A1SHX2 (A1SHX2_NOCSJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Error-prone DNA polymerase HAMAP MF_01902
EC=2.7.7.7 HAMAP MF_01902

Gene names

Name:	dnaE2 HAMAP MF_01902
Ordered Locus Names:	Noca_1897

Organism

Nocardioides sp. (strain BAA-499 / JS614) [Complete proteome] [HAMAP]

Taxonomic identifier

196162 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Nocardioidaceae › Nocardioides

Protein attributes

Sequence length	1145 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity. HAMAP MF_01902
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902 SAAS SAAS004013
Subcellular location	Cytoplasm By similarity HAMAP MF_01902 SAAS SAAS004013.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily. HAMAP MF_01902

Ontologies

Keywords
Biological process	DNA damage DNA repair HAMAP MF_01902 SAAS SAAS004013 DNA replication HAMAP MF_01902 SAAS SAAS004013
Cellular component	Cytoplasm HAMAP MF_01902 SAAS SAAS023073
Molecular function	DNA-directed DNA polymerase HAMAP MF_01902 SAAS SAAS004013 Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: HAMAP DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1SHX2 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: B8905C8A97F6DA3E	FASTA	1,145	125,198
	10 20 30 40 50 60 MGWSNPPISW GELEKRLSGR LSTPQDPEAP ISTRKRKRTR VDVARPAGPV TPYAELHCHS 70 80 90 100 110 120 SFSFLDGASG PDHLVLEALR LGLHGLAITD HDGFYGAPLF AETAQLHATN EQSLKTAYGA 130 140 150 160 170 180 ELSLGLTRPQ HGVADPEGGH LLVLARGVEG YHRLAGAITD AQLRGDEKGR PVYDLAELAE 190 200 210 220 230 240 RGRDHWLVLT GCRKGAVRRA LLEHGPVAAA AELDRLTALF GHDNVVVELI DHGYPTDSAH 250 260 270 280 290 300 NDLLAALAAD HGLRVVATNN VHHARPEQHR VADAMAAVRA RRSLAEMDGW LPASGMACLR 310 320 330 340 350 360 SGEEMVRRFA RYPGAVARSV ELADEIVFDL QKATPRLPKD GIPAGHTPST WLRELTERGF 370 380 390 400 410 420 AQRYAGGPLE TRARASVEHE LRIIAEKDFD GYFVIVHDIV AFARSRGILC QGRGSAASSA 430 440 450 460 470 480 VCYALGITAI DPVFYRLPFE RFISQHRDEE PDIDVDFDAG RREEVIQWVY ERYGRHNAAQ 490 500 510 520 530 540 VANVVGYRPK MAVRDAAKAL GHSPGQQDAW SKQVTSWTTV ATRDGGEHPA DLHVPAPVVA 550 560 570 580 590 600 LANGFLGAPR HLGIHSGGMV LTERPIGEVV PIERARMDKR TVLQWDKDGC EYMGLVKFDL 610 620 630 640 650 660 LGLGMLSALD HMMRIVEEHL GERWELSTIP KEEPAVYDLL CRADSVGVFQ VESRAQIGTL 670 680 690 700 710 720 PRLRPREFYD LAIEIALIRP GPIQGGAVHP YIRRATGREE VEYAHPSLVP VLERTKGVPL 730 740 750 760 770 780 FQEQLMDMAR VLGDCTRDEA DLLRRAMGSK RGIERIESIK DKLYEGMARK GLVGEEADAI 790 800 810 820 830 840 YLKILSFANF GFAESHALSF AKLVYASSWC KLHYPGAFLA ALLRAQPMGF YSPQSLVHDA 850 860 870 880 890 900 RRHGVEVLRP DLVRSAASAD LEPLAVADGP VGLPRCLVDH PERTDWVPGT PDPTPAHRRD 910 920 930 940 950 960 AAYAVRLGLD AVRGISAVVA ERIVAARAER PFADQADLSR RAGLDARQLE ALATAGAFDE 970 980 990 1000 1010 1020 AFPGGGLSRR QALWNAGWTE SEEHLEGIRA AGPAPMLPEM DEVEVTMADL WATGITPAQH 1030 1040 1050 1060 1070 1080 PFGHLRERLR AAGIKSVADT ASAEPGRRVH VAGLVTHRQR PGTAGGVTFL NLEDETGMLN 1090 1100 1110 1120 1130 1140 VICTVGVWRR HRATAAGAAG MVVRGILERQ DGVTNLVADR LAPIESVHPE AGQALRARHR SRDFQ

References

[1]

"Complete sequence of chromosome 1 of Nocardioides sp. JS614." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BAA-499 / JS614.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000509 Genomic DNA. Translation: ABL81407.1.
RefSeq	YP_923094.1. NC_008699.1.
3D structure databases
ProteinModelPortal	A1SHX2.
ModBase	Search...
Protein-protein interaction databases
STRING	A1SHX2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4596398.
GenomeReviews	Gene locus Noca_1897 in contig CP000509_GR.
KEGG	nca:Noca_1897.
PATRIC	22745837. VBINocSp122728_2168.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0587.
HOGENOM	HBG734490.
OMA	LATNRNG.
ProtClustDB	PRK05672.
Enzyme and pathway databases
BioCyc	NSP35761:NOCA_1897-MONOMER.
Family and domain databases
HAMAP	MF_01902. DNApol_error_prone. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR023073. DNA_pol_error_prone. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view]
KO	K14162.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A1SHX2_NOCSJ

Accession

Primary (citable) accession number: A1SHX2

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)