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A1SJJ3

- ASSY_NOCSJ

UniProt

A1SJJ3 - ASSY_NOCSJ

Protein

Argininosuccinate synthase

Gene

argG

Organism
Nocardioides sp. (strain BAA-499 / JS614)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431ATPUniRule annotation
    Binding sitei99 – 991CitrullineUniRule annotation
    Binding sitei129 – 1291ATP; via amide nitrogenUniRule annotation
    Binding sitei131 – 1311AspartateUniRule annotation
    Binding sitei131 – 1311ATPUniRule annotation
    Binding sitei135 – 1351AspartateUniRule annotation
    Binding sitei135 – 1351CitrullineUniRule annotation
    Binding sitei136 – 1361AspartateUniRule annotation
    Binding sitei136 – 1361ATPUniRule annotation
    Binding sitei139 – 1391CitrullineUniRule annotation
    Binding sitei192 – 1921CitrullineUniRule annotation
    Binding sitei194 – 1941ATPUniRule annotation
    Binding sitei201 – 2011CitrullineUniRule annotation
    Binding sitei203 – 2031CitrullineUniRule annotation
    Binding sitei280 – 2801CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 259ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNSP196162:GH4V-2513-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:Noca_2474
    OrganismiNocardioides sp. (strain BAA-499 / JS614)
    Taxonomic identifieri196162 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaeNocardioidaceaeNocardioides
    ProteomesiUP000000640: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 477477Argininosuccinate synthasePRO_1000025435Add
    BLAST

    Proteomic databases

    PRIDEiA1SJJ3.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi196162.Noca_2474.

    Structurei

    3D structure databases

    ProteinModelPortaliA1SJJ3.
    SMRiA1SJJ3. Positions 2-424.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230094.
    KOiK01940.
    OMAiRQEMSEF.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00581. Arg_succ_synth_type2.
    InterProiIPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1SJJ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKVLTSLPV GQRVGIAFSG GLDTSVAVAW MRDKGAIPCT YTADIGQYDE    50
    PDVSGVPARA REYGAEIARV VDCRAQLVEE GLAALACGAF HIRSGGRIYF 100
    NTTPLGRAVT GTILVRAMHE DGVDIWGDGS TFKGNDIERF YRYGLLANPQ 150
    LRIYKPWLDP DFVHELGGRT EMSQWLTSHG LPYRDSQEKA YSTDANIWGA 200
    THEAKTLEHL DTSLEVVTPI MGVRFWDPAV DIATEDVTVA FEQGRPVALN 250
    GRRFDDPVEL VEEANAIGGR HGLGMSDQIE NRIIEAKSRG VYEAPGMALL 300
    WLTYERLMNA IHNEDTLANY QISGRRLGRL LYEGRWLDPQ ALMLRESIQR 350
    WVASVVTGEV TVRLRRGEDY TIVRTEGPAL SYHPEKLSME RTSNSAFGPT 400
    DRIGQLTMRN LDIADSRAML EMYAGQPLDQ GQVLVENGTL FGELPSGGFD 450
    QITENPEVQA EPEEEALDAA AMEAGTD 477
    Length:477
    Mass (Da):52,669
    Last modified:February 6, 2007 - v1
    Checksum:i7D9B62C30D9A15EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000509 Genomic DNA. Translation: ABL81978.1.
    RefSeqiWP_011755919.1. NC_008699.1.
    YP_923665.1. NC_008699.1.

    Genome annotation databases

    EnsemblBacteriaiABL81978; ABL81978; Noca_2474.
    GeneIDi4597096.
    KEGGinca:Noca_2474.
    PATRICi22746979. VBINocSp122728_2729.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000509 Genomic DNA. Translation: ABL81978.1 .
    RefSeqi WP_011755919.1. NC_008699.1.
    YP_923665.1. NC_008699.1.

    3D structure databases

    ProteinModelPortali A1SJJ3.
    SMRi A1SJJ3. Positions 2-424.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196162.Noca_2474.

    Proteomic databases

    PRIDEi A1SJJ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL81978 ; ABL81978 ; Noca_2474 .
    GeneIDi 4597096.
    KEGGi nca:Noca_2474.
    PATRICi 22746979. VBINocSp122728_2729.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230094.
    KOi K01940.
    OMAi RQEMSEF.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci NSP196162:GH4V-2513-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00581. Arg_succ_synth_type2.
    InterProi IPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Nocardioides sp. JS614."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.
      , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BAA-499 / JS614.

    Entry informationi

    Entry nameiASSY_NOCSJ
    AccessioniPrimary (citable) accession number: A1SJJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3