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A1SFS3

- A1SFS3_NOCSJ

UniProt

A1SFS3 - A1SFS3_NOCSJ

Protein

Uricase

Gene

Noca_1142

Organism
Nocardioides sp. (strain BAA-499 / JS614)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.UniRule annotation

    Catalytic activityi

    Urate + O2 + H2O = 5-hydroxyisourate + H2O2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei181 – 1811Charge relay systemUniRule annotation
    Binding sitei181 – 1811SubstrateUniRule annotation
    Active sitei224 – 2241Charge relay systemUniRule annotation

    GO - Molecular functioni

    1. urate oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. purine nucleobase metabolic process Source: UniProtKB-KW
    2. urate catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Purine metabolismUniRule annotation

    Enzyme and pathway databases

    BioCyciNSP196162:GH4V-1161-MONOMER.
    UniPathwayiUPA00394; UER00650.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UricaseUniRule annotation (EC:1.7.3.3UniRule annotation)
    Alternative name(s):
    Urate oxidaseUniRule annotation
    Gene namesi
    Ordered Locus Names:Noca_1142Imported
    OrganismiNocardioides sp. (strain BAA-499 / JS614)Imported
    Taxonomic identifieri196162 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaeNocardioidaceaeNocardioides
    ProteomesiUP000000640: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi196162.Noca_1142.

    Structurei

    3D structure databases

    ProteinModelPortaliA1SFS3.
    SMRiA1SFS3. Positions 7-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni223 – 2242Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the uricase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3648.
    HOGENOMiHOG000250659.
    KOiK00365.
    OMAiSDIIPTD.
    OrthoDBiEOG6B6287.

    Family and domain databases

    InterProiIPR002042. Uricase.
    [Graphical view]
    PfamiPF01014. Uricase. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000241. Urate_oxidase. 1 hit.
    PRINTSiPR00093. URICASE.
    TIGRFAMsiTIGR03383. urate_oxi. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1SFS3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATTDGSRIV LGANQYGKAE VRLLRVDRAS ERHTIEDLGI TTQLRGDFEA    50
    CHTHGDNSQV VPTDTQKNTI QAFARDGIGA PEHLLLRLAR HFTDGFAWVT 100
    GGRFDAESYA WERIGLPDGS GHDHSFVRTG RETRTATVEV DGDEVVVTAG 150
    LTDCTVLKST GSEFHGFSRD RYTTLPETTD RILATSIAAT WRYATTEVDF 200
    DARYAGVRDT LLATFATTHS LALQQTIFEM GKAVLERYDD VAEVSLSCPN 250
    KHHFLVDLEP FGLDNPGEVF FPADRPYGLI QATVRREGA 289
    Length:289
    Mass (Da):31,895
    Last modified:February 6, 2007 - v1
    Checksum:iBB042F83E13CBA2B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000509 Genomic DNA. Translation: ABL80658.1.
    RefSeqiWP_011754606.1. NC_008699.1.
    YP_922345.1. NC_008699.1.

    Genome annotation databases

    EnsemblBacteriaiABL80658; ABL80658; Noca_1142.
    GeneIDi4599317.
    KEGGinca:Noca_1142.
    PATRICi22744247. VBINocSp122728_1381.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000509 Genomic DNA. Translation: ABL80658.1 .
    RefSeqi WP_011754606.1. NC_008699.1.
    YP_922345.1. NC_008699.1.

    3D structure databases

    ProteinModelPortali A1SFS3.
    SMRi A1SFS3. Positions 7-289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196162.Noca_1142.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL80658 ; ABL80658 ; Noca_1142 .
    GeneIDi 4599317.
    KEGGi nca:Noca_1142.
    PATRICi 22744247. VBINocSp122728_1381.

    Phylogenomic databases

    eggNOGi COG3648.
    HOGENOMi HOG000250659.
    KOi K00365.
    OMAi SDIIPTD.
    OrthoDBi EOG6B6287.

    Enzyme and pathway databases

    UniPathwayi UPA00394 ; UER00650 .
    BioCyci NSP196162:GH4V-1161-MONOMER.

    Family and domain databases

    InterProi IPR002042. Uricase.
    [Graphical view ]
    Pfami PF01014. Uricase. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000241. Urate_oxidase. 1 hit.
    PRINTSi PR00093. URICASE.
    TIGRFAMsi TIGR03383. urate_oxi. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Nocardioides sp. JS614."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.
      , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BAA-499 / JS614Imported.

    Entry informationi

    Entry nameiA1SFS3_NOCSJ
    AccessioniPrimary (citable) accession number: A1SFS3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3