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A1SQH3

- FTHS_NOCSJ

UniProt

A1SQH3 - FTHS_NOCSJ

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Noca_4561
Organism
Nocardioides sp. (strain BAA-499 / JS614)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNSP196162:GH4V-4616-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Noca_4561
OrganismiNocardioides sp. (strain BAA-499 / JS614)
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaeNocardioidaceaeNocardioides
ProteomesiUP000000640: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000293049Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196162.Noca_4561.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1SQH3-1 [UniParc]FASTAAdd to Basket

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MLSDIEIAGA ATLRPITEVA TESLGIGAEH LVPYGHYKAK VGITYLNSLA    50
DRPLGRLILV TALSPTPPGE GKTTTSVGLT DALHGLGKRA IACLREPSMG 100
PVFGLKGGAA GGGYSQVVPM TDINLHFTGD FAAIAAANNL LAALIDNHVH 150
HGNELDIDVR SVTWKRVLDT NDRALREVVV GLGGPPNGFP RQDGFDIVVA 200
SELMAIFCLT ESWADLKRRI GDIVIGYSRA GAPVTARDLG ADGAMAVLLR 250
DAIAPNLVQT LEGAPALVHG GPFANIAHGC SSVMATRAGL RLADYVVTEA 300
GFGADLGAEK FIDIKCRMSG MRPDVAVVVA TVRALKYHGG VALADLDRED 350
LGAVEAGMDN LRRHLDNLRH LNGVPCVVAV NRFPTDTDLE VVRVVELAAS 400
YGVPAYQATH FTDGGIGAQD LAKGVLQALE EPARDEFSFT YPDELSLTEK 450
VEAVATRVYG AGQVTWDGKA RKRLARIERD GYGTLPVCVA KTQYSFSTDP 500
GLLGAPTGHE LRVREVRLSA GAGFVVVICG DMMTMPGLPT RPAATRIDLA 550
DDGTIIGLS 559
Length:559
Mass (Da):58,921
Last modified:February 6, 2007 - v1
Checksum:i6CCE6AECED3646C3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000509 Genomic DNA. Translation: ABL84058.1.
RefSeqiWP_011757986.1. NC_008699.1.
YP_925745.1. NC_008699.1.

Genome annotation databases

EnsemblBacteriaiABL84058; ABL84058; Noca_4561.
GeneIDi4597080.
KEGGinca:Noca_4561.
PATRICi22751283. VBINocSp122728_4867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000509 Genomic DNA. Translation: ABL84058.1 .
RefSeqi WP_011757986.1. NC_008699.1.
YP_925745.1. NC_008699.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196162.Noca_4561.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL84058 ; ABL84058 ; Noca_4561 .
GeneIDi 4597080.
KEGGi nca:Noca_4561.
PATRICi 22751283. VBINocSp122728_4867.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci NSP196162:GH4V-4616-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Nocardioides sp. JS614."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.
    , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BAA-499 / JS614.

Entry informationi

Entry nameiFTHS_NOCSJ
AccessioniPrimary (citable) accession number: A1SQH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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