Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A1SMR4

- CHEB_NOCSJ

UniProt

A1SMR4 - CHEB_NOCSJ

Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Nocardioides sp. (strain BAA-499 / JS614)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

    Catalytic activityi

    Protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei175 – 1751UniRule annotation
    Active sitei201 – 2011UniRule annotation
    Active sitei297 – 2971UniRule annotation

    GO - Molecular functioni

    1. phosphorelay response regulator activity Source: InterPro
    2. protein-glutamate methylesterase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. chemotaxis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    BioCyciNSP196162:GH4V-3648-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
    Gene namesi
    Name:cheBUniRule annotation
    Ordered Locus Names:Noca_3599
    OrganismiNocardioides sp. (strain BAA-499 / JS614)
    Taxonomic identifieri196162 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaeNocardioidaceaeNocardioides
    ProteomesiUP000000640: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 366366Chemotaxis response regulator protein-glutamate methylesterasePRO_1000075591Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei56 – 5614-aspartylphosphateUniRule annotation

    Post-translational modificationi

    Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi196162.Noca_3599.

    Structurei

    3D structure databases

    ProteinModelPortaliA1SMR4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 123119Response regulatoryUniRule annotationAdd
    BLAST
    Domaini163 – 355193CheB-type methylesteraseUniRule annotationAdd
    BLAST

    Domaini

    The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

    Sequence similaritiesi

    Contains 1 cheB-type methylesterase domain.UniRule annotation
    Contains 1 response regulatory domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2201.
    HOGENOMiHOG000151424.
    KOiK03412.
    OMAiEVVDLHQ.
    OrthoDBiEOG6PKFC7.

    Family and domain databases

    Gene3Di3.40.50.180. 1 hit.
    HAMAPiMF_00099. CheB_methylest.
    InterProiIPR011006. CheY-like_superfamily.
    IPR008248. Sig_transdc_resp-reg_CheB.
    IPR000673. Sig_transdc_resp-reg_Me-estase.
    IPR001789. Sig_transdc_resp-reg_receiver.
    [Graphical view]
    PfamiPF01339. CheB_methylest. 1 hit.
    PF00072. Response_reg. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
    SMARTiSM00448. REC. 1 hit.
    [Graphical view]
    SUPFAMiSSF52172. SSF52172. 1 hit.
    SSF52738. SSF52738. 1 hit.
    PROSITEiPS50122. CHEB. 1 hit.
    PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1SMR4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGIRVLVVD DSVVIRKLVS DLLSADPDIE VVGTAVNGRA ALQKVAQLRP    50
    DLVTMDIEMP EMDGIESVRA IRATGNKVPI IMFSTLTERG AVATLDALGA 100
    GASDYVPKPA NVGSVGRSME QVREALIPRI KSLVPRRGIT PHPAGVTVAP 150
    TATVQLHAPA TPPLGGHRLL VIGSSTGGPE ALSALLHTLP PLSVPVAVVQ 200
    HMPPLFTRQF AARLDRQLPY DVVEAEHNQP LRPGTVAIAP GDYHLEVTTD 250
    AAGLRTRLTQ APPENYCRPA VDVLFRSAVA AVGPAVLAAV LTGMGSDGCK 300
    GARLIVERGG SVLAQDQATS VVWGMPGAVA TAGLAERVLP LLELGPEILR 350
    RLARQRPSLV PAGALS 366
    Length:366
    Mass (Da):38,224
    Last modified:February 6, 2007 - v1
    Checksum:iA8548AC96A3B7794
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000509 Genomic DNA. Translation: ABL83099.1.
    RefSeqiWP_011757030.1. NC_008699.1.
    YP_924786.1. NC_008699.1.

    Genome annotation databases

    EnsemblBacteriaiABL83099; ABL83099; Noca_3599.
    GeneIDi4599402.
    KEGGinca:Noca_3599.
    PATRICi22749301. VBINocSp122728_3882.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000509 Genomic DNA. Translation: ABL83099.1 .
    RefSeqi WP_011757030.1. NC_008699.1.
    YP_924786.1. NC_008699.1.

    3D structure databases

    ProteinModelPortali A1SMR4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196162.Noca_3599.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL83099 ; ABL83099 ; Noca_3599 .
    GeneIDi 4599402.
    KEGGi nca:Noca_3599.
    PATRICi 22749301. VBINocSp122728_3882.

    Phylogenomic databases

    eggNOGi COG2201.
    HOGENOMi HOG000151424.
    KOi K03412.
    OMAi EVVDLHQ.
    OrthoDBi EOG6PKFC7.

    Enzyme and pathway databases

    BioCyci NSP196162:GH4V-3648-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.180. 1 hit.
    HAMAPi MF_00099. CheB_methylest.
    InterProi IPR011006. CheY-like_superfamily.
    IPR008248. Sig_transdc_resp-reg_CheB.
    IPR000673. Sig_transdc_resp-reg_Me-estase.
    IPR001789. Sig_transdc_resp-reg_receiver.
    [Graphical view ]
    Pfami PF01339. CheB_methylest. 1 hit.
    PF00072. Response_reg. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000876. RR_chemtxs_CheB. 1 hit.
    SMARTi SM00448. REC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52172. SSF52172. 1 hit.
    SSF52738. SSF52738. 1 hit.
    PROSITEi PS50122. CHEB. 1 hit.
    PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Nocardioides sp. JS614."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.
      , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BAA-499 / JS614.

    Entry informationi

    Entry nameiCHEB_NOCSJ
    AccessioniPrimary (citable) accession number: A1SMR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3