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A1SRX3

- TRMB_PSYIN

UniProt

A1SRX3 - TRMB_PSYIN

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei74 – 741S-adenosyl-L-methionineUniRule annotation
    Binding sitei99 – 991S-adenosyl-L-methionineUniRule annotation
    Binding sitei126 – 1261S-adenosyl-L-methionineUniRule annotation
    Active sitei149 – 1491By similarity
    Binding sitei149 – 1491S-adenosyl-L-methionineUniRule annotation
    Binding sitei153 – 1531SubstrateUniRule annotation
    Binding sitei185 – 1851SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciPING357804:GJBJ-400-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:Ping_0377
    OrganismiPsychromonas ingrahamii (strain 37)
    Taxonomic identifieri357804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
    ProteomesiUP000000639: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 243243tRNA (guanine-N(7)-)-methyltransferasePRO_0000288206Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi357804.Ping_0377.

    Structurei

    3D structure databases

    ProteinModelPortaliA1SRX3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni221 – 2244Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiHSTLEMA.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1SRX3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDQEHSASE ENADSVEKHK YMRKIRSFVK REGRMTNRQQ TAIDTLWDTM    50
    GIDFEEKLID FNALFGRQAP IVLEIGFGMG KSLIEMAKNA PEKNFIGIEV 100
    HGPGVGACLA DAGEAGVTNL RVINHDAVEV LDKMIPDNSL AVFQLYFPDP 150
    WHKARHHKRR IVQPHFIENM RHKLAIGGVI HMATDWENYA EHMLAVLQAS 200
    PDFKNTSESD YAPRPEWRPL TKFENRGNNL GHGVWDLLFE RIS 243
    Length:243
    Mass (Da):27,732
    Last modified:February 6, 2007 - v1
    Checksum:i54D4D71429C1CA02
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000510 Genomic DNA. Translation: ABM02238.1.
    RefSeqiYP_941837.1. NC_008709.1.

    Genome annotation databases

    EnsemblBacteriaiABM02238; ABM02238; Ping_0377.
    GeneIDi4624183.
    KEGGipin:Ping_0377.
    PATRICi23065500. VBIPsyIng103130_0410.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000510 Genomic DNA. Translation: ABM02238.1 .
    RefSeqi YP_941837.1. NC_008709.1.

    3D structure databases

    ProteinModelPortali A1SRX3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357804.Ping_0377.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM02238 ; ABM02238 ; Ping_0377 .
    GeneIDi 4624183.
    KEGGi pin:Ping_0377.
    PATRICi 23065500. VBIPsyIng103130_0410.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi HSTLEMA.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci PING357804:GJBJ-400-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 37.

    Entry informationi

    Entry nameiTRMB_PSYIN
    AccessioniPrimary (citable) accession number: A1SRX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3