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Protein

Catalase-peroxidase

Gene

katG

Organism
Nocardioides sp. (strain ATCC BAA-499 / JS614)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei126Transition state stabilizerUniRule annotation1
Active sitei130Proton acceptorUniRule annotation1
Metal bindingi292Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei2691. NspCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Noca_0875
OrganismiNocardioides sp. (strain ATCC BAA-499 / JS614)
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesNocardioidaceaeNocardioides
Proteomesi
  • UP000000640 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003548521 – 760Catalase-peroxidaseAdd BLAST760

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki129 ↔ 251Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-277)UniRule annotation
Cross-linki251 ↔ 277Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-129)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi196162.Noca_0875.

Structurei

3D structure databases

ProteinModelPortaliA1SF13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1SF13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDSQDNRTP ESPQGVDRKA EGGCPVLHDG VTAQGSESEN PAIDSPTPRT
60 70 80 90 100
GGRPNSLKDW WPNHLDLSVL HAHSSKSSPL DPGFRYSEEF EKLDIEALRR
110 120 130 140 150
DIVEVLHTSQ DWWPADFGHY GGLFVRMAWH AAGTYRIHDG RGGAGQGAQR
160 170 180 190 200
FAPLNSWPDN ANLDKARRLL WPVKQKHGQK ISWADLIVFA GNVALEDMGF
210 220 230 240 250
TTFGFGFGRE DIWEPEEIYW GPEDTWLGDE RYSGDRELSN PLGAVQMGLI
260 270 280 290 300
YVNPEGPNGN PDPLASARDI RETFARMAMN DEETVALIAG GHTFGKTHGA
310 320 330 340 350
GDADLVGPEP EAAPLEAQGL GWHSSFGSGK GEDTITSGIE VTWTYHPTRW
360 370 380 390 400
DNEFFHILYA YEWELMKSAA GANQWRPKNG AGADMVPDAH DPSKRREPRM
410 420 430 440 450
LTSDLALRFD PEYAKISSRF KDHPEEFALA FAKAWYKLLH RDLGPIARYL
460 470 480 490 500
GPLVGETQIW QDPVPAVDHE LVSDDDVAAL KAKVLDSGLS VAELVSTAWA
510 520 530 540 550
SAASFRSTDK RGGANGARIR LEPQRSWAVN QPEQLAGVLD RLEGIQREFN
560 570 580 590 600
EAGGAKISLA DLIVLAGSAA VEKAAKDGGV DVTVPFRAGR TDASQEQTDV
610 620 630 640 650
DSFAVLEPRA DGFRNYLLEN EKAQPEVLLV ERAYLLGLTA PEMTVLVGGL
660 670 680 690 700
RALGNNVGGS GHGVLTDRPG VLTNDFFANL LAPGAQWKAS ESEANVYEIR
710 720 730 740 750
DLASGELRWT ATAVDLIFGS NSQLRSLAEV YASADAREKF VRDFVAAWVK
760
VMDADRFDLA
Length:760
Mass (Da):83,222
Last modified:February 6, 2007 - v1
Checksum:i6491CCF91EA4BCB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000509 Genomic DNA. Translation: ABL80398.1.
RefSeqiWP_011754347.1. NC_008699.1.

Genome annotation databases

EnsemblBacteriaiABL80398; ABL80398; Noca_0875.
KEGGinca:Noca_0875.
PATRICi22743745. VBINocSp122728_1132.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000509 Genomic DNA. Translation: ABL80398.1.
RefSeqiWP_011754347.1. NC_008699.1.

3D structure databases

ProteinModelPortaliA1SF13.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196162.Noca_0875.

Protein family/group databases

PeroxiBasei2691. NspCP01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL80398; ABL80398; Noca_0875.
KEGGinca:Noca_0875.
PATRICi22743745. VBINocSp122728_1132.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_NOCSJ
AccessioniPrimary (citable) accession number: A1SF13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: February 6, 2007
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.