Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A1SHV9

- SYL_NOCSJ

UniProt

A1SHV9 - SYL_NOCSJ

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Nocardioides sp. (strain BAA-499 / JS614)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei617 – 6171ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNSP196162:GH4V-1912-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Noca_1884
OrganismiNocardioides sp. (strain BAA-499 / JS614)
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaeNocardioidaceaeNocardioides
ProteomesiUP000000640: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 848848Leucine--tRNA ligasePRO_0000334783Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196162.Noca_1884.

Structurei

3D structure databases

ProteinModelPortaliA1SHV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi69 – 7911"HIGH" regionAdd
BLAST
Motifi614 – 6185"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1SHV9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCPEQPHDTR AERDEMSEQT QQAAQPAETA AYDVRAIQDK WLPVWERLDP
60 70 80 90 100
FRADDSSPRE KKYALTMFPY PSGDLHMGHA EVTALHDVVA RYWWQRGYEV
110 120 130 140 150
LNPMGWDSFG LPAENAAIRN DEHPATYTYA NIETQYESFK RYAVSFDWSR
160 170 180 190 200
RLHTSDPEYY RWTQWLFLKF RERGLAYRKS SPVNWCPNDQ TVLANEQVVD
210 220 230 240 250
GRCERCGAEV TKRELTQWYF KITDYAQELL DRLDDLEPTW PARVVTAQRN
260 270 280 290 300
WIGRSEGAHV DFVVDGRDEP ITVYTTRPDT IFGTTFMVVA VDSPLAAELV
310 320 330 340 350
TDAQRPAFEA YREEIRKETE IERLSTDRPK TGVDLGVTAT NPVTGTQIPV
360 370 380 390 400
WATDYVLADY GTGAVMGVPG GDQRDWEFAT EMGLDIVRTT QTPEGFDGEA
410 420 430 440 450
YHGEGPAINS PAPGADAPLD INGLPVDEAK RATIEFLEQQ GTGAGAVNFR
460 470 480 490 500
LRDWLLSRQR YWGVPIPIIH CDACGEVAVP YDQLPLELPE LRGADLKPKG
510 520 530 540 550
VSPLAAAEEW VNVACPECGG AATRDSDTMD TFVDSSWYFL RYCSPDYTEG
560 570 580 590 600
PFDVEKAKAW MPADIYVGGV EHAVLHLLYA RFFTKVLRDM GMLEVDEPFA
610 620 630 640 650
AQLNQGIVIN QGKKMSKSLG NGVSLGDQLA EFGVDAVRVT LVFAGPPEDD
660 670 680 690 700
IDWADVSPAG ALRFLQRAWR LSGDVTSEAG TPAAGGDVAL RRVTARTVHD
710 720 730 740 750
AAELIESYRF NVMVARVMEL VNATRKAIDG APGPADPAVR EATETVAILL
760 770 780 790 800
SLVAPYVAEE MWERLGHEPT VARVGWPEVD PALLVEEQVT AVVQIQGKVR
810 820 830 840
ARLEVAPDIS EADLEQLAMA DPAVVRAIDG RPVRKVIVRA PKLVNVVV
Length:848
Mass (Da):94,337
Last modified:February 6, 2007 - v1
Checksum:i9FBB75346A8DB865
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000509 Genomic DNA. Translation: ABL81394.1.
RefSeqiWP_011755341.1. NC_008699.1.
YP_923081.1. NC_008699.1.

Genome annotation databases

EnsemblBacteriaiABL81394; ABL81394; Noca_1884.
GeneIDi4596385.
KEGGinca:Noca_1884.
PATRICi22745811. VBINocSp122728_2155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000509 Genomic DNA. Translation: ABL81394.1 .
RefSeqi WP_011755341.1. NC_008699.1.
YP_923081.1. NC_008699.1.

3D structure databases

ProteinModelPortali A1SHV9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196162.Noca_1884.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL81394 ; ABL81394 ; Noca_1884 .
GeneIDi 4596385.
KEGGi nca:Noca_1884.
PATRICi 22745811. VBINocSp122728_2155.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci NSP196162:GH4V-1912-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Nocardioides sp. JS614."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.
    , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BAA-499 / JS614.

Entry informationi

Entry nameiSYL_NOCSJ
AccessioniPrimary (citable) accession number: A1SHV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3