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A1SMR4

- CHEB_NOCSJ

UniProt

A1SMR4 - CHEB_NOCSJ

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Protein
Chemotaxis response regulator protein-glutamate methylesterase
Gene
cheB, Noca_3599
Organism
Nocardioides sp. (strain BAA-499 / JS614)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR By similarity.UniRule annotation

Catalytic activityi

Protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei175 – 1751 By similarity
Active sitei201 – 2011 By similarity
Active sitei297 – 2971 By similarity

GO - Molecular functioni

  1. phosphorelay response regulator activity Source: InterPro
  2. protein-glutamate methylesterase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. chemotaxis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

BioCyciNSP196162:GH4V-3648-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase (EC:3.1.1.61)
Gene namesi
Name:cheB
Ordered Locus Names:Noca_3599
OrganismiNocardioides sp. (strain BAA-499 / JS614)
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaeNocardioidaceaeNocardioides
ProteomesiUP000000640: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation
PRO_1000075591Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 5614-aspartylphosphate By similarity

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain By similarity.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi196162.Noca_3599.

Structurei

3D structure databases

ProteinModelPortaliA1SMR4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 123119Response regulatory
Add
BLAST
Domaini163 – 355193CheB-type methylesterase
Add
BLAST

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain By similarity.UniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2201.
HOGENOMiHOG000151424.
KOiK03412.
OMAiEVVDLHQ.
OrthoDBiEOG6PKFC7.

Family and domain databases

Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest.
InterProiIPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiPS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1SMR4-1 [UniParc]FASTAAdd to Basket

« Hide

MPGIRVLVVD DSVVIRKLVS DLLSADPDIE VVGTAVNGRA ALQKVAQLRP    50
DLVTMDIEMP EMDGIESVRA IRATGNKVPI IMFSTLTERG AVATLDALGA 100
GASDYVPKPA NVGSVGRSME QVREALIPRI KSLVPRRGIT PHPAGVTVAP 150
TATVQLHAPA TPPLGGHRLL VIGSSTGGPE ALSALLHTLP PLSVPVAVVQ 200
HMPPLFTRQF AARLDRQLPY DVVEAEHNQP LRPGTVAIAP GDYHLEVTTD 250
AAGLRTRLTQ APPENYCRPA VDVLFRSAVA AVGPAVLAAV LTGMGSDGCK 300
GARLIVERGG SVLAQDQATS VVWGMPGAVA TAGLAERVLP LLELGPEILR 350
RLARQRPSLV PAGALS 366
Length:366
Mass (Da):38,224
Last modified:February 6, 2007 - v1
Checksum:iA8548AC96A3B7794
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000509 Genomic DNA. Translation: ABL83099.1.
RefSeqiWP_011757030.1. NC_008699.1.
YP_924786.1. NC_008699.1.

Genome annotation databases

EnsemblBacteriaiABL83099; ABL83099; Noca_3599.
GeneIDi4599402.
KEGGinca:Noca_3599.
PATRICi22749301. VBINocSp122728_3882.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000509 Genomic DNA. Translation: ABL83099.1 .
RefSeqi WP_011757030.1. NC_008699.1.
YP_924786.1. NC_008699.1.

3D structure databases

ProteinModelPortali A1SMR4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196162.Noca_3599.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL83099 ; ABL83099 ; Noca_3599 .
GeneIDi 4599402.
KEGGi nca:Noca_3599.
PATRICi 22749301. VBINocSp122728_3882.

Phylogenomic databases

eggNOGi COG2201.
HOGENOMi HOG000151424.
KOi K03412.
OMAi EVVDLHQ.
OrthoDBi EOG6PKFC7.

Enzyme and pathway databases

BioCyci NSP196162:GH4V-3648-MONOMER.

Family and domain databases

Gene3Di 3.40.50.180. 1 hit.
HAMAPi MF_00099. CheB_methylest.
InterProi IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view ]
Pfami PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view ]
PIRSFi PIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTi SM00448. REC. 1 hit.
[Graphical view ]
SUPFAMi SSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEi PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Nocardioides sp. JS614."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.
    , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BAA-499 / JS614.

Entry informationi

Entry nameiCHEB_NOCSJ
AccessioniPrimary (citable) accession number: A1SMR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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