Skip Header

Contribute Send feedback
Read comments (?) or add your own

A1SFS3 (A1SFS3_NOCSJ) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Uricase RuleBase RU004455 PIRNR PIRNR000241
EC=1.7.3.3 RuleBase RU004455 PIRNR PIRNR000241
Alternative name(s):
Urate oxidase PIRNR PIRNR000241
Gene names
Ordered Locus Names:Noca_1142 EMBL ABL80658.1
OrganismNocardioides sp. (strain BAA-499 / JS614) [Complete proteome] [HAMAP] EMBL ABL80658.1
Taxonomic identifier196162 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Nocardioidaceae › Nocardioides

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin By similarity. RuleBase RU004455 PIRNR PIRNR000241

Catalytic activity

Urate + O2 + H2O = 5-hydroxyisourate + H2O2. RuleBase RU004455 PIRNR PIRNR000241

Pathway

Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3. PIRNR PIRNR000241

Sequence similarities

Belongs to the uricase family. RuleBase RU004455 PIRNR PIRNR000241

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region223 – 2242Substrate binding By similarity PIRSR PIRSR000241-2

Sites

Active site1811Charge relay system By similarity PIRSR PIRSR000241-1
Active site2241Charge relay system By similarity PIRSR PIRSR000241-1
Binding site1811Substrate By similarity PIRSR PIRSR000241-2

Sequences

Sequence LengthMass (Da)Tools
A1SFS3 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: BB042F83E13CBA2B

FASTA28931,895
        10         20         30         40         50         60 
MATTDGSRIV LGANQYGKAE VRLLRVDRAS ERHTIEDLGI TTQLRGDFEA CHTHGDNSQV 

        70         80         90        100        110        120 
VPTDTQKNTI QAFARDGIGA PEHLLLRLAR HFTDGFAWVT GGRFDAESYA WERIGLPDGS 

       130        140        150        160        170        180 
GHDHSFVRTG RETRTATVEV DGDEVVVTAG LTDCTVLKST GSEFHGFSRD RYTTLPETTD 

       190        200        210        220        230        240 
RILATSIAAT WRYATTEVDF DARYAGVRDT LLATFATTHS LALQQTIFEM GKAVLERYDD 

       250        260        270        280 
VAEVSLSCPN KHHFLVDLEP FGLDNPGEVF FPADRPYGLI QATVRREGA

« Hide

References

[1]"Complete sequence of chromosome 1 of Nocardioides sp. JS614."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BAA-499 / JS614.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000509 Genomic DNA. Translation: ABL80658.1.
RefSeqYP_922345.1. NC_008699.1.

3D structure databases

ProteinModelPortalA1SFS3.
SMRA1SFS3. Positions 7-289.
ModBaseSearch...

Protein-protein interaction databases

STRING196162.Noca_1142.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL80658; ABL80658; Noca_1142.
GeneID4599317.
KEGGnca:Noca_1142.
PATRIC22744247. VBINocSp122728_1381.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3648.
HOGENOMHOG000250659.
KOK00365.
OMAHDHSFVR.
ProtClustDBCLSK881003.

Enzyme and pathway databases

BioCycNSP196162:GH4V-1197-MONOMER.
UniPathwayUPA00394; UER00650.

Family and domain databases

Gene3D3.10.270.10. 1 hit.
InterProIPR002042. Uricase.
[Graphical view]
PANTHERPTHR10395:SF1. PTHR10395:SF1. 1 hit.
PfamPF01014. Uricase. 2 hits.
[Graphical view]
PIRSFPIRSF000241. Urate_oxidase. 1 hit.
PRINTSPR00093. URICASE.
TIGRFAMsTIGR03383. urate_oxi. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA1SFS3_NOCSJ
AccessionPrimary (citable) accession number: A1SFS3
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: May 1, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info