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Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Nocardioides sp. (strain ATCC BAA-499 / JS614)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit NUniRule annotation
NDH-1 subunit NUniRule annotation
Gene namesi
Name:nuoNUniRule annotation
Ordered Locus Names:Noca_0533
OrganismiNocardioides sp. (strain ATCC BAA-499 / JS614)
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesNocardioidaceaeNocardioides
Proteomesi
  • UP000000640 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalUniRule annotationAdd BLAST21
Transmembranei40 – 60HelicalUniRule annotationAdd BLAST21
Transmembranei87 – 107HelicalUniRule annotationAdd BLAST21
Transmembranei141 – 161HelicalUniRule annotationAdd BLAST21
Transmembranei164 – 184HelicalUniRule annotationAdd BLAST21
Transmembranei200 – 220HelicalUniRule annotationAdd BLAST21
Transmembranei243 – 263HelicalUniRule annotationAdd BLAST21
Transmembranei275 – 295HelicalUniRule annotationAdd BLAST21
Transmembranei310 – 330HelicalUniRule annotationAdd BLAST21
Transmembranei337 – 357HelicalUniRule annotationAdd BLAST21
Transmembranei373 – 393HelicalUniRule annotationAdd BLAST21
Transmembranei417 – 437HelicalUniRule annotationAdd BLAST21
Transmembranei451 – 471HelicalUniRule annotationAdd BLAST21
Transmembranei502 – 522HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003911911 – 533NADH-quinone oxidoreductase subunit NAdd BLAST533

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi196162.Noca_0533.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CNR. Bacteria.
COG1007. LUCA.
HOGENOMiHOG000100794.
KOiK00343.
OMAiFIALEVM.
OrthoDBiPOG091H0B2L.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1. 1 hit.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

Sequencei

Sequence statusi: Complete.

A1SE40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFIKPTIEY GDVWPLLVVF GVAAVGVLVE GFVPRAQRYL VQAALAIAGV
60 70 80 90 100
VVALVGTILV ARDLDVLGDG AARGAIDVEG TIAVDGPALF IWGMLLVFAL
110 120 130 140 150
GGALLFAERR LEGGVSAFAG QAAALPGTEA ERQASTRGLE HTEVYPLMMF
160 170 180 190 200
ALGGMMLFAA ANDLLTLFVA LEVLSLPLYL LSGLARRRRL LSQEAALKYF
210 220 230 240 250
MLGAFSSGFF LYGAALVYGF SGSMGFAEIN EAVRDDVGNQ TLLLIGIGML
260 270 280 290 300
SVGLLFKVGA VPFHSWTPDV YQGAPTAVTA FMAAGTKIAA FGAMLRLFYV
310 320 330 340 350
AFGSDRWSWQ PMLWIIAILT MLVGALIAIV QTDMKRMLAY SSVAHTGFLL
360 370 380 390 400
TGVLGVQQAS ELADGEVTSL QAVLFYLVTY GFAVVGAFAV VTLVRDAGGE
410 420 430 440 450
AGQFVRWRGI GRRSPLVAGV FAFFLLSMAG IPLTAGFVGK WAVFTVALAA
460 470 480 490 500
GAWPVVIAAV LCSIIAVFFY VRVILLMFFE DDDVSAQGEV ASVTKPSVLT
510 520 530
SATIFVGVAA TLVLGVVPGP VLDLAANAGQ FVR
Length:533
Mass (Da):56,131
Last modified:February 6, 2007 - v1
Checksum:i68DF5F7C1A0048E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000509 Genomic DNA. Translation: ABL80075.1.
RefSeqiWP_011754025.1. NC_008699.1.

Genome annotation databases

EnsemblBacteriaiABL80075; ABL80075; Noca_0533.
KEGGinca:Noca_0533.
PATRICi22743083. VBINocSp122728_0807.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000509 Genomic DNA. Translation: ABL80075.1.
RefSeqiWP_011754025.1. NC_008699.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196162.Noca_0533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL80075; ABL80075; Noca_0533.
KEGGinca:Noca_0533.
PATRICi22743083. VBINocSp122728_0807.

Phylogenomic databases

eggNOGiENOG4105CNR. Bacteria.
COG1007. LUCA.
HOGENOMiHOG000100794.
KOiK00343.
OMAiFIALEVM.
OrthoDBiPOG091H0B2L.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1. 1 hit.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNUON_NOCSJ
AccessioniPrimary (citable) accession number: A1SE40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 6, 2007
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.