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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Psychromonas ingrahamii (strain 37)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium or manganese ions per subunit.UniRule annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi312Magnesium or manganese 1UniRule annotation1
Metal bindingi324Magnesium or manganese 1UniRule annotation1
Metal bindingi324Magnesium or manganese 2UniRule annotation1
Metal bindingi326Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:Ping_0036Imported
OrganismiPsychromonas ingrahamii (strain 37)Imported
Taxonomic identifieri357804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
Proteomesi
  • UP000000639 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi357804.Ping_0036.

Structurei

3D structure databases

ProteinModelPortaliA1SQZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini150 – 357ATP-graspInterPro annotationAdd BLAST208

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CPF. Bacteria.
COG1181. LUCA.
HOGENOMiHOG000011593.
KOiK01921.
OMAiRTAKWIT.
OrthoDBiPOG091H06GK.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PIRSFiPIRSF039102. Ddl/VanB. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A1SQZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSRMKVAV VFGGKSTEHD VSIISAGHIL ANIDMEKYFV EPFYVKKDGT
60 70 80 90 100
FADHQELTLC LENLLNEHRD KIFPAMKEGE IELKKWIAKG TSSDFLGGIA
110 120 130 140 150
GKKFDIVFPV LHGLNGEDGT IQGMLEFMGV PYVGCGVSAS AFCIDKEATK
160 170 180 190 200
VICQVNDIPV MDYTAVKKYE WENSTENIIN DIQKKMNYPF YVKPARLGSS
210 220 230 240 250
IGISRAENTV ELKTSLKDAF KYDCKVVVEQ GVESPRELTV GVMGIDDQVS
260 270 280 290 300
LSAIGEFSRG SNLYFNFDSK YGKTGHKGLV PAPLEENIQE IIEKYSHLIF
310 320 330 340 350
KKFELSGFAR IDYFLCGDKV YLNEINTMPG FETGDTFMRI WQNKGVDMQK
360 370 380
FIDKAIEYGV LSFHSKSTRL YEIEIKSLIE
Length:380
Mass (Da):42,743
Last modified:February 6, 2007 - v1
Checksum:i4DF36236CE85ACCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000510 Genomic DNA. Translation: ABM01911.1.
RefSeqiWP_011768470.1. NC_008709.1.

Genome annotation databases

EnsemblBacteriaiABM01911; ABM01911; Ping_0036.
KEGGipin:Ping_0036.

Entry informationi

Entry nameiA1SQZ6_PSYIN
AccessioniPrimary (citable) accession number: A1SQZ6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 27, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported