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A1SJZ1 (UPPP_NOCSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Noca_2623
OrganismNocardioides sp. (strain BAA-499 / JS614) [Complete proteome] [HAMAP]
Taxonomic identifier196162 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaeNocardioidaceaeNocardioides

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290738

Regions

Transmembrane40 – 6021Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane190 – 21021Helical; Potential
Transmembrane221 – 24121Helical; Potential
Transmembrane252 – 27221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A1SJZ1 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 7E73EC8EACD8169E

FASTA27429,593
        10         20         30         40         50         60 
MVDFLQALVL GLIQGLTEFL PISSSAHLRI YPELFGWGDP GAAFTAVIQI GTEVAVLMFF 

        70         80         90        100        110        120 
RKDIWRIGRA WLLSLFKPEY RGHLDARMGW FIIVGSVPIV LLGIALKDVI EEDFRSLWLI 

       130        140        150        160        170        180 
GTTLIVLGLV LGVADRLGGT DKTIKQISLR DAILMGLAQA LALIPGVSRS GATLSMGRLL 

       190        200        210        220        230        240 
GYDREAATRY AFLLAIPAVI GAGVFELKDI PNGDNLYGWG PTIVATIVSF VVGYAAIAWL 

       250        260        270 
LRYVTTRSYA PFVLYRVALG AATLVLVATG VIAA 

« Hide

References

[1]"Complete sequence of chromosome 1 of Nocardioides sp. JS614."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BAA-499 / JS614.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000509 Genomic DNA. Translation: ABL82126.1.
RefSeqYP_923813.1. NC_008699.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196162.Noca_2623.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL82126; ABL82126; Noca_2623.
GeneID4596428.
KEGGnca:Noca_2623.
PATRIC22747297. VBINocSp122728_2883.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycNSP196162:GH4V-2667-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_NOCSJ
AccessionPrimary (citable) accession number: A1SJZ1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 6, 2007
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families