A1SJE8 (PYRB_NOCSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Noca_2428

Organism

Nocardioides sp. (strain BAA-499 / JS614) [Complete proteome] [HAMAP]

Taxonomic identifier

196162 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Nocardioidaceae › Nocardioides

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 324	324	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000321127

Sequences

	Sequence		Length	Mass (Da)
	A1SJE8 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 7E5EE1337FFE7A2D	FASTA	324	35,078
	10 20 30 40 50 60 MKRHLLSAGD LSRDDAELVL RTAAELRELA DRPIKKLPAL RGRTVVNLFF EDSTRTRISF 70 80 90 100 110 120 EAAAKRLSAD VINFAAKGSS LSKGESLKDT ALTLEAMGAD AVVVRHGASG APHRLAHSGW 130 140 150 160 170 180 VRSSVVNAGD GTHEHPTQAL LDAFTMWRHL GQGKEQSLDG RRIAIVGDVL HSRVARSNAL 190 200 210 220 230 240 LLKTLGAEVT LVAPPTLLPV GIDTWPVETS YDLDAVLPKA DAVMMLRVQR ERMSGGFFPT 250 260 270 280 290 300 AREYSRRYGL DGRRMATLQD HTIVMHPGPM VRGMEITADV ADSDRSVIVE QVTNGVAVRM 310 320 AVLYLLLGGS EPAVSTSSTN EAEE

References

[1]

"Complete sequence of chromosome 1 of Nocardioides sp. JS614." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BAA-499 / JS614.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000509 Genomic DNA. Translation: ABL81933.1.
RefSeq	YP_923620.1. NC_008699.1.
3D structure databases
ProteinModelPortal	A1SJE8.
ModBase	Search...
Protein-protein interaction databases
STRING	A1SJE8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4598264.
GenomeReviews	Gene locus Noca_2428 in contig CP000509_GR.
KEGG	nca:Noca_2428.
PATRIC	22746885. VBINocSp122728_2682.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HBG579429.
OMA	LQRERMS.
PhylomeDB	A1SJE8.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	NSP35761:NOCA_2428-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_NOCSJ

Accession

Primary (citable) accession number: A1SJE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program