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Protein

Uricase

Gene

Noca_1142

Organism
Nocardioides sp. (strain ATCC BAA-499 / JS614)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.UniRule annotation

Catalytic activityi

Urate + O2 + H2O = 5-hydroxyisourate + H2O2.UniRule annotation

Pathwayi: urate degradation

This protein is involved in step 1 of the subpathway that synthesizes (S)-allantoin from urate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uricase (Noca_1142)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway urate degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-allantoin from urate, the pathway urate degradation and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei18Charge relay systemUniRule annotation1
Active sitei63Charge relay systemUniRule annotation1
Active sitei252Charge relay systemUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processPurine metabolismUniRule annotation

Enzyme and pathway databases

BioCyciNSP196162:GH4V-1128-MONOMER
UniPathwayiUPA00394; UER00650

Names & Taxonomyi

Protein namesi
Recommended name:
UricaseUniRule annotation (EC:1.7.3.3UniRule annotation)
Alternative name(s):
Urate oxidaseUniRule annotation
Gene namesi
Ordered Locus Names:Noca_1142Imported
OrganismiNocardioides sp. (strain ATCC BAA-499 / JS614)Imported
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesNocardioidaceaeNocardioides
Proteomesi
  • UP000000640 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi196162.Noca_1142

Structurei

3D structure databases

ProteinModelPortaliA1SFS3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uricase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105FFA Bacteria
COG3648 LUCA
HOGENOMiHOG000250659
KOiK00365
OMAiKDRCFAT
OrthoDBiPOG091H08WJ

Family and domain databases

InterProiView protein in InterPro
IPR002042 Uricase
PfamiView protein in Pfam
PF01014 Uricase, 2 hits
PIRSFiPIRSF000241 Urate_oxidase, 1 hit
PRINTSiPR00093 URICASE
TIGRFAMsiTIGR03383 urate_oxi, 1 hit

Sequencei

Sequence statusi: Complete.

A1SFS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTDGSRIV LGANQYGKAE VRLLRVDRAS ERHTIEDLGI TTQLRGDFEA
60 70 80 90 100
CHTHGDNSQV VPTDTQKNTI QAFARDGIGA PEHLLLRLAR HFTDGFAWVT
110 120 130 140 150
GGRFDAESYA WERIGLPDGS GHDHSFVRTG RETRTATVEV DGDEVVVTAG
160 170 180 190 200
LTDCTVLKST GSEFHGFSRD RYTTLPETTD RILATSIAAT WRYATTEVDF
210 220 230 240 250
DARYAGVRDT LLATFATTHS LALQQTIFEM GKAVLERYDD VAEVSLSCPN
260 270 280
KHHFLVDLEP FGLDNPGEVF FPADRPYGLI QATVRREGA
Length:289
Mass (Da):31,895
Last modified:February 6, 2007 - v1
Checksum:iBB042F83E13CBA2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000509 Genomic DNA Translation: ABL80658.1
RefSeqiWP_011754606.1, NC_008699.1

Genome annotation databases

EnsemblBacteriaiABL80658; ABL80658; Noca_1142
KEGGinca:Noca_1142

Similar proteinsi

Entry informationi

Entry nameiA1SFS3_NOCSJ
AccessioniPrimary (citable) accession number: A1SFS3
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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