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Protein

tRNA dimethylallyltransferase

Gene

miaA

Organism
Nocardioides sp. (strain ATCC BAA-499 / JS614)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i6A).UniRule annotation

Catalytic activityi

Dimethylallyl diphosphate + adenine(37) in tRNA = diphosphate + N6-dimethylallyladenine(37) in tRNA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processtRNA processing
LigandATP-binding, Magnesium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA dimethylallyltransferaseUniRule annotation (EC:2.5.1.75UniRule annotation)
Alternative name(s):
Dimethylallyl diphosphate:tRNA dimethylallyltransferaseUniRule annotation
Short name:
DMAPP:tRNA dimethylallyltransferaseUniRule annotation
Short name:
DMATaseUniRule annotation
Isopentenyl-diphosphate:tRNA isopentenyltransferaseUniRule annotation
Short name:
IPP transferaseUniRule annotation
Short name:
IPPTUniRule annotation
Short name:
IPTaseUniRule annotation
Gene namesi
Name:miaAUniRule annotation
Ordered Locus Names:Noca_3843
OrganismiNocardioides sp. (strain ATCC BAA-499 / JS614)
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesNocardioidaceaeNocardioides
Proteomesi
  • UP000000640 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000206281 – 310tRNA dimethylallyltransferaseAdd BLAST310

Proteomic databases

PRIDEiA1SNF6

Interactioni

Subunit structurei

Monomer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei106Interaction with substrate tRNAUniRule annotation1
Sitei127Interaction with substrate tRNAUniRule annotation1

Protein-protein interaction databases

STRINGi196162.Noca_3843

Structurei

3D structure databases

ProteinModelPortaliA1SNF6
SMRiA1SNF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 22Substrate bindingUniRule annotation6

Sequence similaritiesi

Belongs to the IPP transferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DKX Bacteria
COG0324 LUCA
HOGENOMiHOG000039995
KOiK00791
OMAiGTGLYIR
OrthoDBiPOG091H00NK

Family and domain databases

HAMAPiMF_00185 IPP_trans, 1 hit
InterProiView protein in InterPro
IPR018022 IPT
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01715 IPPT, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00174 miaA, 1 hit

Sequencei

Sequence statusi: Complete.

A1SNF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTPNRTPI VAVVGATASG KTGLSLDLAE RLRGEIVNTD AMQVYRGMDI
60 70 80 90 100
GTAKLPVAER RGIPHHLLDT LTVRDPATVA EFQSWARAEI AEIRGRGRTP
110 120 130 140 150
VLVGGSALYT RAILDRFEFP GTDEAVRRRL EAELDALGPA ALHERLRAVD
160 170 180 190 200
PEAATRILVE NGRRIVRALE VVEITGRPFT ASLPTMEYAD PRTVQVGVDI
210 220 230 240 250
DRPTLDARIV ARVDAMFAAG FVEEVERLLA EGLAEGRTAG RAIGYREVAS
260 270 280 290 300
YLTGELSLAE ARERTVSATR RFSRRQDSWF RKDPRVTWIR YDDPGLVDRA
310
VSVVAATLDG
Length:310
Mass (Da):33,993
Last modified:February 6, 2007 - v1
Checksum:i268B20CDD4FB7E57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000509 Genomic DNA Translation: ABL83341.1
RefSeqiWP_011757272.1, NC_008699.1

Genome annotation databases

EnsemblBacteriaiABL83341; ABL83341; Noca_3843
KEGGinca:Noca_3843

Similar proteinsi

Entry informationi

Entry nameiMIAA_NOCSJ
AccessioniPrimary (citable) accession number: A1SNF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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