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A1SMF0

- A1SMF0_NOCSJ

UniProt

A1SMF0 - A1SMF0_NOCSJ

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Protein
Alanine racemase
Gene
Noca_3485
Organism
Nocardioides sp. (strain BAA-499 / JS614)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei137 – 1371Substrate By similarityUniRule annotation
Active sitei265 – 2651Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei313 – 3131Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciNSP196162:GH4V-3534-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Noca_3485Imported
OrganismiNocardioides sp. (strain BAA-499 / JS614)Imported
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaeNocardioidaceaeNocardioides
ProteomesiUP000000640: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi196162.Noca_3485.

Structurei

3D structure databases

ProteinModelPortaliA1SMF0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiFIMSHLA.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

A1SMF0-1 [UniParc]FASTAAdd to Basket

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MTILLADRQR TGAGPRPDID LAAVAHNTRL LAGRATGELM AVVKADDFGH    50
GAVELARTAL ANGATWLGVT TIDEALALRA AGLTAPLLSW LNPVDADLAA 100
AVRAGVDLGV PGLPHLDATT AARGARVHLH VDAGMARDGA APATWGQLCR 150
AARRAEQRGE IQVVGVMGHL GCAEDPTDEC NALGRTRFAW ALETARAAGL 200
RPAHRHLAAT AATLTDPRSH HTMSRVGAGL VGIDPSHTTR LRPALTLIAP 250
VVQVRRVRGG TPVGYGHAYR TSAATHLGLV PLGYADGLPR LASGRAEVLV 300
RGRRRPVVGR ISMDQLVVDL GERPVDVGEG VTVFGPGDAG EPTVAEWAAW 350
SETIEHEIVT GIGARVPRRI GRSAHLRSLS 380
Length:380
Mass (Da):39,731
Last modified:February 6, 2007 - v1
Checksum:iC7B2AB9641F4F2A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000509 Genomic DNA. Translation: ABL82985.1.
RefSeqiWP_011756918.1. NC_008699.1.
YP_924672.1. NC_008699.1.

Genome annotation databases

EnsemblBacteriaiABL82985; ABL82985; Noca_3485.
GeneIDi4595584.
KEGGinca:Noca_3485.
PATRICi22749083. VBINocSp122728_3773.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000509 Genomic DNA. Translation: ABL82985.1 .
RefSeqi WP_011756918.1. NC_008699.1.
YP_924672.1. NC_008699.1.

3D structure databases

ProteinModelPortali A1SMF0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 196162.Noca_3485.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL82985 ; ABL82985 ; Noca_3485 .
GeneIDi 4595584.
KEGGi nca:Noca_3485.
PATRICi 22749083. VBINocSp122728_3773.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OMAi FIMSHLA.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci NSP196162:GH4V-3534-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Nocardioides sp. JS614."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.
    , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BAA-499 / JS614.

Entry informationi

Entry nameiA1SMF0_NOCSJ
AccessioniPrimary (citable) accession number: A1SMF0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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