A1SQH3 (FTHS_NOCSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS

Gene names

Name:	fhs
Ordered Locus Names:	Noca_4561

Organism

Nocardioides sp. (strain BAA-499 / JS614) [Complete proteome] [HAMAP]

Taxonomic identifier

196162 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Nocardioidaceae › Nocardioides

Protein attributes

Sequence length	559 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 559	559	Formate--tetrahydrofolate ligase HAMAP MF_01543		PRO_0000293049
Regions
	Nucleotide binding	66 – 73	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1SQH3 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 6CCE6AECED3646C3	FASTA	559	58,921
	10 20 30 40 50 60 MLSDIEIAGA ATLRPITEVA TESLGIGAEH LVPYGHYKAK VGITYLNSLA DRPLGRLILV 70 80 90 100 110 120 TALSPTPPGE GKTTTSVGLT DALHGLGKRA IACLREPSMG PVFGLKGGAA GGGYSQVVPM 130 140 150 160 170 180 TDINLHFTGD FAAIAAANNL LAALIDNHVH HGNELDIDVR SVTWKRVLDT NDRALREVVV 190 200 210 220 230 240 GLGGPPNGFP RQDGFDIVVA SELMAIFCLT ESWADLKRRI GDIVIGYSRA GAPVTARDLG 250 260 270 280 290 300 ADGAMAVLLR DAIAPNLVQT LEGAPALVHG GPFANIAHGC SSVMATRAGL RLADYVVTEA 310 320 330 340 350 360 GFGADLGAEK FIDIKCRMSG MRPDVAVVVA TVRALKYHGG VALADLDRED LGAVEAGMDN 370 380 390 400 410 420 LRRHLDNLRH LNGVPCVVAV NRFPTDTDLE VVRVVELAAS YGVPAYQATH FTDGGIGAQD 430 440 450 460 470 480 LAKGVLQALE EPARDEFSFT YPDELSLTEK VEAVATRVYG AGQVTWDGKA RKRLARIERD 490 500 510 520 530 540 GYGTLPVCVA KTQYSFSTDP GLLGAPTGHE LRVREVRLSA GAGFVVVICG DMMTMPGLPT 550 RPAATRIDLA DDGTIIGLS

References

[1]

"Complete sequence of chromosome 1 of Nocardioides sp. JS614." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BAA-499 / JS614.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000509 Genomic DNA. Translation: ABL84058.1.
RefSeq	YP_925745.1. NC_008699.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1SQH3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4597080.
GenomeReviews	Gene locus Noca_4561 in contig CP000509_GR.
KEGG	nca:Noca_4561.
PATRIC	22751283. VBINocSp122728_4867.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
HOGENOM	HBG677721.
OMA	TDFTVTI.
PhylomeDB	A1SQH3.
Enzyme and pathway databases
BioCyc	NSP35761:NOCA_4561-MONOMER.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS_NOCSJ

Accession

Primary (citable) accession number: A1SQH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program