Reviewed,
UniProtKB/Swiss-Prot A1SMP7 (FOLD2_NOCSJ)
Last modified
January 19, 2010.
Version 24.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Bifunctional protein folD 2 Including the following 2 domains: 1- Recommended name: Methylenetetrahydrofolate dehydrogenase EC=1.5.1.5 2- Recommended name: Methenyltetrahydrofolate cyclohydrolase EC=3.5.4.9 | ||||
| Gene names |
| ||||
| Organism | Nocardioides sp. (strain BAA-499 / JS614) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 196162 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Nocardioidaceae › Nocardioides |
Protein attributes
| Sequence length | 283 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate By similarity. HAMAP MF_01576 |
| Catalytic activity | 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH. HAMAP MF_01576 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. HAMAP MF_01576 |
| Pathway | One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01576 |
| Subunit structure | Homodimer By similarity. HAMAP MF_01576 |
| Sequence similarities | Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 283 | 283 | Bifunctional protein folD 2 HAMAP MF_01576 | PRO_0000305854 | |||
Sequences
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References
| [1] | "Complete sequence of chromosome 1 of Nocardioides sp. JS614." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. Richardson P.Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000509 Genomic DNA. Translation: ABL83082.1. |
| RefSeq | YP_924769.1. |
3D structure databases | |
| SMR | A1SMP7. Positions 6-280. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A1SMP7. |
Genome annotation databases | |
| GeneID | 4599461. |
| GenomeReviews | Gene locus Noca_3582 in contig CP000509_GR. |
| KEGG | nca:Noca_3582. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0190. |
| HOGENOM | HBG328751. |
| OMA | DVVYETA. |
Family and domain databases | |
| HAMAP | MF_01576. THF_DHG_CYH. [Tree] |
| InterPro | IPR016040. NAD(P)-bd_dom. IPR000672. THF_DH/CycHdrlase. IPR020630. THF_DH/CycHdrlase_cat_dom. IPR020631. THF_DH/CycHdrlase_NAD-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF00763. THF_DHG_CYH. 1 hit. PF02882. THF_DHG_CYH_C. 1 hit. [Graphical view] |
| PRINTS | PR00085. THFDHDRGNASE. |
| PROSITE | PS00766. THF_DHG_CYH_1. False negative. PS00767. THF_DHG_CYH_2. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FOLD2_NOCSJ | ||||||||
| Accession | Primary (citable) accession number: A1SMP7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


