A1SLA0 (A1SLA0_NOCSJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

Ordered Locus Names:

Noca_3083

Organism

Nocardioides sp. (strain BAA-499 / JS614) [Complete proteome] [HAMAP]

Taxonomic identifier

196162 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Nocardioidaceae › Nocardioides

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU004255
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004255
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862 EMBL ABL82585.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1SLA0 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 8B21862B863D52BB	FASTA	296	32,178
	10 20 30 40 50 60 MANQRTRRIG DLVREGERSF SFEFFPPRDE AGEEQLWCAI RELESFRPTF VSVTYGAGGT 70 80 90 100 110 120 TRHSTVRITE RIAAETSLTA MAHLTCVGHT RAELETILDT YAEAGIGNVM ALRGDPAEGP 130 140 150 160 170 180 RAEWAPTDGG LTYAEELVRL VRGRGDFSVG VAAFPEGHPS ATSLDHDADV LVAKARAGAE 190 200 210 220 230 240 FAVTQMFFRA SDYFALVQRV RDRGVDLPIL PGIMPILNLA NIRRQGELIG TEVPAEVVRR 250 260 270 280 290 ISAHDGDPMA MRAEGIAIAA ELCDELLAGG APGLHFYTLN RSKATREIFA ALNLPV

References

[1]

"Complete sequence of chromosome 1 of Nocardioides sp. JS614." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BAA-499 / JS614.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000509 Genomic DNA. Translation: ABL82585.1.
RefSeq	YP_924272.1. NC_008699.1.
3D structure databases
ProteinModelPortal	A1SLA0.
ModBase	Search...
Protein-protein interaction databases
STRING	A1SLA0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4597868.
GenomeReviews	Gene locus Noca_3083 in contig CP000509_GR.
KEGG	nca:Noca_3083.
PATRIC	22748239. VBINocSp122728_3353.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0685.
HOGENOM	HBG649727.
OMA	ITQMFFD.
PhylomeDB	A1SLA0.
Enzyme and pathway databases
BioCyc	NSP35761:NOCA_3083-MONOMER.
Family and domain databases
InterPro	IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00676. Fadh2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A1SLA0_NOCSJ

Accession

Primary (citable) accession number: A1SLA0

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)