Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein translocase subunit SecA

Gene

secA

Organism
Nocardioides sp. (strain ATCC BAA-499 / JS614)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi911ZincUniRule annotation1
Metal bindingi913ZincUniRule annotation1
Metal bindingi922ZincUniRule annotation1
Metal bindingi923ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi101 – 108ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:Noca_1440
OrganismiNocardioides sp. (strain ATCC BAA-499 / JS614)
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesNocardioidaceaeNocardioides
Proteomesi
  • UP000000640 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003183991 – 937Protein translocase subunit SecAAdd BLAST937

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi196162.Noca_1440.

Structurei

3D structure databases

ProteinModelPortaliA1SGL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.
OrthoDBiPOG091H01RS.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1SGL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAILDKILR IGEGKILRQL EAIAQAVNAI EDDFVAMSDA ELQGMTAEFK
60 70 80 90 100
ERLANGESLD DIMPEAFATV REAARRVIGL RPFDVQVMGA GALHMGNIAE
110 120 130 140 150
MKTGEGKTLV AVLPSYLNAL SGKGVHIVTV NDYLAKFQSE MMGRVHHFLG
160 170 180 190 200
LTVGVILPEM RPDERRVAYN CDITYGTNNE LGFDYLRDNM AGSIEECVQR
210 220 230 240 250
GHNFAIVDEV DSILIDEART PLIISGPTQD EVHWYAEFAK VARNLVRDED
260 270 280 290 300
YEVDEKKRTI SVLEPGITKV EDHLGIENLY ESANTPLISF LHNSIKAKEL
310 320 330 340 350
FHNDKEYVVL NGEVLIVDEH TGRMLAGRRY NDGLHQAIEA KEDVQVREEY
360 370 380 390 400
QTLATVTLQN YFRLYDKLSG MTGTAMTEAS EFDKIYKLGV VPIPTNKPMA
410 420 430 440 450
RKDQADLVYR TEEAKYEAVV EDIAERHEKG QPILVGTVSV EKSEHLSAKL
460 470 480 490 500
KKRGIPHSVL NAKVHADEAK IVALAGHKGA VTVATNMAGR GTDIMLGGSV
510 520 530 540 550
EFLADAELRK RGLEPAGETA DEYQAEWPGT VERIKSQVAN EHDEVRALGG
560 570 580 590 600
LYVVGTERHE SRRIDNQLRG RSGRQGDPGE SRFYLSLQDE LMRLFKSDWV
610 620 630 640 650
DRVLQVLKIP DDVPIENKRV TSAIANAQGQ VESQNFESRK NVLKYDDVMD
660 670 680 690 700
RQRKVIYAER REVLEGKDLQ DQIRTFIDDT VTGYVTGATE EFAEEWDLEA
710 720 730 740 750
LWTALRQIYP VGVDYRVLEE EAGGRANMDR DELIAVLQKD AHEAYDRREA
760 770 780 790 800
EVGETVMREL ERRVVLSVLD RKWREHLYEM DYLREGIYLR AYSQRDPLVE
810 820 830 840 850
YQREGFEMFA AMMDGIKEES VGFLFNLEVQ VEIEEEDEEE EEVLEPMRQP
860 870 880 890 900
VPSFDQQGAM PQIRAKGLER PSQPTKLAYS APSEDGDAEV KGATVTNADD
910 920 930
EFAGVGRNDR CPCGSGKKFK QCHGRPGGPT GLTARVS
Length:937
Mass (Da):105,321
Last modified:February 6, 2007 - v1
Checksum:i7CC86260F35914A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000509 Genomic DNA. Translation: ABL80954.1.
RefSeqiWP_011754902.1. NC_008699.1.

Genome annotation databases

EnsemblBacteriaiABL80954; ABL80954; Noca_1440.
KEGGinca:Noca_1440.
PATRICi22744875. VBINocSp122728_1691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000509 Genomic DNA. Translation: ABL80954.1.
RefSeqiWP_011754902.1. NC_008699.1.

3D structure databases

ProteinModelPortaliA1SGL9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196162.Noca_1440.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL80954; ABL80954; Noca_1440.
KEGGinca:Noca_1440.
PATRICi22744875. VBINocSp122728_1691.

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.
OrthoDBiPOG091H01RS.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECA_NOCSJ
AccessioniPrimary (citable) accession number: A1SGL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.