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Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.

Cofactori

a divalent metal cation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolase (EC:3.6.1.-)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolase
Gene namesi
Name:rppH
Synonyms:nudH
Ordered Locus Names:Ping_0502
OrganismiPsychromonas ingrahamii (strain 37)
Taxonomic identifieri357804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
Proteomesi
  • UP000000639 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000219771 – 181RNA pyrophosphohydrolaseAdd BLAST181

Interactioni

Protein-protein interaction databases

STRINGi357804.Ping_0502.

Structurei

3D structure databases

ProteinModelPortaliA1SS92.
SMRiA1SS92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 150Nudix hydrolaseAdd BLAST145

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 59Nudix boxAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.

Phylogenomic databases

eggNOGiENOG4105EJF. Bacteria.
COG0494. LUCA.
HOGENOMiHOG000066723.
KOiK08311.
OMAiRPCVGIM.
OrthoDBiPOG091H0392.

Family and domain databases

CDDicd03671. Ap4A_hydrolase_plant_like. 1 hit.
HAMAPiMF_00298. Nudix_RppH. 1 hit.
InterProiView protein in InterPro
IPR020476. Nudix_hydrolase.
IPR015797. NUDIX_hydrolase-like_dom_sf.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR022927. RppH.
PfamiView protein in Pfam
PF00293. NUDIX. 1 hit.
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiView protein in PROSITE
PS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.

Sequencei

Sequence statusi: Complete.

A1SS92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDTDGYRPN VGIIICNNNA QVLWAKRFGQ HSWQFPQGGI KEGETPEQAM
60 70 80 90 100
YRELYEEVGL KPEHVKLLAT SRHWLRYKLP KRLVRWDSPD PVCIGQKQRW
110 120 130 140 150
FLLQLISDEQ QIEFEACGNP EFDAWRWVTY WYPVRQVVSF KCEVYRCALK
160 170 180
EFSAVAFSLM KKSSDKKRNK RPRRASFYKK R
Length:181
Mass (Da):21,623
Last modified:February 6, 2007 - v1
Checksum:iBDB9BFE2181F8182
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000510 Genomic DNA. Translation: ABM02357.1.
RefSeqiWP_011768916.1. NC_008709.1.

Genome annotation databases

EnsemblBacteriaiABM02357; ABM02357; Ping_0502.
KEGGipin:Ping_0502.

Similar proteinsi

Entry informationi

Entry nameiRPPH_PSYIN
AccessioniPrimary (citable) accession number: A1SS92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: November 22, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families