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A1SE40

- NUON_NOCSJ

UniProt

A1SE40 - NUON_NOCSJ

Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Nocardioides sp. (strain BAA-499 / JS614)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    2. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro
    2. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciNSP196162:GH4V-544-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit NUniRule annotation
    NDH-1 subunit NUniRule annotation
    Gene namesi
    Name:nuoNUniRule annotation
    Ordered Locus Names:Noca_0533
    OrganismiNocardioides sp. (strain BAA-499 / JS614)
    Taxonomic identifieri196162 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaeNocardioidaceaeNocardioides
    ProteomesiUP000000640: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 533533NADH-quinone oxidoreductase subunit NPRO_0000391191Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi196162.Noca_0533.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalUniRule annotationAdd
    BLAST
    Transmembranei40 – 6021HelicalUniRule annotationAdd
    BLAST
    Transmembranei87 – 10721HelicalUniRule annotationAdd
    BLAST
    Transmembranei141 – 16121HelicalUniRule annotationAdd
    BLAST
    Transmembranei164 – 18421HelicalUniRule annotationAdd
    BLAST
    Transmembranei200 – 22021HelicalUniRule annotationAdd
    BLAST
    Transmembranei243 – 26321HelicalUniRule annotationAdd
    BLAST
    Transmembranei275 – 29521HelicalUniRule annotationAdd
    BLAST
    Transmembranei310 – 33021HelicalUniRule annotationAdd
    BLAST
    Transmembranei337 – 35721HelicalUniRule annotationAdd
    BLAST
    Transmembranei373 – 39321HelicalUniRule annotationAdd
    BLAST
    Transmembranei417 – 43721HelicalUniRule annotationAdd
    BLAST
    Transmembranei451 – 47121HelicalUniRule annotationAdd
    BLAST
    Transmembranei502 – 52221HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 2 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1007.
    HOGENOMiHOG000100794.
    KOiK00343.
    OMAiSIVQLAM.
    OrthoDBiEOG64JFNZ.

    Family and domain databases

    HAMAPiMF_00445. NDH1_NuoN_1.
    InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1SE40-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFIKPTIEY GDVWPLLVVF GVAAVGVLVE GFVPRAQRYL VQAALAIAGV    50
    VVALVGTILV ARDLDVLGDG AARGAIDVEG TIAVDGPALF IWGMLLVFAL 100
    GGALLFAERR LEGGVSAFAG QAAALPGTEA ERQASTRGLE HTEVYPLMMF 150
    ALGGMMLFAA ANDLLTLFVA LEVLSLPLYL LSGLARRRRL LSQEAALKYF 200
    MLGAFSSGFF LYGAALVYGF SGSMGFAEIN EAVRDDVGNQ TLLLIGIGML 250
    SVGLLFKVGA VPFHSWTPDV YQGAPTAVTA FMAAGTKIAA FGAMLRLFYV 300
    AFGSDRWSWQ PMLWIIAILT MLVGALIAIV QTDMKRMLAY SSVAHTGFLL 350
    TGVLGVQQAS ELADGEVTSL QAVLFYLVTY GFAVVGAFAV VTLVRDAGGE 400
    AGQFVRWRGI GRRSPLVAGV FAFFLLSMAG IPLTAGFVGK WAVFTVALAA 450
    GAWPVVIAAV LCSIIAVFFY VRVILLMFFE DDDVSAQGEV ASVTKPSVLT 500
    SATIFVGVAA TLVLGVVPGP VLDLAANAGQ FVR 533
    Length:533
    Mass (Da):56,131
    Last modified:February 6, 2007 - v1
    Checksum:i68DF5F7C1A0048E7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000509 Genomic DNA. Translation: ABL80075.1.
    RefSeqiWP_011754025.1. NC_008699.1.
    YP_921762.1. NC_008699.1.

    Genome annotation databases

    EnsemblBacteriaiABL80075; ABL80075; Noca_0533.
    GeneIDi4596200.
    KEGGinca:Noca_0533.
    PATRICi22743083. VBINocSp122728_0807.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000509 Genomic DNA. Translation: ABL80075.1 .
    RefSeqi WP_011754025.1. NC_008699.1.
    YP_921762.1. NC_008699.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196162.Noca_0533.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL80075 ; ABL80075 ; Noca_0533 .
    GeneIDi 4596200.
    KEGGi nca:Noca_0533.
    PATRICi 22743083. VBINocSp122728_0807.

    Phylogenomic databases

    eggNOGi COG1007.
    HOGENOMi HOG000100794.
    KOi K00343.
    OMAi SIVQLAM.
    OrthoDBi EOG64JFNZ.

    Enzyme and pathway databases

    BioCyci NSP196162:GH4V-544-MONOMER.

    Family and domain databases

    HAMAPi MF_00445. NDH1_NuoN_1.
    InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Nocardioides sp. JS614."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.
      , Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J., Richardson P.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BAA-499 / JS614.

    Entry informationi

    Entry nameiNUON_NOCSJ
    AccessioniPrimary (citable) accession number: A1SE40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 9, 2010
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3