ID   A1SCG3_NOCSJ            Unreviewed;       516 AA.
AC   A1SCG3;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   SubName: Full=Metal-dependent phosphohydrolase, HD sub domain {ECO:0000313|EMBL:ABL79498.1};
GN   OrderedLocusNames=Noca_4918 {ECO:0000313|EMBL:ABL79498.1};
OS   Nocardioides sp. (strain ATCC BAA-499 / JS614).
OG   Plasmid pNOCA01 {ECO:0000313|EMBL:ABL79498.1,
OG   ECO:0000313|Proteomes:UP000000640}.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Nocardioides.
OX   NCBI_TaxID=196162 {ECO:0000313|EMBL:ABL79498.1, ECO:0000313|Proteomes:UP000000640};
RN   [1] {ECO:0000313|Proteomes:UP000000640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RC   PLASMID=pNOCA01 {ECO:0000313|Proteomes:UP000000640};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J.,
RA   Richardson P.;
RT   "Complete sequence of plasmid pNOCA01 of Nocardioides sp. JS614.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABL79498.1, ECO:0000313|Proteomes:UP000000640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RC   PLASMID=pNOCA01 {ECO:0000313|EMBL:ABL79498.1,
RC   ECO:0000313|Proteomes:UP000000640};
RX   PubMed=21551312; DOI=10.1128/JB.05109-11;
RA   Coleman N.V., Wilson N.L., Barry K., Brettin T.S., Bruce D.C., Copeland A.,
RA   Dalin E., Detter J.C., Del Rio T.G., Goodwin L.A., Hammon N.M., Han S.,
RA   Hauser L.J., Israni S., Kim E., Kyrpides N., Land M.L., Lapidus A.,
RA   Larimer F.W., Lucas S., Pitluck S., Richardson P., Schmutz J., Tapia R.,
RA   Thompson S., Tice H.N., Spain J.C., Gossett J.G., Mattes T.E.;
RT   "Genome Sequence of the ethene- and vinyl chloride-oxidizing actinomycete
RT   Nocardioides sp. strain JS614.";
RL   J. Bacteriol. 193:3399-3400(2011).
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DR   EMBL; CP000508; ABL79498.1; -; Genomic_DNA.
DR   AlphaFoldDB; A1SCG3; -.
DR   KEGG; nca:Noca_4918; -.
DR   eggNOG; COG2197; Bacteria.
DR   eggNOG; COG2206; Bacteria.
DR   HOGENOM; CLU_040286_1_0_11; -.
DR   OrthoDB; 9802066at2; -.
DR   Proteomes; UP000000640; Plasmid pNOCA01.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR037522; HD_GYP_dom.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR45228; CYCLIC DI-GMP PHOSPHODIESTERASE TM_0186-RELATED; 1.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF13487; HD_5; 2.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51832; HD_GYP; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Hydrolase {ECO:0000313|EMBL:ABL79498.1};
KW   Plasmid {ECO:0000313|EMBL:ABL79498.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000640}.
FT   DOMAIN          255..451
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
FT   DOMAIN          447..512
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50043"
SQ   SEQUENCE   516 AA;  55078 MW;  C8DADBF90FFC2D22 CRC64;
     MDPPADLRLS DVLAALSVAT DLGMGQHPEK AVRSCLLATG LGRALGLTEE ELRDVYFASL
     LRHLGCTATA SSEARWFGGD ELASRRAAER ADFGSRREML ALLVSTGRGS GLRRPLEVGR
     AVAGDLLHGR EIFASVCEAG ALLAGRLGLG EGVAVAIAQQ FERWDGTGGP GGLAGVEITL
     AARVSEVATQ ALLVHQEAGV DAVMSMLRDR SGSWFDPSVV EACARHGADL LRANDTVDPW
     QEVLEVEPAP VRRIRSGELD RVARCFADMV DLKSTYTLGH SSGTSELAEL AGRAIGLDDP
     AVGNLRRAAL LHDLGRVGVS SGIWDKPGAL TRSELEQVRL HPYHTERILA CSPVLAPLGR
     IAGLHHERLD GSGYHHGLAA AAIPIEARVL AAADTFQTLT QDRPHRAAHP PERAAERLAE
     EARAGRFDTD SVRAVVEAAG EQPAPVRGNW PSGLSDREVE VLRLVAKGLS NQEVAQTLVI
     SRRTAEHHVQ HVYAKIGTST RAAAALYAME HDLLRP
//