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A1SJD2 (AROC_NOCSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:Noca_2412
OrganismNocardioides sp. (strain BAA-499 / JS614) [Complete proteome] [HAMAP]
Taxonomic identifier196162 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Nocardioidaceae › Nocardioides

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Subunit structure

Homotetramer By similarity. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Chorismate synthase HAMAP MF_00300
PRO_0000322417

Sequences

Sequence LengthMass (Da)Tools
A1SJD2 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: B2966F18BB64BCC6

FASTA39241,661
        10         20         30         40         50         60 
MLRWLTAGES HGPSLVAILE GLPAHVQVTS DDVADALARR RLGYGRGARM KFERDEVTLV 

        70         80         90        100        110        120 
GGIRHGETMG GPVAIEIGNT EWPKWEKVMA ADPVDPVELE SLARNAPLTR PRPGHADLVG 

       130        140        150        160        170        180 
MQKYDFTEAR PILERASARE TAARVALGRV ASNLLEQAVG ARIVSHVIEL GGVRAPAGLW 

       190        200        210        220        230        240 
PQPEDVDRLD DDPVRCLDAD TSKLMVEAID QAHQDGDTLG GVVEVVVHGL PPGLGSHVHW 

       250        260        270        280        290        300 
DRRLDARLAG ALMGIQAIKG VEVGDGFELA ATPGSRAHDE IVSGTDGLRR VSGRSGGTEG 

       310        320        330        340        350        360 
GMSTGEVLRV RAAMKPIATV PRALRTVDVA TGEAAVAHHQ RSDVCAVPAA GIVAEAMVAL 

       370        380        390 
VLADAVLEKF GGDSVRETRR NAEGYLDTLR FR

« Hide

References

[1]"Complete sequence of chromosome 1 of Nocardioides sp. JS614."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BAA-499 / JS614.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000509 Genomic DNA. Translation: ABL81917.1.
RefSeqYP_923604.1. NC_008699.1.

3D structure databases

ProteinModelPortalA1SJD2.
SMRA1SJD2. Positions 1-385.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1SJD2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4598248.
GenomeReviewsGene locus Noca_2412 in contig CP000509_GR.
KEGGnca:Noca_2412.
PATRIC22746853. VBINocSp122728_2666.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0082.
HOGENOMHBG292336.
OMAMLRWLTA.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycNSP35761:NOCA_2412-MONOMER.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. False negative.
PS00789. CHORISMATE_SYNTHASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_NOCSJ
AccessionPrimary (citable) accession number: A1SJD2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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