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A1SMP7 (FOLD2_NOCSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional protein FolD 2

Including the following 2 domains:

  1. Methylenetetrahydrofolate dehydrogenase
    EC=1.5.1.5
  2. Methenyltetrahydrofolate cyclohydrolase
    EC=3.5.4.9
Gene names
Name:folD2
Ordered Locus Names:Noca_3582
OrganismNocardioides sp. (strain BAA-499 / JS614) [Complete proteome] [HAMAP]
Taxonomic identifier196162 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaeNocardioidaceaeNocardioides

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate By similarity. HAMAP MF_01576

Catalytic activity

5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH. HAMAP MF_01576

5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. HAMAP MF_01576

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01576

Subunit structure

Homodimer By similarity. HAMAP MF_01576

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283Bifunctional protein FolD 2 HAMAP MF_01576
PRO_0000305854

Sequences

Sequence LengthMass (Da)Tools
A1SMP7 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: F66FF1AEAD723F64

FASTA28329,369
        10         20         30         40         50         60 
MTAQKLDGTA TAAAIKGELT TRVAALHERG IRPGLGTILV GDDPGSRWYV NGKHKDCAEV 

        70         80         90        100        110        120 
GIESIRIDLP ATATQDEIED AVRVLNDDPA CTGYIVQLPL PKGRDENRVL GLIDPAKDAD 

       130        140        150        160        170        180 
GLHPTNLGWL VLGKAAPLPC TPNGIVELLR RHGVEIAGAE VTVVGRGVTV GRPLGLLLTR 

       190        200        210        220        230        240 
RSENATVTLC HTGTRDLAAH VRGADIVVAA AGVPGIVTGA MVKPGAAVLD VGVSRVDGKL 

       250        260        270        280 
AGDVAPEVWD VARWVSPNPG GVGPMTRAML LSNIVAMAEQ TDS 

« Hide

References

[1]"Complete sequence of chromosome 1 of Nocardioides sp. JS614."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BAA-499 / JS614.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000509 Genomic DNA. Translation: ABL83082.1.
RefSeqYP_924769.1. NC_008699.1.

3D structure databases

ProteinModelPortalA1SMP7.
SMRA1SMP7. Positions 6-280.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1SMP7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4599461.
GenomeReviewsGene locus Noca_3582 in contig CP000509_GR.
KEGGnca:Noca_3582.
PATRIC22749267. VBINocSp122728_3865.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0190.
HOGENOMHBG328751.
OMASHKRKDC.

Enzyme and pathway databases

BioCycNSP35761:NOCA_3582-MONOMER.

Family and domain databases

HAMAPMF_01576. THF_DHG_CYH.
[Tree]
InterProIPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01491.
PfamPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSPR00085. THFDHDRGNASE.
PROSITEPS00766. THF_DHG_CYH_1. False negative.
PS00767. THF_DHG_CYH_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOLD2_NOCSJ
AccessionPrimary (citable) accession number: A1SMP7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families