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A1SHV9

- SYL_NOCSJ

UniProt

A1SHV9 - SYL_NOCSJ

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Protein

Leucine--tRNA ligase

Gene
leuS, Noca_1884
Organism
Nocardioides sp. (strain BAA-499 / JS614)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei617 – 6171ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNSP196162:GH4V-1912-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Noca_1884
OrganismiNocardioides sp. (strain BAA-499 / JS614)
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaeNocardioidaceaeNocardioides
ProteomesiUP000000640: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 848848Leucine--tRNA ligaseUniRule annotationPRO_0000334783Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196162.Noca_1884.

Structurei

3D structure databases

ProteinModelPortaliA1SHV9.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi69 – 7911"HIGH" regionUniRule annotationAdd
BLAST
Motifi614 – 6185"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1SHV9-1 [UniParc]FASTAAdd to Basket

« Hide

MCPEQPHDTR AERDEMSEQT QQAAQPAETA AYDVRAIQDK WLPVWERLDP    50
FRADDSSPRE KKYALTMFPY PSGDLHMGHA EVTALHDVVA RYWWQRGYEV 100
LNPMGWDSFG LPAENAAIRN DEHPATYTYA NIETQYESFK RYAVSFDWSR 150
RLHTSDPEYY RWTQWLFLKF RERGLAYRKS SPVNWCPNDQ TVLANEQVVD 200
GRCERCGAEV TKRELTQWYF KITDYAQELL DRLDDLEPTW PARVVTAQRN 250
WIGRSEGAHV DFVVDGRDEP ITVYTTRPDT IFGTTFMVVA VDSPLAAELV 300
TDAQRPAFEA YREEIRKETE IERLSTDRPK TGVDLGVTAT NPVTGTQIPV 350
WATDYVLADY GTGAVMGVPG GDQRDWEFAT EMGLDIVRTT QTPEGFDGEA 400
YHGEGPAINS PAPGADAPLD INGLPVDEAK RATIEFLEQQ GTGAGAVNFR 450
LRDWLLSRQR YWGVPIPIIH CDACGEVAVP YDQLPLELPE LRGADLKPKG 500
VSPLAAAEEW VNVACPECGG AATRDSDTMD TFVDSSWYFL RYCSPDYTEG 550
PFDVEKAKAW MPADIYVGGV EHAVLHLLYA RFFTKVLRDM GMLEVDEPFA 600
AQLNQGIVIN QGKKMSKSLG NGVSLGDQLA EFGVDAVRVT LVFAGPPEDD 650
IDWADVSPAG ALRFLQRAWR LSGDVTSEAG TPAAGGDVAL RRVTARTVHD 700
AAELIESYRF NVMVARVMEL VNATRKAIDG APGPADPAVR EATETVAILL 750
SLVAPYVAEE MWERLGHEPT VARVGWPEVD PALLVEEQVT AVVQIQGKVR 800
ARLEVAPDIS EADLEQLAMA DPAVVRAIDG RPVRKVIVRA PKLVNVVV 848
Length:848
Mass (Da):94,337
Last modified:February 6, 2007 - v1
Checksum:i9FBB75346A8DB865
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000509 Genomic DNA. Translation: ABL81394.1.
RefSeqiWP_011755341.1. NC_008699.1.
YP_923081.1. NC_008699.1.

Genome annotation databases

EnsemblBacteriaiABL81394; ABL81394; Noca_1884.
GeneIDi4596385.
KEGGinca:Noca_1884.
PATRICi22745811. VBINocSp122728_2155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000509 Genomic DNA. Translation: ABL81394.1 .
RefSeqi WP_011755341.1. NC_008699.1.
YP_923081.1. NC_008699.1.

3D structure databases

ProteinModelPortali A1SHV9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196162.Noca_1884.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL81394 ; ABL81394 ; Noca_1884 .
GeneIDi 4596385.
KEGGi nca:Noca_1884.
PATRICi 22745811. VBINocSp122728_2155.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci NSP196162:GH4V-1912-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Nocardioides sp. JS614."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.
    , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BAA-499 / JS614.

Entry informationi

Entry nameiSYL_NOCSJ
AccessioniPrimary (citable) accession number: A1SHV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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