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A1SJJ4 (ARLY_NOCSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:Noca_2475
OrganismNocardioides sp. (strain BAA-499 / JS614) [Complete proteome] [HAMAP]
Taxonomic identifier196162 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Nocardioidaceae › Nocardioides

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Argininosuccinate lyase HAMAP MF_00006
PRO_0000321444

Sequences

Sequence LengthMass (Da)Tools
A1SJJ4 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: DBF2DDCE3F27D4B9

FASTA47050,113
        10         20         30         40         50         60 
MGTNTGKLWG GRFAGGPSPE LDALSRSTHF DWRLTPYDLA GSRAHANALH RAGLLTDADL 

        70         80         90        100        110        120 
AELRRGLDAL GERYAAGTLR PDPSDEDVHG ALERLLVDEV GPEVGGRLRA GRSRNDQIAT 

       130        140        150        160        170        180 
LFKVFLRDHA AVVAGQVLDL VDALAGQARA AGDAVMPGRT HLQHAQPVLL AHHLLAHCWA 

       190        200        210        220        230        240 
LLRDVDRLRD WDARVAADSP YGSGALAGSS LGLDPEGVAA ELGFSGSSAN SIDGTASRDF 

       250        260        270        280        290        300 
VAEFAYVTAQ IGVDVSRIAE EVILWSTREF GFVTLHDSWS TGSSIMPQKK NPDIAELARG 

       310        320        330        340        350        360 
KAGRLIGNLS GLLATLKALP LAYNRDLQED KEPVFDSVDT LEVLLPAFTG LVATLAFDTE 

       370        380        390        400        410        420 
RMADLAPQGF SLATDVAEWL VREGVPFRIA HEVAGACVRR CEELGIELAD LTDEQFAEIS 

       430        440        450        460        470 
PALTPGVREV LSVAGSVSAR DGRGGTAPIR VREQLAELTG LVDGHRDRLG

« Hide

References

[1]"Complete sequence of chromosome 1 of Nocardioides sp. JS614."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BAA-499 / JS614.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000509 Genomic DNA. Translation: ABL81979.1.
RefSeqYP_923666.1. NC_008699.1.

3D structure databases

ProteinModelPortalA1SJJ4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1SJJ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4597097.
GenomeReviewsGene locus Noca_2475 in contig CP000509_GR.
KEGGnca:Noca_2475.
PATRIC22746981. VBINocSp122728_2730.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
HOGENOMHBG539632.
OMAMPGRTHL.
PhylomeDBA1SJJ4.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycNSP35761:NOCA_2475-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_NOCSJ
AccessionPrimary (citable) accession number: A1SJJ4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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