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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Nocardioides sp. (strain ATCC BAA-499 / JS614)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei175UniRule annotation1
Active sitei201UniRule annotation1
Active sitei297UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:Noca_3599
OrganismiNocardioides sp. (strain ATCC BAA-499 / JS614)
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesNocardioidaceaeNocardioides
Proteomesi
  • UP000000640 Componenti: Chromosome

Subcellular locationi

A1SMR4:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000755911 – 366Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei564-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi196162.Noca_3599.

Structurei

3D structure databases

ProteinModelPortaliA1SMR4.
SMRiA1SMR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 123Response regulatoryPROSITE-ProRule annotationAdd BLAST119
Domaini163 – 355CheB-type methylesteraseUniRule annotationAdd BLAST193

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151424.
KOiK03412.
OMAiMLEMHRA.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C_ter.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

A1SMR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGIRVLVVD DSVVIRKLVS DLLSADPDIE VVGTAVNGRA ALQKVAQLRP
60 70 80 90 100
DLVTMDIEMP EMDGIESVRA IRATGNKVPI IMFSTLTERG AVATLDALGA
110 120 130 140 150
GASDYVPKPA NVGSVGRSME QVREALIPRI KSLVPRRGIT PHPAGVTVAP
160 170 180 190 200
TATVQLHAPA TPPLGGHRLL VIGSSTGGPE ALSALLHTLP PLSVPVAVVQ
210 220 230 240 250
HMPPLFTRQF AARLDRQLPY DVVEAEHNQP LRPGTVAIAP GDYHLEVTTD
260 270 280 290 300
AAGLRTRLTQ APPENYCRPA VDVLFRSAVA AVGPAVLAAV LTGMGSDGCK
310 320 330 340 350
GARLIVERGG SVLAQDQATS VVWGMPGAVA TAGLAERVLP LLELGPEILR
360
RLARQRPSLV PAGALS
Length:366
Mass (Da):38,224
Last modified:February 6, 2007 - v1
Checksum:iA8548AC96A3B7794
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000509 Genomic DNA. Translation: ABL83099.1.
RefSeqiWP_011757030.1. NC_008699.1.

Genome annotation databases

EnsemblBacteriaiABL83099; ABL83099; Noca_3599.
KEGGinca:Noca_3599.

Similar proteinsi

Entry informationi

Entry nameiCHEB_NOCSJ
AccessioniPrimary (citable) accession number: A1SMR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: October 25, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome