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A1SJE9 (A1SJE9_NOCSJ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase RuleBase RU003441
EC=3.5.2.3 RuleBase RU003441
Gene names
Ordered Locus Names:Noca_2429
OrganismNocardioides sp. (strain BAA-499 / JS614) [Complete proteome] [HAMAP]
Taxonomic identifier196162 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Nocardioidaceae › Nocardioides

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. RuleBase RU003441 SAAS SAAS002195

Cofactor

Binds 2 zinc ions per subunit By similarity. RuleBase RU003441 SAAS SAAS002195

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. RuleBase RU003441 SAAS SAAS002195

Subunit structure

Homodimer By similarity. SAAS SAAS002195

Sequence similarities

Belongs to the DHOase family. Type 2 subfamily. RuleBase RU003441

Sequences

Sequence LengthMass (Da)Tools
A1SJE9 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: B9FD610546DF81EC

FASTA43245,915
        10         20         30         40         50         60 
MSTSYLIKNV SVLGGTPTDL LLEDGVIREA ADRPDAEVID ATGLIALPGL VDLHTHLREP 

        70         80         90        100        110        120 
GREDAETVET GTHAAAMGGF TAVHAMANTE PVADTAGVVE QVWRLGREAG YCDVFPVGAV 

       130        140        150        160        170        180 
TVGLQGERLA ELGAMADSAA RVRVFSDDGK CVSDAVLMRR ALEYVKAFDG VVAQHAQEPR 

       190        200        210        220        230        240 
LTEGAQMNEG ELSGRLGLAG WPAVAEEAII ARDLLLAEHV GSRLHVCHVS TAGSVELIRW 

       250        260        270        280        290        300 
AKAKAEKDGH WEVTAEACPH HLLLTDELAA TYDPIYKVNP PLRTAADAQA LRAGLADGTI 

       310        320        330        340        350        360 
DIVATDHAPH PHEDKDCEWA AAAFGMLGLE TALSVVQQTM VDTGLLDWAG LAERMSYAPA 

       370        380        390        400        410        420 
RIGRVSDQHG RPVAIGEPAN MVLYDPGATR TIDPSESASL SRNTPYRGME LPGRVVATFL 

       430 
RGRATVLDGK LQ

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References

[1]"Complete sequence of chromosome 1 of Nocardioides sp. JS614."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BAA-499 / JS614.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000509 Genomic DNA. Translation: ABL81934.1.
RefSeqYP_923621.1. NC_008699.1.

3D structure databases

ProteinModelPortalA1SJE9.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1SJE9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4598265.
GenomeReviewsGene locus Noca_2429 in contig CP000509_GR.
KEGGnca:Noca_2429.
PATRIC22746887. VBINocSp122728_2683.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0044.
HOGENOMHBG724623.
OMACDVHPVG.
ProtClustDBPRK09357.

Enzyme and pathway databases

BioCycNSP35761:NOCA_2429-MONOMER.

Family and domain databases

HAMAPMF_00220_B. PyrC_type2_B.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004722. DHOase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR00857. PyrC_multi. 1 hit.
PROSITEPS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1SJE9_NOCSJ
AccessionPrimary (citable) accession number: A1SJE9
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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