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A1SME1 (A1SME1_NOCSJ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP-dependent Clp protease proteolytic subunit 3 HAMAP MF_00444
EC=3.4.21.92 HAMAP MF_00444
Alternative name(s):
Endopeptidase Clp 3 HAMAP MF_00444
Gene names
Name:clpP3 HAMAP MF_00444
Ordered Locus Names:Noca_3476
OrganismNocardioides sp. (strain BAA-499 / JS614) [Complete proteome] [HAMAP]
Taxonomic identifier196162 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Nocardioidaceae › Nocardioides

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP MF_00444 RuleBase RU000550

Catalytic activity

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444 RuleBase RU000549

Subcellular location

Cytoplasm By similarity HAMAP MF_00444.

Sequence similarities

Belongs to the peptidase S14 family. HAMAP MF_00444 RuleBase RU003567

Ontologies

Keywords
   Cellular componentCytoplasm HAMAP MF_00444
   LigandATP-binding HAMAP MF_00444
Nucleotide-binding
   Molecular functionHydrolase
Protease
Serine protease HAMAP MF_00444 RuleBase RU000549
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type endopeptidase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1021 By similarity HAMAP MF_00444
Active site1271 By similarity HAMAP MF_00444

Sequences

Sequence LengthMass (Da)Tools
A1SME1 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 53524A0EADD3DD13

FASTA20622,687
        10         20         30         40         50         60 
MSEMNYYIPQ WEERTSYGFR RIDPYAKLFE DRIIYLGTPI SDDVANAVIA QLLCLQSMNP 

        70         80         90        100        110        120 
DQDISIYINS PGGSFTALTA IYDTMKFIKP DVQTVCIGQA ASAAAILLAA GTPGKRLALP 

       130        140        150        160        170        180 
NSRILIHQPY TEGTFGQTSD IEIQANEILR MRELLEKMIS DHSGRSIEEV SHDIERDKIL 

       190        200 
TAEGAVEYGL IDAVLESLKG TPAVAG

« Hide

References

[1]"Complete sequence of chromosome 1 of Nocardioides sp. JS614."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BAA-499 / JS614.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000509 Genomic DNA. Translation: ABL82976.1.
RefSeqYP_924663.1. NC_008699.1.

3D structure databases

ProteinModelPortalA1SME1.
SMRA1SME1. Positions 17-197.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1SME1.

Protein family/group databases

MEROPSS14.009.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4595573.
GenomeReviewsGene locus Noca_3476 in contig CP000509_GR.
KEGGnca:Noca_3476.
PATRIC22749061. VBINocSp122728_3764.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0740.
HOGENOMHBG558421.
OMAQDPYTKL.
ProtClustDBCLSK2783710.

Enzyme and pathway databases

BioCycNSP35761:NOCA_3476-MONOMER.

Family and domain databases

HAMAPMF_00444. ClpP.
[Tree]
InterProIPR023562. Pept_S14/S49.
IPR001907. Pept_S14_ClpP.
IPR018215. Pept_S14_ClpP_AS.
[Graphical view]
KOK01358.
PANTHERPTHR10381. Pept_S14_ClpP. 1 hit.
PfamPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSPR00127. CLPPROTEASEP.
PROSITEPS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1SME1_NOCSJ
AccessionPrimary (citable) accession number: A1SME1
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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