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A1SKL2

- DNLI_NOCSJ

UniProt

A1SKL2 - DNLI_NOCSJ

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Protein

Probable DNA ligase

Gene
lig, Noca_2845
Organism
Nocardioides sp. (strain BAA-499 / JS614)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei218 – 2181ATP By similarity
Active sitei220 – 2201N6-AMP-lysine intermediate By similarity
Binding sitei225 – 2251ATP By similarity
Binding sitei240 – 2401ATP By similarity
Binding sitei269 – 2691ATP By similarity
Binding sitei302 – 3021ATP By similarity
Binding sitei374 – 3741ATP By similarity
Binding sitei380 – 3801ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNSP196162:GH4V-2889-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:Noca_2845
OrganismiNocardioides sp. (strain BAA-499 / JS614)
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaeNocardioidaceaeNocardioides
ProteomesiUP000000640: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Probable DNA ligaseUniRule annotationPRO_0000365236Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196162.Noca_2845.

Structurei

3D structure databases

ProteinModelPortaliA1SKL2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK01971.
OMAiARVQVHK.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1SKL2-1 [UniParc]FASTAAdd to Basket

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MNGAVLIADV VATSAAITAT RSRKAKVAAI ADLLARADPR RSGADELETV    50
TAYVGGALRQ RRTGLGWRGL TKLPAPAPGP TLSVLEVHEA FERIAAPAGA 100
GSQAARAAAV ADLFGRATAE EQQWLRGVVT GEVRQGALDS LVQEGLAAAA 150
GVPLPEVRRA AMLAGSTVAV AAAAFEGVAA LGAVGLQVGR PVLPMLASSA 200
PDLAAALARA GGDEVAVDTK LDGIRIQVHR SGPDVVVATR SLEDITARLP 250
EVVEVARALP ADSFVLDGEA LALAEDGRPR PFQETAARTA MGAGVEVTPY 300
FFDVLHLDGA DLLDVSAAER AAVLERLVPA EHRVPRVVTA DLGVAEEFLA 350
GALRSGHEGV VVKSLAAPYE AGRRGASWVK VKPVHTLDLV VLAVEWGSGR 400
RQGWLSNIHL GARDPATGGL VMLGKTFKGM TDEVLAWQTE RFLELETSRS 450
AHVVHVRPEQ VVEIAFDGVQ RSTRYPGGVA LRFARVLRYR DDKPVAEIDT 500
VDTVRSFLG 509
Length:509
Mass (Da):53,371
Last modified:February 6, 2007 - v1
Checksum:iD1533EF8065E8329
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000509 Genomic DNA. Translation: ABL82347.1.
RefSeqiWP_011756285.1. NC_008699.1.
YP_924034.1. NC_008699.1.

Genome annotation databases

EnsemblBacteriaiABL82347; ABL82347; Noca_2845.
GeneIDi4598444.
KEGGinca:Noca_2845.
PATRICi22747747. VBINocSp122728_3108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000509 Genomic DNA. Translation: ABL82347.1 .
RefSeqi WP_011756285.1. NC_008699.1.
YP_924034.1. NC_008699.1.

3D structure databases

ProteinModelPortali A1SKL2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196162.Noca_2845.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL82347 ; ABL82347 ; Noca_2845 .
GeneIDi 4598444.
KEGGi nca:Noca_2845.
PATRICi 22747747. VBINocSp122728_3108.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K01971.
OMAi ARVQVHK.
OrthoDBi EOG6Q8HXT.

Enzyme and pathway databases

BioCyci NSP196162:GH4V-2889-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Nocardioides sp. JS614."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.
    , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BAA-499 / JS614.

Entry informationi

Entry nameiDNLI_NOCSJ
AccessioniPrimary (citable) accession number: A1SKL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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