A1SR30 (AROE_PSYIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Ping_0071

Organism

Psychromonas ingrahamii (strain 37) [Complete proteome] [HAMAP]

Taxonomic identifier

357804 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Psychromonadaceae › Psychromonas

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000021319
Regions
	Nucleotide binding	126 – 130	5	NADP By similarity
Sites
	Active site	65	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	A1SR30 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 56E79FE707E22B29	FASTA	272	29,480
	10 20 30 40 50 60 MDNYAVFGNP IKQSKSPFIH TLFAQQTQEK IVYSAIEPAT DDFKTALKDF FLEQGKGCNI 70 80 90 100 110 120 TAPFKEQAYQ YAQQLTERAA LAGAVNTLKL TDDGIIIGDN TDGAGLVLDL KNNNVTLKGS 130 140 150 160 170 180 RILLIGAGGA ARGVCGPLLA EHPKELIIAN RTFSKAQTLT TIFTKLGNIS ACEFSELSGE 190 200 210 220 230 240 FDLIINSTSA SLHGEVPLIG TKLIRPETTI YDMMYSAQVT PFNAWAKEQG AKFILDGLGM 250 260 270 LVGQAAESFA IWRGVKPDAK QVLNELRHHL AT

References

[1]

"Complete sequence of Psychromonas ingrahamii 37." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Ivanova N., Staley J., Richardson P. Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 37.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000510 Genomic DNA. Translation: ABM01945.1.
RefSeq	YP_941544.1. NC_008709.1.
3D structure databases
ProteinModelPortal	A1SR30.
SMR	A1SR30. Positions 1-271.
ModBase	Search...
Protein-protein interaction databases
STRING	A1SR30.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4626625.
GenomeReviews	Gene locus Ping_0071 in contig CP000510_GR.
KEGG	pin:Ping_0071.
PATRIC	23064810. VBIPsyIng103130_0079.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	VVFGNPI.
PhylomeDB	A1SR30.
ProtClustDB	PRK00258.
Enzyme and pathway databases
BioCyc	PING357804:PING_0071-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_PSYIN

Accession

Primary (citable) accession number: A1SR30

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program