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A1SQH3

- FTHS_NOCSJ

UniProt

A1SQH3 - FTHS_NOCSJ

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Nocardioides sp. (strain BAA-499 / JS614)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi66 – 738ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNSP196162:GH4V-4616-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Noca_4561
    OrganismiNocardioides sp. (strain BAA-499 / JS614)
    Taxonomic identifieri196162 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaeNocardioidaceaeNocardioides
    ProteomesiUP000000640: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000293049Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi196162.Noca_4561.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1SQH3-1 [UniParc]FASTAAdd to Basket

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    MLSDIEIAGA ATLRPITEVA TESLGIGAEH LVPYGHYKAK VGITYLNSLA    50
    DRPLGRLILV TALSPTPPGE GKTTTSVGLT DALHGLGKRA IACLREPSMG 100
    PVFGLKGGAA GGGYSQVVPM TDINLHFTGD FAAIAAANNL LAALIDNHVH 150
    HGNELDIDVR SVTWKRVLDT NDRALREVVV GLGGPPNGFP RQDGFDIVVA 200
    SELMAIFCLT ESWADLKRRI GDIVIGYSRA GAPVTARDLG ADGAMAVLLR 250
    DAIAPNLVQT LEGAPALVHG GPFANIAHGC SSVMATRAGL RLADYVVTEA 300
    GFGADLGAEK FIDIKCRMSG MRPDVAVVVA TVRALKYHGG VALADLDRED 350
    LGAVEAGMDN LRRHLDNLRH LNGVPCVVAV NRFPTDTDLE VVRVVELAAS 400
    YGVPAYQATH FTDGGIGAQD LAKGVLQALE EPARDEFSFT YPDELSLTEK 450
    VEAVATRVYG AGQVTWDGKA RKRLARIERD GYGTLPVCVA KTQYSFSTDP 500
    GLLGAPTGHE LRVREVRLSA GAGFVVVICG DMMTMPGLPT RPAATRIDLA 550
    DDGTIIGLS 559
    Length:559
    Mass (Da):58,921
    Last modified:February 6, 2007 - v1
    Checksum:i6CCE6AECED3646C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000509 Genomic DNA. Translation: ABL84058.1.
    RefSeqiWP_011757986.1. NC_008699.1.
    YP_925745.1. NC_008699.1.

    Genome annotation databases

    EnsemblBacteriaiABL84058; ABL84058; Noca_4561.
    GeneIDi4597080.
    KEGGinca:Noca_4561.
    PATRICi22751283. VBINocSp122728_4867.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000509 Genomic DNA. Translation: ABL84058.1 .
    RefSeqi WP_011757986.1. NC_008699.1.
    YP_925745.1. NC_008699.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196162.Noca_4561.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL84058 ; ABL84058 ; Noca_4561 .
    GeneIDi 4597080.
    KEGGi nca:Noca_4561.
    PATRICi 22751283. VBINocSp122728_4867.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci NSP196162:GH4V-4616-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Nocardioides sp. JS614."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.
      , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BAA-499 / JS614.

    Entry informationi

    Entry nameiFTHS_NOCSJ
    AccessioniPrimary (citable) accession number: A1SQH3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3