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A1SFS3

- A1SFS3_NOCSJ

UniProt

A1SFS3 - A1SFS3_NOCSJ

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Protein
Uricase
Gene
Noca_1142
Organism
Nocardioides sp. (strain BAA-499 / JS614)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin By similarity.UniRule annotation

Catalytic activityi

Urate + O2 + H2O = 5-hydroxyisourate + H2O2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei181 – 1811Charge relay system By similarityUniRule annotation
Binding sitei181 – 1811Substrate By similarityUniRule annotation
Active sitei224 – 2241Charge relay system By similarityUniRule annotation

GO - Molecular functioni

  1. urate oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. purine nucleobase metabolic process Source: UniProtKB-KW
  2. urate catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Purine metabolismUniRule annotation

Enzyme and pathway databases

BioCyciNSP196162:GH4V-1161-MONOMER.
UniPathwayiUPA00394; UER00650.

Names & Taxonomyi

Protein namesi
Recommended name:
UricaseUniRule annotation (EC:1.7.3.3UniRule annotation)
Alternative name(s):
Urate oxidase
Gene namesi
Ordered Locus Names:Noca_1142Imported
OrganismiNocardioides sp. (strain BAA-499 / JS614)Imported
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaeNocardioidaceaeNocardioides
ProteomesiUP000000640: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi196162.Noca_1142.

Structurei

3D structure databases

ProteinModelPortaliA1SFS3.
SMRiA1SFS3. Positions 7-289.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni223 – 2242Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the uricase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3648.
HOGENOMiHOG000250659.
KOiK00365.
OMAiSDIIPTD.
OrthoDBiEOG6B6287.

Family and domain databases

InterProiIPR002042. Uricase.
[Graphical view]
PfamiPF01014. Uricase. 2 hits.
[Graphical view]
PIRSFiPIRSF000241. Urate_oxidase. 1 hit.
PRINTSiPR00093. URICASE.
TIGRFAMsiTIGR03383. urate_oxi. 1 hit.

Sequencei

Sequence statusi: Complete.

A1SFS3-1 [UniParc]FASTAAdd to Basket

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MATTDGSRIV LGANQYGKAE VRLLRVDRAS ERHTIEDLGI TTQLRGDFEA    50
CHTHGDNSQV VPTDTQKNTI QAFARDGIGA PEHLLLRLAR HFTDGFAWVT 100
GGRFDAESYA WERIGLPDGS GHDHSFVRTG RETRTATVEV DGDEVVVTAG 150
LTDCTVLKST GSEFHGFSRD RYTTLPETTD RILATSIAAT WRYATTEVDF 200
DARYAGVRDT LLATFATTHS LALQQTIFEM GKAVLERYDD VAEVSLSCPN 250
KHHFLVDLEP FGLDNPGEVF FPADRPYGLI QATVRREGA 289
Length:289
Mass (Da):31,895
Last modified:February 6, 2007 - v1
Checksum:iBB042F83E13CBA2B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000509 Genomic DNA. Translation: ABL80658.1.
RefSeqiWP_011754606.1. NC_008699.1.
YP_922345.1. NC_008699.1.

Genome annotation databases

EnsemblBacteriaiABL80658; ABL80658; Noca_1142.
GeneIDi4599317.
KEGGinca:Noca_1142.
PATRICi22744247. VBINocSp122728_1381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000509 Genomic DNA. Translation: ABL80658.1 .
RefSeqi WP_011754606.1. NC_008699.1.
YP_922345.1. NC_008699.1.

3D structure databases

ProteinModelPortali A1SFS3.
SMRi A1SFS3. Positions 7-289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196162.Noca_1142.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL80658 ; ABL80658 ; Noca_1142 .
GeneIDi 4599317.
KEGGi nca:Noca_1142.
PATRICi 22744247. VBINocSp122728_1381.

Phylogenomic databases

eggNOGi COG3648.
HOGENOMi HOG000250659.
KOi K00365.
OMAi SDIIPTD.
OrthoDBi EOG6B6287.

Enzyme and pathway databases

UniPathwayi UPA00394 ; UER00650 .
BioCyci NSP196162:GH4V-1161-MONOMER.

Family and domain databases

InterProi IPR002042. Uricase.
[Graphical view ]
Pfami PF01014. Uricase. 2 hits.
[Graphical view ]
PIRSFi PIRSF000241. Urate_oxidase. 1 hit.
PRINTSi PR00093. URICASE.
TIGRFAMsi TIGR03383. urate_oxi. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Nocardioides sp. JS614."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.
    , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BAA-499 / JS614.

Entry informationi

Entry nameiA1SFS3_NOCSJ
AccessioniPrimary (citable) accession number: A1SFS3
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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