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A1SI64 (A1SI64_NOCSJ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815
Ordered Locus Names:Noca_1989
OrganismNocardioides sp. (strain BAA-499 / JS614) [Complete proteome] [HAMAP]
Taxonomic identifier196162 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Nocardioidaceae › Nocardioides

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region260 – 2645ACP-binding By similarity HAMAP MF_01815

Sites

Active site1231 By similarity HAMAP MF_01815
Active site2591 By similarity HAMAP MF_01815
Active site2901 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
A1SI64 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: E6725871A235FCBC

FASTA33435,438
        10         20         30         40         50         60 
MATIIEQAEG ARHAGILGVG SYRPSRVIPN ADVVEAIDSS DEWIQQRSGI KQRRWATPEE 

        70         80         90        100        110        120 
TVQVMSVAAA RKALERASVD PRQIDCVIVA TVTHMIQTPA IATAIAYELG TDQAAAFDIS 

       130        140        150        160        170        180 
AACAGFCHGV AMAADMIRGG SAGHVLVIGV ERLSDLTDVG DRGTAFIFAD GAGAAVVGPT 

       190        200        210        220        230        240 
DAPGIGPVVW GSDGEQFELI RQREDWRDVV ASERPEMPHL VMQGNAVFRW ASYSMAKIGQ 

       250        260        270        280        290        300 
LALDRAGIGI DDLDVFVPHQ ANMRITDAMA RAMKLPERVK IARDIAEQGN TSAASIPLAL 

       310        320        330 
DRMIEEGEAR SGDKALLIAF GAGLAYAAQV VIVP

« Hide

References

[1]"Complete sequence of chromosome 1 of Nocardioides sp. JS614."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BAA-499 / JS614.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000509 Genomic DNA. Translation: ABL81499.1.
RefSeqYP_923186.1. NC_008699.1.

3D structure databases

ProteinModelPortalA1SI64.
SMRA1SI64. Positions 11-334.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1SI64.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4598304.
GenomeReviewsGene locus Noca_1989 in contig CP000509_GR.
KEGGnca:Noca_1989.
PATRIC22746019. VBINocSp122728_2254.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0332.
HOGENOMHBG649927.
OMASNCFIFA.
ProtClustDBCLSK2783510.

Enzyme and pathway databases

BioCycNSP35761:NOCA_1989-MONOMER.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA1SI64_NOCSJ
AccessionPrimary (citable) accession number: A1SI64
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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