Skip Header

Contribute Send feedback
Read comments (?) or add your own

A1SAS8 (ILVC_SHEAM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:Sama_3282
OrganismShewanella amazonensis (strain ATCC BAA-1098 / SB2B) [Complete proteome] [HAMAP]
Taxonomic identifier326297 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 493493Ketol-acid reductoisomerase HAMAP MF_00435
PRO_1000190993

Sites

Active site1321 Potential

Sequences

Sequence LengthMass (Da)Tools
A1SAS8 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: B8BFD3FFA6ED4D81

FASTA49354,431
        10         20         30         40         50         60 
MANYFNSLNL RQQLAQLSQC RFMDRSEFEN GCDYIKGWNI VILGCGAQGL NQGLNMRDSG 

        70         80         90        100        110        120 
LNISYALRAE AIAEKRASWK KATDNGFTVG TFEELIPQAD LVLNLTPDKQ HSNVVNTVMP 

       130        140        150        160        170        180 
LMKQGATLSY SHGFNIVEEG MQVRPDITVI MVAPKCPGTE VREEYKRGFG VPTLIAVHPE 

       190        200        210        220        230        240 
NDPRGDGLEI AKAYASATGG DRAGVLHSSF IAEVKSDLMG EQTILCGMLQ TSAILGYEKM 

       250        260        270        280        290        300 
VADGVEPGYA AKLIQQGLET ITEALKQGGI TNMMDRLSNP AKIKAFDMAE ELKGILAPLF 

       310        320        330        340        350        360 
EKHMDDIISG EFSRTMMADW ANDDANLLRW RAETNETAFE NAPSSNEHID EQTYFDKGIF 

       370        380        390        400        410        420 
LVAMIKAGVE LAFDTMVDAG IIEESAYYES LHETPLIANT IARKRLYEMN VVISDTAEYG 

       430        440        450        460        470        480 
CYLFNHAAVP LLRDYVKSMS AEYLGGGLKD SSNAVDNVRL IEVNQAIRNT AVEFIGEELR 

       490 
GYMKDMKRIS AAQ

« Hide

References

[1]"Complete sequence of Shewanella amazonensis SB2B."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Fredrickson J., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1098 / SB2B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000507 Genomic DNA. Translation: ABM01485.1.
RefSeqYP_929154.1. NC_008700.1.

3D structure databases

ProteinModelPortalA1SAS8.
SMRA1SAS8. Positions 3-490.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1SAS8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4605529.
GenomeReviewsGene locus Sama_3282 in contig CP000507_GR.
KEGGsaz:Sama_3282.
NMPDRfig|326297.7.peg.3092.
PATRIC23455477. VBISheAma74963_3381.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0059.
HOGENOMHBG297205.
OMAEKHMDDI.
PhylomeDBA1SAS8.
ProtClustDBPRK05225.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
IPR014359. KetolA_reductoisomerase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PTHR21371:SF2. PTHR21371:SF2. 1 hit.
PfamPF01450. IlvC. 2 hits.
PF07991. IlvN. 1 hit.
[Graphical view]
PIRSFPIRSF000116. IlvC_gammaproteo. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 2 hits.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_SHEAM
AccessionPrimary (citable) accession number: A1SAS8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 6, 2007
Last modified: January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents