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Protein

Acetaldehyde dehydrogenase 2

Gene

Noca_2150

Organism
Nocardioides sp. (strain ATCC BAA-499 / JS614)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei133Acyl-thioester intermediateUniRule annotation1
Binding sitei289NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 18NADUniRule annotation4
Nucleotide bindingi164 – 172NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Enzyme and pathway databases

BioCyciNSP196162:GH4V-2145-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
Gene namesi
Ordered Locus Names:Noca_2150
OrganismiNocardioides sp. (strain ATCC BAA-499 / JS614)
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesNocardioidaceaeNocardioides
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003876991 – 314Acetaldehyde dehydrogenase 2Add BLAST314

Proteomic databases

PRIDEiA1SIM4

Interactioni

Protein-protein interaction databases

STRINGi196162.Noca_2150

Structurei

3D structure databases

ProteinModelPortaliA1SIM4
SMRiA1SIM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV Bacteria
COG4569 LUCA
HOGENOMiHOG000052149
KOiK04073
OMAiCLIGDAD
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

A1SIM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASTIPRQI AIIGSGNIGT DLMIKVLRLS KTLEVGAMVG IDPDSDGLAR
60 70 80 90 100
ANRLGVPTTS DGVDGLIRMP NFEAIDIVLD ATSARAHAAN YTALRRYRKR
110 120 130 140 150
MIDLTPAAVG PFVVPAVNMG ASLSADNVNM VTCGGQATIP IVAAISQVTP
160 170 180 190 200
VAYAEIVASI ASKSAGPGTR QNIDEFTETT AHAIEQVGGA RKGKAIIILN
210 220 230 240 250
PAEPPLIMRD TVLALIGPSD HDAVKGSIRA MVDAVAEYVP GYRLKQRIEI
260 270 280 290 300
QPLDGLPVGT LTSEPVTHKV SVFLEVEGAA HYLPAYAGNL DIMTSAALRV
310
AEAMAAQKLS GAVA
Length:314
Mass (Da):32,725
Last modified:February 6, 2007 - v1
Checksum:iF86FEF69218E7E0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000509 Genomic DNA Translation: ABL81659.1

Genome annotation databases

EnsemblBacteriaiABL81659; ABL81659; Noca_2150
KEGGinca:Noca_2150

Entry informationi

Entry nameiACDH2_NOCSJ
AccessioniPrimary (citable) accession number: A1SIM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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