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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Nocardioides sp. (strain ATCC BAA-499 / JS614)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi911ZincUniRule annotation1
Metal bindingi913ZincUniRule annotation1
Metal bindingi922ZincUniRule annotation1
Metal bindingi923ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi101 – 108ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:Noca_1440
OrganismiNocardioides sp. (strain ATCC BAA-499 / JS614)
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesNocardioidaceaeNocardioides
Proteomesi
  • UP000000640 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation
  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003183991 – 937Protein translocase subunit SecAAdd BLAST937

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi196162.Noca_1440

Structurei

3D structure databases

ProteinModelPortaliA1SGL9
SMRiA1SGL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6 Bacteria
COG0653 LUCA
HOGENOMiHOG000218168
KOiK03070
OMAiFEYDEVM
OrthoDBiPOG091H01RS

Family and domain databases

HAMAPiMF_01382 SecA, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR004027 SEC_C_motif
IPR000185 SecA
IPR020937 SecA_CS
IPR011115 SecA_DEAD
IPR014018 SecA_motor_DEAD
IPR011130 SecA_preprotein_X-link_dom
IPR011116 SecA_Wing/Scaffold
IPR036266 SecA_Wing/Scaffold_sf
IPR036670 SecA_X-link_sf
PANTHERiPTHR30612 PTHR30612, 2 hits
PfamiView protein in Pfam
PF02810 SEC-C, 1 hit
PF07517 SecA_DEAD, 1 hit
PF01043 SecA_PP_bind, 1 hit
PF07516 SecA_SW, 1 hit
PRINTSiPR00906 SECA
SMARTiView protein in SMART
SM00957 SecA_DEAD, 1 hit
SM00958 SecA_PP_bind, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
SSF81767 SSF81767, 1 hit
SSF81886 SSF81886, 2 hits
TIGRFAMsiTIGR00963 secA, 1 hit
PROSITEiView protein in PROSITE
PS01312 SECA, 1 hit
PS51196 SECA_MOTOR_DEAD, 1 hit

Sequencei

Sequence statusi: Complete.

A1SGL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAILDKILR IGEGKILRQL EAIAQAVNAI EDDFVAMSDA ELQGMTAEFK
60 70 80 90 100
ERLANGESLD DIMPEAFATV REAARRVIGL RPFDVQVMGA GALHMGNIAE
110 120 130 140 150
MKTGEGKTLV AVLPSYLNAL SGKGVHIVTV NDYLAKFQSE MMGRVHHFLG
160 170 180 190 200
LTVGVILPEM RPDERRVAYN CDITYGTNNE LGFDYLRDNM AGSIEECVQR
210 220 230 240 250
GHNFAIVDEV DSILIDEART PLIISGPTQD EVHWYAEFAK VARNLVRDED
260 270 280 290 300
YEVDEKKRTI SVLEPGITKV EDHLGIENLY ESANTPLISF LHNSIKAKEL
310 320 330 340 350
FHNDKEYVVL NGEVLIVDEH TGRMLAGRRY NDGLHQAIEA KEDVQVREEY
360 370 380 390 400
QTLATVTLQN YFRLYDKLSG MTGTAMTEAS EFDKIYKLGV VPIPTNKPMA
410 420 430 440 450
RKDQADLVYR TEEAKYEAVV EDIAERHEKG QPILVGTVSV EKSEHLSAKL
460 470 480 490 500
KKRGIPHSVL NAKVHADEAK IVALAGHKGA VTVATNMAGR GTDIMLGGSV
510 520 530 540 550
EFLADAELRK RGLEPAGETA DEYQAEWPGT VERIKSQVAN EHDEVRALGG
560 570 580 590 600
LYVVGTERHE SRRIDNQLRG RSGRQGDPGE SRFYLSLQDE LMRLFKSDWV
610 620 630 640 650
DRVLQVLKIP DDVPIENKRV TSAIANAQGQ VESQNFESRK NVLKYDDVMD
660 670 680 690 700
RQRKVIYAER REVLEGKDLQ DQIRTFIDDT VTGYVTGATE EFAEEWDLEA
710 720 730 740 750
LWTALRQIYP VGVDYRVLEE EAGGRANMDR DELIAVLQKD AHEAYDRREA
760 770 780 790 800
EVGETVMREL ERRVVLSVLD RKWREHLYEM DYLREGIYLR AYSQRDPLVE
810 820 830 840 850
YQREGFEMFA AMMDGIKEES VGFLFNLEVQ VEIEEEDEEE EEVLEPMRQP
860 870 880 890 900
VPSFDQQGAM PQIRAKGLER PSQPTKLAYS APSEDGDAEV KGATVTNADD
910 920 930
EFAGVGRNDR CPCGSGKKFK QCHGRPGGPT GLTARVS
Length:937
Mass (Da):105,321
Last modified:February 6, 2007 - v1
Checksum:i7CC86260F35914A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000509 Genomic DNA Translation: ABL80954.1
RefSeqiWP_011754902.1, NC_008699.1

Genome annotation databases

EnsemblBacteriaiABL80954; ABL80954; Noca_1440
KEGGinca:Noca_1440

Similar proteinsi

Entry informationi

Entry nameiSECA_NOCSJ
AccessioniPrimary (citable) accession number: A1SGL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: April 25, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health