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A1SRI3

- ASSY_PSYIN

UniProt

A1SRI3 - ASSY_PSYIN

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Protein
Argininosuccinate synthase
Gene
argG, Ping_0231
Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei90 – 901Citrulline By similarity
Binding sitei120 – 1201ATP; via amide nitrogen By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei126 – 1261Aspartate By similarity
Binding sitei126 – 1261Citrulline By similarity
Binding sitei127 – 1271Aspartate By similarity
Binding sitei130 – 1301Citrulline By similarity
Binding sitei179 – 1791Citrulline By similarity
Binding sitei188 – 1881Citrulline By similarity
Binding sitei264 – 2641Citrulline By similarity
Binding sitei276 – 2761Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPING357804:GJBJ-243-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Ping_0231
OrganismiPsychromonas ingrahamii (strain 37)
Taxonomic identifieri357804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
ProteomesiUP000000639: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Argininosuccinate synthaseUniRule annotation
PRO_0000321317Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi357804.Ping_0231.

Structurei

3D structure databases

ProteinModelPortaliA1SRI3.
SMRiA1SRI3. Positions 6-399.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiPWNEPTK.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1SRI3-1 [UniParc]FASTAAdd to Basket

« Hide

MSKVKKVVLA YSGGLDTSAI IPWLKETYDD CEIIAFCADV GQGAEELVGL    50
EEKALASGAS ECHIVDLKEE FVKDYIYPTM ASGAVYEGTY LLGTAMARPI 100
IAKAQVEVAL KVGADALCHG CTGKGNDQIR FESCFAALAP ELQVIAPWRE 150
WEMESREDLL DYLAERNIET TASATKIYSR DANAWHISHE GGELENPWNA 200
PSKGVWTLTV DPEDAPDKPE YLTIKVENAR VVAVDGVELS PYDALMLLNE 250
KAAAHGVGRV DITENRTVGM KSRGCYETPG GTVMVAALRG IDELVHDKPA 300
RKWRDQVGQE FTHLVYDGRW FTPLCGSLLA ASEALAKDVN GEVVVKMYKG 350
QVTAEQKRSP NSLYSEEFAT FGDDNVYNQK HAEGFIRLYS LSSRIRTLNS 400
KK 402
Length:402
Mass (Da):44,241
Last modified:February 6, 2007 - v1
Checksum:i2F8C6406E27464AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000510 Genomic DNA. Translation: ABM02098.1.
RefSeqiYP_941697.1. NC_008709.1.

Genome annotation databases

EnsemblBacteriaiABM02098; ABM02098; Ping_0231.
GeneIDi4625791.
KEGGipin:Ping_0231.
PATRICi23065158. VBIPsyIng103130_0250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000510 Genomic DNA. Translation: ABM02098.1 .
RefSeqi YP_941697.1. NC_008709.1.

3D structure databases

ProteinModelPortali A1SRI3.
SMRi A1SRI3. Positions 6-399.
ModBasei Search...

Protein-protein interaction databases

STRINGi 357804.Ping_0231.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM02098 ; ABM02098 ; Ping_0231 .
GeneIDi 4625791.
KEGGi pin:Ping_0231.
PATRICi 23065158. VBIPsyIng103130_0250.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi PWNEPTK.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci PING357804:GJBJ-243-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 37.

Entry informationi

Entry nameiASSY_PSYIN
AccessioniPrimary (citable) accession number: A1SRI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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