
RRLVDNFWAP KYRTYRRTSF

« Hide

References

[1]"Complete sequence of Psychromonas ingrahamii 37."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Ivanova N., Staley J., Richardson P.
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 37.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000510 Genomic DNA. Translation: ABM02391.1.
RefSeqYP_941990.1. NC_008709.1.

3D structure databases

ProteinModelPortalA1SSC6.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1SSC6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4623724.
GenomeReviewsGene locus Ping_0537 in contig CP000510_GR.
KEGGpin:Ping_0537.
PATRIC23065877. VBIPsyIng103130_0591.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0281.
HOGENOMHBG289821.
OMAQDNNETL.
PhylomeDBA1SSC6.
ProtClustDBPRK13529.

Enzyme and pathway databases

BioCycPING357804:PING_0537-MONOMER.

Family and domain databases

HAMAPMF_01619. NAD_malic_enz.
[Tree]
InterProIPR015884. Malic_enzyme_CS.
IPR012301. Malic_N.
IPR012302. Malic_NAD-bd.
IPR001891. Malic_OxRdtase.
IPR016040. NAD(P)-bd_dom.
IPR023667. NAD_malic_enz_proteobac.
[Graphical view]
Gene3DG3DSA:3.40.50.10380. G3DSA:3.40.50.10380. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00027.
PfamPF00390. malic. 1 hit.
PF03949. Malic_M. 1 hit.
[Graphical view]
PIRSFPIRSF000106. ME. 1 hit.
PRINTSPR00072. MALOXRDTASE.
SMARTSM00919. Malic_M. 1 hit.
[Graphical view]
PROSITEPS00331. MALIC_ENZYMES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMAO1_PSYIN
AccessionPrimary (citable) accession number: A1SSC6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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