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Protein

Ribonuclease 3

Gene

rnc

Organism
Nocardioides sp. (strain ATCC BAA-499 / JS614)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi75MagnesiumUniRule annotation1
Active sitei79UniRule annotation1
Metal bindingi148MagnesiumUniRule annotation1
Active sitei151UniRule annotation1
Metal bindingi151MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease, RNA-binding, rRNA-bindingUniRule annotationSAAS annotation
Biological processmRNA processingUniRule annotationSAAS annotation, rRNA processingUniRule annotationSAAS annotation, tRNA processingUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:Noca_3281Imported
OrganismiNocardioides sp. (strain ATCC BAA-499 / JS614)Imported
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesNocardioidaceaeNocardioides
Proteomesi
  • UP000000640 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500263683520 – 276Ribonuclease 3Sequence analysisAdd BLAST257

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi196162.Noca_3281

Structurei

3D structure databases

ProteinModelPortaliA1SLU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 162RNase IIIInterPro annotationAdd BLAST128
Domaini189 – 257DRBMInterPro annotationAdd BLAST69

Sequence similaritiesi

Belongs to the ribonuclease III family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG4108ZBM Bacteria
COG0571 LUCA
HOGENOMiHOG000246808
KOiK03685
OMAiLTHKSCK
OrthoDBiPOG091H00R1

Family and domain databases

CDDicd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

A1SLU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSTCRTARA ASAASTARAP TVVRSSDPTG PLTNYAELRA ALGDPTLDPE
60 70 80 90 100
LLERALTHRS FAYENGGLPT NERLEFLGDS VLGVVVTETL YLKHPDLSEG
110 120 130 140 150
RLAKLRAAVV NARALAEVGR RIGVGEHVKL GRGEESTGGR HKASILSDTV
160 170 180 190 200
EAVIGAVHLS GGFTTSAVVV HRLFDPLIEA ASALGAGLDW KTSLQELSAE
210 220 230 240 250
HGLGVPEYVI EDDGPDHMKT FTAQVRVGEG LYGNGVGRSK KEAEQAAAET
260 270
AYGEIASDLG VDDPAVDAAA HSAHKS
Length:276
Mass (Da):28,866
Last modified:February 6, 2007 - v1
Checksum:i20475DE0CDBB5325
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000509 Genomic DNA Translation: ABL82783.1
RefSeqiWP_011756717.1, NC_008699.1

Genome annotation databases

EnsemblBacteriaiABL82783; ABL82783; Noca_3281
KEGGinca:Noca_3281

Similar proteinsi

Entry informationi

Entry nameiA1SLU8_NOCSJ
AccessioniPrimary (citable) accession number: A1SLU8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health