Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Nocardioides sp. (strain ATCC BAA-499 / JS614)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei30Desacetylmycothiol; via amide nitrogenUniRule annotation1
Binding sitei165DesacetylmycothiolUniRule annotation1
Binding sitei209DesacetylmycothiolUniRule annotation1
Binding sitei227DesacetylmycothiolUniRule annotation1
Binding sitei265Desacetylmycothiol; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:Noca_4248
OrganismiNocardioides sp. (strain ATCC BAA-499 / JS614)
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesNocardioidaceaeNocardioides
Proteomesi
  • UP000000640 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004002861 – 295Mycothiol acetyltransferaseAdd BLAST295

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi196162.Noca_4248.

Structurei

3D structure databases

ProteinModelPortaliA1SPL0.
SMRiA1SPL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini137 – 295N-acetyltransferaseUniRule annotationAdd BLAST159

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 64Acetyl-CoA binding 1UniRule annotation3
Regioni231 – 233Acetyl-CoA binding 2UniRule annotation3
Regioni238 – 244Acetyl-CoA binding 2UniRule annotation7

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiAEPWFDP.
OrthoDBiPOG091H09IL.

Family and domain databases

HAMAPiMF_01698. MshD. 1 hit.
InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
PfamiView protein in Pfam
PF00583. Acetyltransf_1. 1 hit.
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiView protein in PROSITE
PS51186. GNAT. 1 hit.

Sequencei

Sequence statusi: Complete.

A1SPL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDHAADLLA AVAEVARAAE AADGAAPLDE ATWLALRHHP ERVRSWVRAG
60 70 80 90 100
GFALVIGADL SLVVHPQARG RGLGAGLLSS ALAGLSAGMP LEAWSHGDHP
110 120 130 140 150
AAAALARSHG FERARELWVM RRQMASALPQ LRAPDGVTVR AFRADSGDAE
160 170 180 190 200
EVLRVNAAAF AHHPEQGSMD ATNLAERMAE PWFDPDGLLL ATSAAADGGE
210 220 230 240 250
QVLGFHWTKV HPGDAGAGAG PGVEVGEVYV VGIDPAAQGR GLGKVLTLAG
260 270 280 290
LHHLAGRGVP EVLLYVESDN RPAIAVYAGL GFTHADDDTH VQYRR
Length:295
Mass (Da):30,832
Last modified:February 6, 2007 - v1
Checksum:i66A164AED8AB7224
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000509 Genomic DNA. Translation: ABL83745.1.
RefSeqiWP_011757674.1. NC_008699.1.

Genome annotation databases

EnsemblBacteriaiABL83745; ABL83745; Noca_4248.
KEGGinca:Noca_4248.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMSHD_NOCSJ
AccessioniPrimary (citable) accession number: A1SPL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: February 6, 2007
Last modified: June 7, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families