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A1SLM1 (A1SLM1_NOCSJ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
Short name=DXP reductoisomerase HAMAP MF_00183
EC=1.1.1.267 HAMAP MF_00183
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase HAMAP MF_00183
2-C-methyl-D-erythritol 4-phosphate synthase HAMAP MF_00183
Gene names
Name:dxr HAMAP MF_00183
Ordered Locus Names:Noca_3204
OrganismNocardioides sp. (strain BAA-499 / JS614) [Complete proteome] [HAMAP]
Taxonomic identifier196162 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Nocardioidaceae › Nocardioides

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00183 SAAS SAAS003821

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183 SAAS SAAS003821

Cofactor

Divalent cation By similarity. HAMAP MF_00183 SAAS SAAS003821

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183 SAAS SAAS003821

Sequence similarities

Belongs to the DXR family. HAMAP MF_00183

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding11 – 4030NADP By similarity HAMAP MF_00183

Sites

Metal binding1321Divalent metal cation By similarity HAMAP MF_00183
Metal binding1341Divalent metal cation By similarity HAMAP MF_00183
Metal binding2031Divalent metal cation By similarity HAMAP MF_00183
Binding site1091Substrate By similarity HAMAP MF_00183
Binding site1341Substrate By similarity HAMAP MF_00183
Binding site1581Substrate By similarity HAMAP MF_00183
Binding site1811Substrate By similarity HAMAP MF_00183
Binding site2031Substrate By similarity HAMAP MF_00183

Sequences

Sequence LengthMass (Da)Tools
A1SLM1 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: BB5B89E1F2F462F7

FASTA37239,484
        10         20         30         40         50         60 
MSRPVRDVAI LGSTGSIGTQ ALDLVRANPD RFRVVALTAG GSSPELFERQ VAEFAPAYPD 

        70         80         90        100        110        120 
LFSGLGEEAS VEAATRPCDV VLNGITGAVG LRPTLAALDA GHTLALANKE SLIMGGPLVL 

       130        140        150        160        170        180 
ERAKPGQIVP VDSEHSAIAQ CLRGGRADEV RRLVLTASGG PFRGRTREEL ADVTPAQAMA 

       190        200        210        220        230        240 
HPTWDMGPVI TINSATLVNK GLEVIEAHLL FGIPFDRIEV VVHPTSVVHS MVEFVDGSTL 

       250        260        270        280        290        300 
VQASPPTMLI PIALGLSWPD RVPDAAPPVD WSRPETWEFF PLDDAAFPAV ALAREAGQRG 

       310        320        330        340        350        360 
GTAPAVYNAA NEVAVDAFRT GALAFTEIVP TVQAVLSRHD VPSEVTIEDI LAADAWAREA 

       370 
TRTRLRPDQI ED

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References

[1]"Complete sequence of chromosome 1 of Nocardioides sp. JS614."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BAA-499 / JS614.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000509 Genomic DNA. Translation: ABL82706.1.
RefSeqYP_924393.1. NC_008699.1.

3D structure databases

ProteinModelPortalA1SLM1.
SMRA1SLM1. Positions 6-365.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1SLM1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4599067.
GenomeReviewsGene locus Noca_3204 in contig CP000509_GR.
KEGGnca:Noca_3204.
PATRIC22748489. VBINocSp122728_3478.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0743.
HOGENOMHBG430762.
OMAIHSMVEY.
PhylomeDBA1SLM1.
ProtClustDBPRK05447.

Enzyme and pathway databases

BioCycNSP35761:NOCA_3204-MONOMER.

Family and domain databases

HAMAPMF_00183. DXP_reductoisom.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00099.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 2 hits.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA1SLM1_NOCSJ
AccessionPrimary (citable) accession number: A1SLM1
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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