Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uricase

Gene

Noca_1142

Organism
Nocardioides sp. (strain BAA-499 / JS614)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.UniRule annotation

Catalytic activityi

Urate + O2 + H2O = 5-hydroxyisourate + H2O2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei181 – 1811Charge relay systemUniRule annotation
Binding sitei181 – 1811SubstrateUniRule annotation
Active sitei224 – 2241Charge relay systemUniRule annotation

GO - Molecular functioni

  1. urate oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. purine nucleobase metabolic process Source: UniProtKB-KW
  2. urate catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Purine metabolismUniRule annotation

Enzyme and pathway databases

BioCyciNSP196162:GH4V-1161-MONOMER.
UniPathwayiUPA00394; UER00650.

Names & Taxonomyi

Protein namesi
Recommended name:
UricaseUniRule annotation (EC:1.7.3.3UniRule annotation)
Alternative name(s):
Urate oxidaseUniRule annotation
Gene namesi
Ordered Locus Names:Noca_1142Imported
OrganismiNocardioides sp. (strain BAA-499 / JS614)Imported
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaeNocardioidaceaeNocardioides
ProteomesiUP000000640: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi196162.Noca_1142.

Structurei

3D structure databases

ProteinModelPortaliA1SFS3.
SMRiA1SFS3. Positions 7-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni223 – 2242Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the uricase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3648.
HOGENOMiHOG000250659.
KOiK00365.
OMAiSDIIPTD.
OrthoDBiEOG6B6287.

Family and domain databases

InterProiIPR002042. Uricase.
[Graphical view]
PfamiPF01014. Uricase. 2 hits.
[Graphical view]
PIRSFiPIRSF000241. Urate_oxidase. 1 hit.
PRINTSiPR00093. URICASE.
TIGRFAMsiTIGR03383. urate_oxi. 1 hit.

Sequencei

Sequence statusi: Complete.

A1SFS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTDGSRIV LGANQYGKAE VRLLRVDRAS ERHTIEDLGI TTQLRGDFEA
60 70 80 90 100
CHTHGDNSQV VPTDTQKNTI QAFARDGIGA PEHLLLRLAR HFTDGFAWVT
110 120 130 140 150
GGRFDAESYA WERIGLPDGS GHDHSFVRTG RETRTATVEV DGDEVVVTAG
160 170 180 190 200
LTDCTVLKST GSEFHGFSRD RYTTLPETTD RILATSIAAT WRYATTEVDF
210 220 230 240 250
DARYAGVRDT LLATFATTHS LALQQTIFEM GKAVLERYDD VAEVSLSCPN
260 270 280
KHHFLVDLEP FGLDNPGEVF FPADRPYGLI QATVRREGA
Length:289
Mass (Da):31,895
Last modified:February 6, 2007 - v1
Checksum:iBB042F83E13CBA2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000509 Genomic DNA. Translation: ABL80658.1.
RefSeqiWP_011754606.1. NC_008699.1.
YP_922345.1. NC_008699.1.

Genome annotation databases

EnsemblBacteriaiABL80658; ABL80658; Noca_1142.
GeneIDi4599317.
KEGGinca:Noca_1142.
PATRICi22744247. VBINocSp122728_1381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000509 Genomic DNA. Translation: ABL80658.1.
RefSeqiWP_011754606.1. NC_008699.1.
YP_922345.1. NC_008699.1.

3D structure databases

ProteinModelPortaliA1SFS3.
SMRiA1SFS3. Positions 7-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196162.Noca_1142.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL80658; ABL80658; Noca_1142.
GeneIDi4599317.
KEGGinca:Noca_1142.
PATRICi22744247. VBINocSp122728_1381.

Phylogenomic databases

eggNOGiCOG3648.
HOGENOMiHOG000250659.
KOiK00365.
OMAiSDIIPTD.
OrthoDBiEOG6B6287.

Enzyme and pathway databases

UniPathwayiUPA00394; UER00650.
BioCyciNSP196162:GH4V-1161-MONOMER.

Family and domain databases

InterProiIPR002042. Uricase.
[Graphical view]
PfamiPF01014. Uricase. 2 hits.
[Graphical view]
PIRSFiPIRSF000241. Urate_oxidase. 1 hit.
PRINTSiPR00093. URICASE.
TIGRFAMsiTIGR03383. urate_oxi. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome 1 of Nocardioides sp. JS614."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.
    , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BAA-499 / JS614Imported.

Entry informationi

Entry nameiA1SFS3_NOCSJ
AccessioniPrimary (citable) accession number: A1SFS3
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: February 4, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.